Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eva P. Cuevas"'
Autor:
Vanesa Nozal, Paula Fernández-Gómez, Alfonso García-Rubia, Loreto Martínez-González, Eva P. Cuevas, Eva Carro, Valle Palomo, Ana Martínez
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116626- (2024)
Multitarget ligands (MTLs) have emerged as an interesting alternative for addressing complex multifactorial pathologies such as neurodegenerative diseases. However, a common challenge associated with these compounds is often their high molecular weig
Externí odkaz:
https://doaj.org/article/3d33e86fd4984177be6742f62749d3db
Autor:
Eva P. Cuevas, Loreto Martinez-Gonzalez, Clara Gordillo, Carlota Tosat-Bitrián, Carmen Pérez de la Lastra, Amets Sáenz, Carmen Gil, Valle Palomo, Ángeles Martin-Requero, Ana Martinez
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106430- (2024)
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different post-translational modifications leading to a loss of function in
Externí odkaz:
https://doaj.org/article/b4e04e092b5c4a59a6337799371bb688
Autor:
Loreto Martinez-Gonzalez, Eva P. Cuevas, Carlota Tosat-Bitrián, Vanesa Nozal, Carmen Gil, Valle Palomo, Ángeles Martín-Requero, Ana Martinez
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase
Externí odkaz:
https://doaj.org/article/e4f7366995854e60ba83492f730a9c84
Autor:
Pilar Eraso, María J. Mazón, Victoria Jiménez, Patricia Pizarro-García, Eva P. Cuevas, Jara Majuelos-Melguizo, Jesús Morillo-Bernal, Amparo Cano, Francisco Portillo
Publikováno v:
Molecules, Vol 28, Iss 11, p 4433 (2023)
Lysyl oxidase-like 2 (LOXL2) was initially described as an extracellular enzyme involved in extracellular matrix remodeling. Nevertheless, numerous recent reports have implicated intracellular LOXL2 in a wide variety of processes that impact on gene
Externí odkaz:
https://doaj.org/article/7d4f76d2032740ee96f68f6682c11c5c
Autor:
Eva P. Cuevas, Alberto Rodríguez-Fernández, Valle Palomo, Ana Martínez, Ángeles Martín-Requero
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 385 (2022)
Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is currently no effective treatment. Despite advances in the molecular pathology of the characteristic histopathological markers of the disease (tau protein and β-amyloid), t
Externí odkaz:
https://doaj.org/article/2d5d8c9de43440c8a7fcedb4fb09d9e3
Autor:
Eva P. Cuevas, Gema Moreno-Bueno, Giacomo Canesin, Vanesa Santos, Francisco Portillo, Amparo Cano
Publikováno v:
Biology Open, Vol 3, Iss 2, Pp 129-137 (2014)
Summary Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues. However, many reports have suggested
Externí odkaz:
https://doaj.org/article/065b6d60758d4f52ac0e7320d4895829
Autor:
Ana Martinez, María del Valle Palomo Ruiz, Alberto Rodríguez Fernández, Eva P. Cuevas, Angeles Martin-Requero
Publikováno v:
Biomedicines; Volume 10; Issue 2; Pages: 385
19 p.-7 fig.-2 tab.
Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is currently no effective treatment. Despite advances in the molecular pathology of the characteristic histopathological markers of the disease (tau p
Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is currently no effective treatment. Despite advances in the molecular pathology of the characteristic histopathological markers of the disease (tau p
Autor:
Valle Palomo, Ana Martínez, Eva P. Cuevas, Concepción Pérez, Fernando Bartolomé, Vanesa Nozal, Carlota Tosat-Bitrián, Alfonso García-Rubia, David Ramírez, Eva Carro
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Angewandte Chemie (International Ed. in English)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Angewandte Chemie (International Ed. in English)
Digital.CSIC. Repositorio Institucional del CSIC
instname
12 p.-12 fig.-3 tab.-5 schem.
Multitarget directed ligands (MTDLs) are arising as promising tools to tackle complex diseases. The main goal of this work is to create powerful modulating agents for neurodegenerative disorders. To achieve this aim
Multitarget directed ligands (MTDLs) are arising as promising tools to tackle complex diseases. The main goal of this work is to create powerful modulating agents for neurodegenerative disorders. To achieve this aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad5525024ba101e7f5b2908bc701ce0
Autor:
Eva Cubillo, Antonio Diaz-Lopez, Eva P Cuevas, Gema Moreno-Bueno, Hector Peinado, Amalia Montes, Vanesa Santos, Francisco Portillo, Amparo Cano
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59948 (2013)
E12/E47 proteins (encoded by E2A gene) are members of the class I basic helix-loop-helix (bHLH) transcription factors (also known as E proteins). E47 has been described as repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT)
Externí odkaz:
https://doaj.org/article/f0422801c2d24484b3b81d84fd74859f
Autor:
Eva P. Cuevas, Vanesa Santos, Pilar Eraso, Francisco Portillo, Amparo Cano, Gema Moreno-Bueno, María J. Mazón
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the aggressiveness of cancer cells. EMT is triggered by activation of different transcription factors collectively known as EMT-TFs. Different cellular cues and cell signalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55ceb295a40ee0de2b8738b338255ef
https://hdl.handle.net/20.500.12530/32317
https://hdl.handle.net/20.500.12530/32317