Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eva Maria Lopez-Roman"'
Autor:
María Jose Rebollo-Lopez, Joël Lelièvre, Daniel Alvarez-Gomez, Julia Castro-Pichel, Francisco Martínez-Jiménez, George Papadatos, Vinod Kumar, Gonzalo Colmenarejo, Grace Mugumbate, Mark Hurle, Vanessa Barroso, Rob J Young, María Martinez-Hoyos, Rubén González del Río, Robert H Bates, Eva Maria Lopez-Roman, Alfonso Mendoza-Losana, James R Brown, Emilio Alvarez-Ruiz, Marc A Marti-Renom, John P Overington, Nicholas Cammack, Lluís Ballell, David Barros-Aguire
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0142293 (2015)
As a follow up to the antimycobacterial screening exercise and the release of GSK´s first Tres Cantos Antimycobacterial Set (TCAMS-TB), this paper presents the results of a second antitubercular screening effort of two hundred and fifty thousand com
Externí odkaz:
https://doaj.org/article/8e46eddd23e54015ab4639bb3308df5d
Autor:
Eugenia Meiler, Eva Maria Lopez-Roman, Sophie Huss, Ruth Casanueva, Maciej K. Rogacki, Lluis Ballell, Laura Guijarro, Eleni Pitta, Koen Augustyns, Fraser Cunningham, Olga Balabon, David Barros Aguirre, Monica Cacho, Robert H. Bates, Angel Santos-Villarejo, Pieter Van der Veken
Publikováno v:
Journal of medicinal chemistry
In search of novel drugs against tuberculosis, we previously discovered and profiled a novel hydantoin-based family that demonstrated highly promising in vitro potency against M. tuberculosis. The compounds were found to be non-covalent inhibitors of
Autor:
Carine Sao Emani, Clement K. M. Tsui, Adama Bojang, Flavia Sorrentino, Yossef Av-Gay, María José Rebollo-López, Gagandeep Narula, Blanco Modesto J Remuinan, Eva Maria Lopez-Roman, Abraham L Moure, Beatriz Hernández Díaz, Esther Porras de Francisco, Patricia Casado Castro, Laura Guijarro López, Pedro Alfonso Torres-Gomez, Fátima Ortega, David Barros-Aguirre, Lluis Ballell, Isabel Camino
Publikováno v:
Journal of Medicinal Chemistry. 63:4732-4748
Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a thioalkylbenzoxazole hit. Biological profiling and mutant analysis revealed that this compound is a prodrug that is bioactivated by the mycobacter
Autor:
Paco de Dios-Anton, Chun-wa Chung, Elena Jimenez, Maria Santos Martinez-Martinez, Fraser Cunningham, Mythily Vimal, Ana Guardia, Raquel Fernandez-Menendez, Arancha Pérez, Jaime Escribano, Jorge Esquivias, Robert H. Bates, María José Rebollo-López, Verónica Sousa-Morcuende, Monica Cacho, Joaquín Rullas, Eva Maria Lopez-Roman, Cristina Rivero, Margaret Neu, Leticia Huertas Valentín
Publikováno v:
ACS Infectious Diseases. 6:1098-1109
In the course of optimizing a novel indazole sulfonamide series that inhibits β-ketoacyl-ACP synthase (KasA) of Mycobacterium tuberculosis, a mutagenic aniline metabolite was identified. Further lead optimization efforts were therefore dedicated to
Autor:
Lluis Ballell, Fraser Cunningham, Monica Cacho, Olga Balabon, Christophe M. L. Vande Velde, Delia Blanco-Ruano, Argyrides Argyrou, David Barros, Sophie Huss, Eleni Pitta, Pieter Van der Veken, Koen Augustyns, Robert H. Bates, Eva Maria Lopez-Roman, Maciej K. Rogacki
Publikováno v:
Journal of medicinal chemistry
Tuberculosis is the leading cause of death worldwide from infectious diseases. With the development of drug-resistant strains of Mycobacterium tuberculosis, there is an acute need for new medicines with novel modes of action. Herein, we report the di
Autor:
Robert H. Bates, Deborah T. Hung, Eva Maria Lopez-Roman, Brian K. Hubbard, Katie K. Lee, David Barros-Aguirre, Laura Guijarro-López, Stewart L. Fisher, Zuozhong Peng, James Gomez, Michael H Serrano-Wu, Yunxing Yin, Raquel Fernandez-Menendez, Chao Fang, Raymond M. Nietupski
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Previous work established a coumarin scaffold as a starting point for inhibition of Mycobacterium tuberculosis (Mtb) FadD32 enzymatic activity. After further profiling of the coumarin inhibitor 4 revealed chemical instability, we discovered that a qu
Autor:
Eamonn Gormley, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Eva Maria Lopez-Roman, Nacho Aguilo, Ana Maria Toledo, Carlos Martin, Iñigo Angulo-Barturen
Publikováno v:
Clinical and Vaccine Immunology
Clinical and Vaccine Immunology; Vol 21
Clinical and Vaccine Immunology; Vol 21
Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides
Autor:
Pieter Van der Veken, Sophie Huss, Eleni Pitta, Robert H. Bates, Fraser Cunningham, Olga Balabon, Eva Maria Lopez-Roman, Maciej K. Rogacki, Lluis Ballell, Koen Augustyns, Jurgen Joossens
Publikováno v:
Journal of medicinal chemistry
In this study, a new series of more than 60 quinoline derivatives has been synthesized and evaluated against Mycobacterium tuberculosis (H37Rv). Apart from the SAR exploration around the initial hits, the optimization process focused on the improveme
Autor:
Roman Šink, Joaquin Rullas-Triconado, Lluís Ballell-Pages, Eva Maria Lopez-Roman, Robert J. Young, Lourdes Encinas, David Barros, Raquel Fernandez-Menendez, Samo Turk, Matej Živec, Stane Pajk, Izidor Sosič, Stanislav Gobec, Iñigo Angulo-Barturen, Daniel Alvarez-Gomez, Carolina Gonzales-Cortez
Publikováno v:
Journal of medicinal chemistry. 58(2)
Mycobacterial enoyl acyl carrier protein reductase (InhA) is a clinically validated target for the treatment of tuberculosis infections, a disease that still causes the death of at least a million people annually. A known class of potent, direct, and
Autor:
Beatriz C. Jiménez, Eva Maria Lopez-Roman, Alfonso Mendoza, Rogelio López-Vélez, Helena Huerga, Miriam Navarro
Publikováno v:
Journal of travel medicine. 13(6)
There is limited data regarding the efficacy of prophylaxis with atovaquone/proguanil (A/P) against non-falciparum malaria in travelers. Two cases, one Plasmodium vivax infection and another Plasmodium ovale infection, in travelers despite A/P prophy