Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeA C) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

Autor: Hansruedi Glatt, Eva Muckel, Hanne Frederiksen, Walter Meinl, Ulrike Pabel, Henrik Lund Frandsen

Publikováno v: Carcinogenesis. 25:801-807

2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and some metabolites were investigated for mutagenicity in mammalian cell lines and bacterial strains engineered for the expression of human enzymes. MeAalphaC induced gene mutations (studied at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a833918fd33b5a75b4fe9c12cdc636a
https://doi.org/10.1093/carcin/bgh077

Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines

Autor: Fekadu Kassie, Volker Mersch Sundermann, Michael Kundi, R. Edenharder, Karl L. Platt, Maria Uhl, Eva Muckel, Firouz Darroudi, Siegfried Knasmüller, Evelyne F. Lhoste, C. Humbolt

Publikováno v: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2003, 523-524, pp.183-192. ⟨10.1016/S0027-5107(02)00334-2⟩

This article describes the development and use of assay models in vitro (genotoxicity assay with genetically engineered cells and human hepatoma (HepG2) cells) and in vivo (genotoxicity and short-term carcinogenicity assays with rodents) for the iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d102f371f220617195b5f8704fa2406
https://doi.org/10.1016/s0027-5107(02)00334-2

Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines

Autor: Henrik Lund Frandsen, Hansruedi Glatt, Eva Muckel

Publikováno v: Food and Chemical Toxicology. 40:1063-1068

A variety of carcinogenic heterocylic amines (HAs) are found in cooked food. They can be metabolised to reactive intermediates via N-hydroxylation catalysed by cytochrome P450 1A2, followed by conjugation of the resulting N-hydroxyl group by N-acetyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ac94b48096be3da91ffa17b9b978aa
https://doi.org/10.1016/s0278-6915(02)00032-7

A Protein Import Receptor of Chloroplasts Is Inserted into the Outer Envelope Membrane by a Novel Pathway

Autor: Jürgen Soll, Eva Muckel

Publikováno v: Journal of Biological Chemistry. 271:23846-23852

The outer envelope protein OEP86 functions as a receptor for precursor proteins in the chloroplastic import machinery. In contrast to most other organellar outer membrane proteins it is synthesized as a precursor polypeptide (preOEP86) in the cytosol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da207bc7880594e3020cebf1cbd4850d
https://doi.org/10.1074/jbc.271.39.23846

Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase

Autor: Volker M. Arlt, Bernd L. Sorg, Eva Muckel, David H. Phillips, Heinz H. Schmeiser, Ulrike Pabel, Hansruedi Glatt

Publikováno v: King's College London

3-Nitrobenzanthrone (3-NBA) an extremely potent mutagen and suspected human carcinogen identified in diesel exhaust and in airborne particulate matter was shown to form multiple DNA adducts in vitro and in vivo in rats. In order to investigate whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd5e420e7a61a27bbf3e6b1bb661ef6
https://pubmed.ncbi.nlm.nih.gov/12419844