Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Eva Pipili-Synetos"'
Autor:
Christodoulos S. Flordellis, Eva Pipili-Synetos, Aglaia Athanassiadou, Evangelia Papadimitriou, Sosanna Kritikou, Michael E. Maragoudakis
Publikováno v:
British Journal of Pharmacology. 129:207-213
In order to elucidate further the role of nitric oxide (NO) as an endogenous antiangiogenic mediator, mRNA expression of inducible nitric oxide synthase (iNOS), enzyme activity and production of NO were determined in the chick chorioallantoic membran
Publikováno v:
British Journal of Pharmacology. 125:1252-1257
The involvement of platelets in neovascularization was investigated in the matrigel tube formation assay, an in vitro model of angiogenesis. Platelets promoted the formation of capillary-like structures (expressed as relative tube area) number- and t
Autor:
Eva Pipili-Synetos, Michael E. Maragoudakis, Dimitris Panagiotopoulos, Nancy Craniti, John Matsoukas, Eleni Sakkoula
Publikováno v:
Letters in Peptide Science. 3:227-232
We have recently shown that thrombin promotes angiogenesis by a mechanism independent of fibrin formation. In the present paper, we investigated the effect of the thrombin-receptor-activating tetradecapeptide (TRAP1–14, S42FLLRNPNDKYEPF55) for its
Publikováno v:
Microvascular Research. 50:215-222
A method providing a biochemical index for the evaluation of promoters or inhibitors of angiogenesis in the chick chorioallantoic membrane (CAM) is here described and validated. This method is based on the determination of collagenous protein synthes
Autor:
Athanasios A. Papageorgiou, Georgia Sotiropoulou, Theodore Fotsis, M.E. Maragoudakis, Eva Pipili-Synetos, George Karakiulakis, Eleni Sakkoula
Publikováno v:
British Journal of Pharmacology. 116:1829-1834
1. The effect of the nitric oxide (NO)-producing nitrovasodilators isosorbide mononitrate (ISMN) and isosorbide dinitrate (ISDN) were assessed on (a) the in vivo model of angiogenesis of the chick chorioallantoic membrane (CAM) and (b) on the growth
Publikováno v:
European Journal of Pharmacology. 258:151-154
The involvement of leukotrienes in angiogenesis was investigated in the in vivo chick chorioallantoic membrane system. In this system leukotrienes C4 and D4 promoted angiogenesis in a dose-dependent manner. Leukotriene B4 was ineffective. The potent
Autor:
Eva Pipili-Synetos, George C. Haralabopoulos, Platon Peristeris, Paraskevi Andriopoulou, Eleni Sakkoula, Michael E. Maragoudakis
Publikováno v:
British Journal of Pharmacology. 111:894-902
1. The involvement of nitric oxide (NO) in the regulation of angiogenesis was examined in the in vivo system of the chorioallantoic membrane (CAM) of the chick embryo and in the matrigel tube formation assay. 2. Sodium nitroprusside (SNP) (0.37-28 nm
Publikováno v:
Journal of Vascular Research. 30:202-208
Using the chick chorioallantoic membrane as a model system for the study of angiogenesis, we have shown that promoters of protein kinase C (PKC) such as 4-beta-phorbol-12-myristate-13-acetate (4-beta-PMA) and 1,2-dioctanoyl-sn-glycerol (DiC8) stimula
Publikováno v:
Journal of Autonomic Pharmacology. 11:343-351
1. The biological activity of a plasma-derived, clonidine displacing substance (CDS)-like material was tested on isolated rat aortic rings and compared to that of clonidine, an imidazoline with alpha 2-adrenoceptor agonist properties. 2. The CDS-like
Publikováno v:
British Journal of Pharmacology. 122:793-795
Interleukin-2 (IL-2), an immunoregulatory cytokine possessing antitumour activity, is an inducer of nitric oxide (NO) synthesis in mice and man. In this study, the possibility that IL-2 possesses antiangiogenic properties that account for its antitum