Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Eva Maria Herold"'
Autor:
Lisa Hospach, Albert Jesuran Paul, Nina Rettich, Hans Kiefer, Bettina Halder, Eva Maria Herold, Martina Röhm, Fabian Bickel, René Handrick, Friedemann Hesse
Publikováno v:
Analytical and bioanalytical chemistry. 409(17)
Aggregation of therapeutic proteins is a major concern as aggregates lower the yield and can impact the efficacy of the drug as well as the patient's safety. It can occur in all production stages; thus, it is essential to perform a detailed analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b627a88525ded3a6e200a02557129a
https://pubmed.ncbi.nlm.nih.gov/28447132
https://pubmed.ncbi.nlm.nih.gov/28447132
Autor:
Benedikt Weber, Stephan Kremser, Carolin Berner, Eva Maria Herold, Johannes Buchner, Jonathan Eras, Christine John, Sabrina Deubler, Martin Zacharias
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports, 7
The antibody Fv module which binds antigen consists of the variable domains VL and VH. These exhibit a conserved ß-sheet structure and comprise highly variable loops (CDRs). Little is known about the contributions of the framework residues and CDRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba027ef4f42945f3e9e2760be0de0ee3
Autor:
Sebastian Grundmann, Thomas Helbing, Cam Patterson, Eva Maria Herold, Alexandra Hornstein, Jennifer Heinke, Christoph Bode, Stefanie Wintrich, Martin Moser
Publikováno v:
The Journal of Pathology. 231:105-116
Epithelial injury is a central finding in pulmonary disease and is accompanied by disruption of epithelial barrier function, leading to pulmonary oedema and inflammation. Injured epithelial cells lose their properties and gain mesenchymal characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cfbc743e247d5143c37c292857295bb
https://doi.org/10.1002/path.4215
https://doi.org/10.1002/path.4215
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
We investigated the influence of pH and sodium chloride concentration on aggregation kinetics of a monoclonal antibody. Aggregation was induced by sodium chloride addition at low pH. Protein conformation before and after salt addition was determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898f27a0246d5c75ff047a0aff0d773e
https://pubmed.ncbi.nlm.nih.gov/27449627
https://pubmed.ncbi.nlm.nih.gov/27449627
Autor:
Matthias J. Feige, Alexander Bepperling, Klaus Heger, Eva Maria Herold, Emma Rhiannon Simpson, Johannes Buchner
Publikováno v:
Journal of Molecular Biology. 399:719-730
Intact antibodies and antigen binding fragments (Fab) have been previously shown to form an alternatively folded state (AFS) at low pH. This state consists primarily of secondary structure interactions, with reduced tertiary structure content. The AF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7530bfa9a992c42d39d893c3c0061201
https://doi.org/10.1016/j.jmb.2010.04.032
https://doi.org/10.1016/j.jmb.2010.04.032
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins
Autor:
Janosch Hennig, Jirka Peschek, Julia Behnke, Michael Groll, Michael Sattler, Martin F. Flajnik, Moritz Marcinowski, Matthias J. Feige, Johannes Buchner, David Ausländer, Melissa Ann Gräwert, Caitlin D. Castro, Eva Maria Herold, Linda M. Hendershot
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 111, 8155-8160 (2014)
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely on antibodies as part of their adaptive immune system. They produce the immunoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3c107016bdd45b92bd0c63f97685d0
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=31294
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=31294
Autor:
Thomas, Helbing, Eva-Maria, Herold, Alexandra, Hornstein, Stefanie, Wintrich, Jennifer, Heinke, Sebastian, Grundmann, Cam, Patterson, Christoph, Bode, Martin, Moser
Publikováno v:
The Journal of pathology. 231(1)
Epithelial injury is a central finding in pulmonary disease and is accompanied by disruption of epithelial barrier function, leading to pulmonary oedema and inflammation. Injured epithelial cells lose their properties and gain mesenchymal characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::950767c849933227c4d9a90c132a5c0e
https://pubmed.ncbi.nlm.nih.gov/23716395
https://pubmed.ncbi.nlm.nih.gov/23716395
Publikováno v:
Journal of molecular biology. 392(5)
Antibodies are modular proteins consisting of domains that exhibit a beta-sandwich structure, the so-called immunoglobulin fold. Despite structural similarity, differences in folding and stability exist between different domains. In particular, the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe669e99907f1e3571e2b208a470cda
https://pubmed.ncbi.nlm.nih.gov/19647749
https://pubmed.ncbi.nlm.nih.gov/19647749