Muscarinic acetylcholine receptors M2 are upregulated in the atrioventricular nodal tract in horses with a high burden of second-degree atrioventricular block

Autor: Sarah Dalgas Nissen, Arnela Saljic, Helena Carstensen, Thomas Hartig Braunstein, Eva Melis Hesselkilde, Sofie Troest Kjeldsen, Charlotte Hopster-Iversen, Alicia D’Souza, Thomas Jespersen, Rikke Buhl

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

BackgroundSecond-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone.AimTo assess whether AV block in horses is due to altered expression

Externí odkaz: https://doaj.org/article/f548dd78805443408379ce01d5ca2c8f

Inhibition of Small-Conductance Calcium-Activated Potassium Current (IK,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

Autor: Merle Friederike Fenner, Giulia Gatta, Stefan Sattler, Marion Kuiper, Eva Melis Hesselkilde, Ditte M. T. Adler, Morten Smerup, Ulrich Schotten, Ulrik Sørensen, Jonas Goldin Diness, Thomas Jespersen, Sander Verheule, Arne Van Hunnik, Rikke Buhl

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BackgroundSmall-conductance Ca2+-activated K+ (KCa2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the im

Externí odkaz: https://doaj.org/article/f83aac8393b7445e81accc751b356660

Arrhythmogenic mechanisms of acute obstructive respiratory events in a porcine model of drug-induced long QT

Autor: Dominik Linz, Stefan M. Sattler, Benedikt Linz, Eva Melis Hesselkilde, Jacob Tfelt-Hansen, Malthe Emil Høtbjerg Hansen, Thomas Jespersen, Arnela Saljic, Mette Flethøj, Klaus Wirth

Publikováno v: Heart Rhythm, 18(8), 1384-1391. Elsevier Science

BACKGROUND Obstructive sleep apnea is associated with increased risk of sudden cardiac death.OBJECTIVE The purpose of this study was to elucidate changes in ventricular repolarization and electromechanical interaction during obstructive respiratory e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db20535a47acbe68ac37c059fa8ed236
https://doi.org/10.1016/j.hrthm.2021.03.017

Implantable loop recorders can detect paroxysmal atrial fibrillation in Standardbred racehorses with intermittent poor performance

Autor: Eva Melis Hesselkilde, Prashanthan Sanders, Sofie Kraglund Poulsen, Rikke Buhl, Marie Louise Kjærgaard Winther, Charlotte Hopster-Iversen, Thomas Jespersen, Helena Carstensen, Sarah Dalgas Nissen

Publikováno v: Equine Veterinary Journal
Buhl, R, Nissen, S D, Winther, M L K, Poulsen, S K, Hopster-Iversen, C, Jespersen, T, Sanders, P, Carstensen, H & Hesselkilde, E M 2021, ' Implantable loop recorders can detect paroxysmal atrial fibrillation in Standardbred racehorses with intermittent poor performance ', Equine Veterinary Journal, vol. 53, no. 5, pp. 955-963 . https://doi.org/10.1111/evj.13372

Background: Limited information is available on paroxysmal atrial fibrillation (PAF) in the horse. Indeed, undiagnosed PAF could result in poor performance. Due to the intermittent occurrence, PAF is difficult to diagnose. However, implanting a small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d3f5370bd697d3a11039fa9798d5fa
https://doi.org/10.1111/evj.13372

Detection of atrial fibrillation with implantable loop recorders in horses

Autor: Jacob Tfelt-Hansen, Stefan M. Sattler, Eva Melis Hesselkilde, Rikke Buhl, Merle Frederike Fenner, Helena Carstensen, Thomas Jespersen

Publikováno v: Buhl, R, Hesselkilde, E M, Carstensen, H, Fenner, M F, Jespersen, T, Tfelt-Hansen, J & Sattler, S M 2021, ' Detection of atrial fibrillation with implantable loop recorders in horses ', Equine Veterinary Journal, vol. 53, no. 2, pp. 397-403 . https://doi.org/10.1111/evj.13301
Equine Veterinary Journal

BACKGROUND: Cardiac arrhythmias in horses are diagnosed by auscultation or electrocardiogram (ECG), which results in a low sensitivity for detecting arrhythmias that occur sporadically. Implantable loop recorders (ILRs) are small ECG devices placed s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19be41a84e43030e0a8476d51a2998d7
https://doi.org/10.1111/evj.13301