Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eva Maria Nichols"'
Autor:
Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O’Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty
Publikováno v:
Cells, Vol 12, Iss 23, p 2707 (2023)
The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the specific do
Externí odkaz:
https://doaj.org/article/aea08597c712489e973143c9958d8a70
Autor:
Gisela Jimenez-Duran, Joseph Kozole, Rachel Peltier-Heap, Eleanor R. Dickinson, Christopher R. Kwiatkowski, Francesca Zappacosta, Roland S. Annan, Nicholas W. Galwey, Eva-Maria Nichols, Louise K. Modis, Martha Triantafilou, Kathy Triantafilou, Lee M. Booty
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well as contributing
Externí odkaz:
https://doaj.org/article/18224861a8b0475c8ebbec8ed8c12015
Autor:
Eleonora Lekova, Wioleta M. Zelek, David Gower, Claus Spitzfaden, Isabelle H. Osuch, Elen John-Morris, Lasse Stach, Darren Gormley, Andrew Sanderson, Angela Bridges, Elizabeth R. Wear, Sebastien Petit-Frere, Michael N. Burden, Richard Priest, Trevor Wattam, Semra J. Kitchen, Maria Feeney, Susannah Davis, B. Paul Morgan, Eva-Maria Nichols
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Myasthenia Gravis (MG) is mediated by autoantibodies against acetylcholine receptors that cause loss of the receptors in the neuromuscular junction. Eculizumab, a C5-inhibitor, is the only approved treatment for MG that mechanistically addresses comp
Externí odkaz:
https://doaj.org/article/7143005e8ec646f3bc662008740e1e30
Autor:
Loveleena Bansal, Eva-Maria Nichols, Daniel P. Howsmon, Jessica Neisen, Christina M. Bessant, Fraser Cunningham, Sebastien Petit-Frere, Steve Ludbrook, Valeriu Damian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few
Externí odkaz:
https://doaj.org/article/af21613b5ce7409b84db7d116ea2d036
Autor:
Anna Gritsenko, Shi Yu, Fatima Martin-Sanchez, Ines Diaz-del-Olmo, Eva-Maria Nichols, Daniel M. Davis, David Brough, Gloria Lopez-Castejon
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/81cfd4f2726141ab98b471be2022bfc6
Autor:
Ines Diaz-del-Olmo, Jonathan Worboys, Fatima Martin-Sanchez, Anna Gritsenko, Ashley R. Ambrose, Gillian M. Tannahill, Eva-Maria Nichols, Gloria Lopez-Castejon, Daniel M. Davis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activatio
Externí odkaz:
https://doaj.org/article/3725774fdbf7494f95b7d579404763b0
Autor:
Anna Gritsenko, Shi Yu, Fatima Martin-Sanchez, Ines Diaz-del-Olmo, Eva-Maria Nichols, Daniel M. Davis, David Brough, Gloria Lopez-Castejon
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Interleukin (IL)-18 and IL-1β are potent pro-inflammatory cytokines that contribute to inflammatory conditions such as rheumatoid arthritis and Alzheimer’s disease. They are produced as inactive precursors that are activated by large macromolecula
Externí odkaz:
https://doaj.org/article/3f90c0557a3049ceb4f637e44217980f
Autor:
Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols
Publikováno v:
Antibodies, Vol 10, Iss 4, p 39 (2021)
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Externí odkaz:
https://doaj.org/article/9c08d3afb4f34afc913b99f6d81d4c48
Autor:
Suruchi Bakshi, Fraser Cunningham, Eva-Maria Nichols, Marta Biedzka-Sarek, Jessica Neisen, Sebastien Petit-Frere, Christina Bessant, Loveleena Bansal, Lambertus A. Peletier, Stefano Zamuner, Piet H. van der Graaf
Publikováno v:
Bull Math Biol
The complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central role in the function of the CS. The AP of complement system is implicated in several human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfcd27cb2ed42f24fe48ff941d978e3
https://doi.org/10.1007/s11538-021-00981-6
https://doi.org/10.1007/s11538-021-00981-6
Autor:
Jane E Clarkson, Nadia Tournier, Ryan P. Bingham, Maria Feeney, Semra Kitchen, Jo L Bramhall, Darren A. Gormley, Lasse Stach, Eva-Maria Nichols, Jane P. Hughes, Katherine A Welbeck, Claire L. Harris, Adam Taylor, Armin Sepp, Thil D. Batuwangala, Emily K H Dinley
Publikováno v:
Antibodies, Vol 10, Iss 39, p 39 (2021)
Antibodies
Volume 10
Issue 4
Antibodies
Volume 10
Issue 4
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b1db8d1109bbd8bf40b2ac3b17f78
https://www.mdpi.com/2073-4468/10/4/39
https://www.mdpi.com/2073-4468/10/4/39