Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eva Maria Martin, de la Nava"'
Autor:
Maria Angeles, Martinez-Grau, Isabel C Gonzalez, Valcarcel, Julie V, Early, Richard Klaus, Gessner, Candice Soares, de Melo, Eva Maria Martin, de la Nava, Aaron, Korkegian, Yulia, Ovechkina, Lindsay, Flint, Anisa, Gravelle, Jeff W, Cramer, Prashant V, Desai, Leslie J, Street, Joshua, Odingo, Thierry, Masquelin, Kelly, Chibale, Tanya, Parish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Highlights • We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis. • Improved compounds have sub-micromolar butyrate-specific activity. • Compounds are not cytot
Highlights • We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis. • Improved compounds have sub-micromolar butyrate-specific activity. • Compounds are not cytot
Autor:
Sandra L. Cockerham, Anthony G. Borel, Eva Maria Martin De La Nava, Daniel Ray Mayhugh, Sweetana Stephanie Ann, Nathan Bryan Mantlo, Youyan Zhang, Timothy M. Jones, Robert J. Schmidt, Thomas P. Beyer, Ellen A. Cannady, Ana Maria Escribano, Ana I. Mateo, Guoqing Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3671-3675
This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic propert
Autor:
Nathan Bryan Mantlo, Youyan Zhang, Eva Maria Martin De La Nava, Thomas P. Beyer, Gregory A. Stephenson, Saravanan Parthasarathy, Anthony G. Borel, Sandra L. Cockerham, Xiaodong Wang, Sweetana Stephanie Ann, Maria-Carmen Fernandez, Ana I. Mateo, Robert J. Schmidt, Ana Maria Escribano, Timothy M. Jones, Scott Alan Frank, Guoqing Cao, Ellen A. Cannady
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3056-3062
This Letter describes the discovery and SAR optimization of 1,5-tetrahydronaphthyridines, a new class of potent CETP inhibitors. The effort led to the identification of 21b and 21d with in vitro human plasma CETP inhibitory activity in the nanomolar
Autor:
Brian Stephen Muehl, Silke Voelkers, Gerd Ruehter, Kenneth Jeff Thrasher, Dirk Hankotius, Hans-Juergen Mest, Soenke Petersen, Martina Berg, Grit Riedel-Herold, Jeffrey Alan Dodge, Louis Nickolaus Jungheim, Britta Evers, Mark Joseph Tebbe, Ulrike Hary, Eva-Maria Martin de la Nava, Birgit Sommer, Michael Mohr
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6748-6762
A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the
Autor:
Carlos Perez Martinez, Jose Antonio Martinez Perez, David Andrew Coates, Concepcion Sanchez Martinez, Ana De Prado Gonzales, Miriam Filadelfa Del Prado Catalina, Alfonso De Dios Magana, Maria Dolores Martin Ortega Finger, Maria Cristina Garcia Paredes, John Monte Knobeloch, Ana Isabel Mateo Herranz, Eva Maria Martin De La Nava, Lawrence M. Gelbert
Publikováno v:
Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures ISBN: 9789048197033
The present invention provides a compound incorporating a group of formula (I) wherein: 1 of X, Y and Z is nitrogen and the other 2 are carbon; V is sulpur or carbon; R 3 is oxygen or fluorine; R 4 is an optionally present C 1-3 alkyl group optionall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd22c7013ff5765d7e90d15fc9859894
https://doi.org/10.1007/978-90-481-9704-0_17
https://doi.org/10.1007/978-90-481-9704-0_17