Výsledky vyhledávání - "Eva Mejia-Ramirez"

Akademický článek

Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice

Autor: Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian

Publikováno v: npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-17 (2022)

Abstract One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. He

Externí odkaz: https://doaj.org/article/a4bb8c5a146d41029eb29433f0022be5

Zobrazit plný text záznamu

Akademický článek

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

Publikováno v: Stem Cell Reports, Vol 13, Iss 3, Pp 515-529 (2019)

Summary: In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement during early huma

Externí odkaz: https://doaj.org/article/3c12a065cf724a05845be10b176cf5d3

Zobrazit plný text záznamu

Akademický článek

Understanding intrinsic hematopoietic stem cell aging

Autor: Eva Mejia-Ramirez, Maria Carolina Florian

Publikováno v: Haematologica, Vol 105, Iss 1 (2020)

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an organism. It is of extreme importance that these cells maintain self-renewal and differentiation potential over time in order to preserve homeostasis of the hemat

Externí odkaz: https://doaj.org/article/fd72735c15fb4ca5b8bcc0ab696ac7a4

Zobrazit plný text záznamu

Akademický článek

Critical Function of γH2A in S-Phase.

Autor: Eva Mejia-Ramirez, Oliver Limbo, Petra Langerak, Paul Russell

Publikováno v: PLoS Genetics, Vol 11, Iss 9, p e1005517 (2015)

Phosphorylation of histone H2AX by ATM and ATR establishes a chromatin recruitment platform for DNA damage response proteins. Phospho-H2AX (γH2AX) has been most intensively studied in the context of DNA double-strand breaks caused by exogenous clast

Externí odkaz: https://doaj.org/article/eb7e88a7149a48378439cfffe324d01b

Zobrazit plný text záznamu

Akademický článek

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Autor: Petra Langerak, Eva Mejia-Ramirez, Oliver Limbo, Paul Russell

Publikováno v: PLoS Genetics, Vol 7, Iss 9, p e1002271 (2011)

The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous recombination (HR) repair factor to double-strand breaks (DSBs). HR repair commences with the 5'-to-3' resection of DNA ends, gene

Externí odkaz: https://doaj.org/article/fc71716de1324abba27736f0887b6d72

Zobrazit plný text záznamu

Loss of epigenetic polarity is a hallmark of hematopoietic stem cell aging

Autor: M. Carolina Florian, Eva Mejia-Ramirez, Hartmut Geiger

Publikováno v: Human Molecular Genetics. 29:R248-R254

Changes of polarity in somatic stem cells upon aging or disease lead to a functional deterioration of stem cells and consequently loss of tissue homeostasis, likely due to changes in the mode (symmetry versus asymmetry) of stem cell divisions. Change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e4fc6e32e10f4929a5dc007ecc88bf
https://doi.org/10.1093/hmg/ddaa189

Zobrazit plný text záznamu