Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Eva Marie Y Moresco"'
Autor:
Yeshumenesh Zegeye, Bogale Aredo, Seher Yuksel, Dogan Can Kirman, Ashwani Kumar, Bo Chen, Emily Turpin, Sangita Shresta, Yu-Guang He, Laurent Gautron, Miao Tang, Xiaohong Li, Sophia M. DiCesare, John D. Hulleman, Chao Xing, Sara Ludwig, Eva Marie Y. Moresco, Bruce A. Beutler, Rafael L. Ufret-Vincenty
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Activated microglia have been implicated in the pathogenesis of age-related macular degeneration (AMD), diabetic retinopathy, and other neurodegenerative and neuroinflammatory disorders, but our understanding of the mechanisms behind their a
Externí odkaz:
https://doaj.org/article/9429c796dd824374af717a5bef932a51
Autor:
Xue Zhong, Nagesh Peddada, Jianhui Wang, James J. Moresco, Xiaowei Zhan, John M. Shelton, Jeffrey A. SoRelle, Katie Keller, Danielle Renee Lazaro, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Distinct pathways and molecules may support embryonic versus postnatal thymic epithelial cell (TEC) development and maintenance. Here, we identify a mechanism by which TEC numbers and function are maintained postnatally. A viable missense al
Externí odkaz:
https://doaj.org/article/9bb9af5e62a640e19549ec5330ca64ad
Autor:
Ran Song, William McAlpine, Aaron M. Fond, Evan Nair-Gill, Jin Huk Choi, Elisabeth E. L. Nyström, Liisa Arike, Sydney Field, Xiaohong Li, Jeffrey A. SoRelle, James J. Moresco, Eva Marie Y. Moresco, John R. Yates, Parastoo Azadi, Josephine Ni, George M. H. Birchenough, Bruce Beutler, Emre E. Turer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. Using a forward genetic screen, we have fou
Externí odkaz:
https://doaj.org/article/c2c5a71364e54a7780fc6c6274ed1f2e
Autor:
Ran Song, Aaron Fond, Xiaohong Li, Miao Tang, Xiaoming Zhan, Ruth Gordillo, Eva Marie Y. Moresco, Bruce Beutler, Emre E. Turer
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/4a61c0b13b4b4dca914b71c98d8e2e61
Autor:
Zhao Zhang, Yu Xun, Shunxing Rong, Lijuan Yan, Jeffrey A. SoRelle, Xiaohong Li, Miao Tang, Katie Keller, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Obesity is a major risk factor for fatty liver disease. Here, using a forward genetic screen, the authors identify the gene GM4951 as a GTPase involved in lipid oxidation and development of NAFLD in mice.
Externí odkaz:
https://doaj.org/article/0fb5045a02d548e7bf3ceeaa615047a3
Autor:
Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage o
Externí odkaz:
https://doaj.org/article/6f2f436288994d16853156c62b5e290b
Autor:
Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott, Jiexia Quan, Chun Hui Bu, Sara Hildebrand, Eva Marie Y. Moresco, Jean-François Bach, Bruce Beutler
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci t
Externí odkaz:
https://doaj.org/article/8f1693213fcf42edb01f31ae9b26c371
Autor:
Tao Wang, Chun Hui Bu, Sara Hildebrand, Gaoxiang Jia, Owen M. Siggs, Stephen Lyon, David Pratt, Lindsay Scott, Jamie Russell, Sara Ludwig, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Programs such as PolyPhen-2 predict the relative severity of damage by missense mutations. Here, Wang et al estimate probabilities that putative null or missense alleles would reduce protein function to cause detectable phenotype by analyzing data fr
Externí odkaz:
https://doaj.org/article/151023422b8a43e995162f958a228591
Autor:
Ming-Hsiu Yang, Jamie L. Russell, Yuto Mifune, Ying Wang, Hexin Shi, Eva Marie Y. Moresco, Daniel J. Siegwart, Bruce Beutler, Dale L. Boger
Publikováno v:
Journal of medicinal chemistry. 65(13)
The diprovocims, a new class of toll-like receptor (TLR) agonists, bear no similarity to prior TLR agonists, act through a well-defined mechanism (TLR1/TLR2 agonist), exhibit exquisite structure-activity relationships, and display in vivo adjuvant ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c917c6882a00860b95f425417e7f6cb
https://pubmed.ncbi.nlm.nih.gov/35767437
https://pubmed.ncbi.nlm.nih.gov/35767437
Autor:
William McAlpine, Kuan-wen Wang, Jin Huk Choi, Miguel San Miguel, Sarah Grace McAlpine, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Xiaoming Zhan, Mihwa Choi, Tao Wang, Chun Hui Bu, Anne R. Murray, Eva Marie Y. Moresco, Emre E. Turer, Bruce Beutler
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of
Externí odkaz:
https://doaj.org/article/e7d13b984c284195b19b267544941ddb