Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy

Autor: Joanna Koziol, Paweł T. Matusik, Grzegorz Osmenda, Francesco D'Aiuto, Miroslaw Drozdz, Tomasz Mikolajczyk, Marta Czesnikiewicz-Guzik, Daniel Nowakowski, Eva Munoz-Aguilera, Piotr Pełka, Agata Schramm-Luc, Richard Nosalski, Maciej Tomaszewski, Mateusz Siedlinski, Tomasz J. Guzik, Mark J. Caulfield, Aneta Furtak, Evangelos Evangelou, Grzegorz Wilk, Tomasz Grodzicki

Publikováno v: Czesnikiewicz-Guzik, M, Osmenda, G, Siedlinski, M, Nosalski, R, Pelka, P, Nowakowski, D, Wilk, G, Mikolajczyk, T P, Schramm-Luc, A, Furtak, A, Matusik, P, Koziol, J, Drozdz, M, Munoz-Aguilera, E, Tomaszewski, M, Evangelou, E, Caulfield, M, Grodzicki, T, D'Aiuto, F & Guzik, T J 2019, ' Causal association between periodontitis and hypertension : Evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy ', European Heart Journal, vol. 40, no. 42, pp. 3459-3470 . https://doi.org/10.1093/eurheartj/ehz646
European Heart Journal

Aims Inflammation is an important driver of hypertension. Periodontitis is a chronic inflammatory disease, which could provide a mechanism for pro-hypertensive immune activation, but evidence of a causal relationship in humans is scarce. We aimed to

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http://hdl.handle.net/10044/1/79354