Výsledky vyhledávání - "Eva Maria Collnot"

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease

Autor: Biana Godin, Fransisca Leonard, Claus-Michael Lehr, Srimeenakshi Srinivasan, Mauro Ferrari, Eva Maria Collnot, Xuewu Liu

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 151:61-72

Inflammatory bowel disease (IBD) affects a confined area of the intestine and, therefore, administration of drugs via oral route is preferable. However, obstacles such as changes in the pH along gastrointestinal tract (GIT), enzymatic activity, and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac996227e5a7cb7ddf32ef25a650be3
https://doi.org/10.1016/j.ejpb.2020.03.020

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Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Autor: David E. Lefebvre, Rekha Mehta, Hans Bouwmeester, Genevieve S. Bondy, Koen Venema, Vicki Stone, Jayadev Raju, Eva Maria Collnot, R. Paul Singh, Luis G. Valerio, Lourdes Gombau, Amy J. Clippinger

Publikováno v: Nanotoxicology 9 (2015) 4
Nanotoxicology, 9(4), 523-542. Informa Healthcare
Nanotoxicology, 9(4), 523-542

Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refineme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38b94a970c376ad086a4a35beee4ed6
https://doi.org/10.3109/17435390.2014.948091

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Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases

Autor: Eva-Maria Collnot, Benno Weigmann, Hussain Ali, M.F. Neurath, Claus-Michael Lehr, Maike Windbergs

Publikováno v: Journal of Controlled Release. 183:167-177

The purpose of this study was to investigate the therapeutic potential of budesonide loaded nanocarriers for the treatment of inflammatory bowel disease (IBD). First, budesonide was encapsulated in poly(lactic-co-glycolic) acid (PLGA) nanoparticles b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d604c060a29cb01fea4943339fa5c54
https://doi.org/10.1016/j.jconrel.2014.03.039

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PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment

Publikováno v: Regulatory Toxicology and Pharmacology; Vol 68
Regulatory Toxicology and Pharmacology

Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and compared with in vitro actual cell exposure associated to effects (in vitro-in vivo comparison). D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6189b3581a49ac10fbaccd39637bd503
https://doi.org/10.1016/j.yrtph.2013.11.008

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Dual flow bioreactor with ultrathin microporous TEER sensing membrane for evaluation of nanoparticle toxicity

Autor: Martha Liley, Nadia Ucciferri, Claus-Michael Lehr, Tommaso Sbrana, Mèlanie Favrè, Sher Ahmed, Eva Maria Collnot, Arti Ahluwalia

Permeability studies across biological barriers are of primary importance in drug delivery as well as in toxicology when investigating the absorption and translocation of a substance. The study of nanomaterial interaction with epithelial barriers is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfb9e70cca816c0e03eab30729c233c
http://hdl.handle.net/11568/776739

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Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa

Autor: Claus-Michael Lehr, Eva-Maria Collnot, Hussain Ali

Publikováno v: Journal of Controlled Release. 161:235-246

Conventional treatment of inflammatory bowel disease (IBD) is based on the daily administration of high doses of immune-suppressant or anti-inflammatory drugs, often complicated by serious adverse effects. Thus, a carrier system that delivers the dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d009425cb98f07639f6568a78e9b56c
https://doi.org/10.1016/j.jconrel.2012.01.028

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Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

Autor: Bart J Crielaard, Eva Maria Collnot, Claus-Michael Lehr, Gert Storm, Hussain Ali, Twan Lammers, Fransisca Leonard

Publikováno v: Scopus-Elsevier

Drug formulation screenings for treatment of inflammatory bowel disease (IBD) are mostly conducted in chemically induced rodent models that represent acute injury-caused inflammation instead of a chronic condition. To accurately screen drug formulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a7357613245ed543fde24f83aeec49
https://doi.org/10.14573/altex.2012.3.275

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Dexamethasone-loaded nanoparticle-coated microparticles: Correlation between in vitro drug release and drug transport across Caco-2 cell monolayers

Autor: Marcia Russman Gallas, Ulrich F. Schaefer, Eva-Maria Collnot, Claus-Michael Lehr, Ruy Carlos Ruver Beck, Cristiane Rodrigues Drago Hoffmeister, Adriana Raffin Pohlmann, S.S. Guterres

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 67:18-30

This work reports the preparation of dexamethasone in nanoparticle-coated microparticles and the study of the influence of such microencapsulation on drug absorption across Caco-2 cell monolayers. Nanoparticle-coated microparticles were prepared by s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9ac1d357968e1dad35946605b4aa35
https://doi.org/10.1016/j.ejpb.2007.01.007

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Mechanism of Inhibition of P-Glycoprotein Mediated Efflux by Vitamin E TPGS: Influence on ATPase Activity and Membrane Fluidity

Autor: Michael F. Wempe, Eva-Maria Collnot, Kevin J. Edgar, Ulrich F. Schaefer, Jürgen Hüttermann, John A. Hyatt, Claus-Michael Lehr, Reinhard Kappl, Christiane Baldes

Publikováno v: Molecular Pharmaceutics. 4:465-474

Efflux pump (e.g., P-gp, MRP1, and BCRP) inhibition has been recognized as a strategy to overcome multi-drug resistance and improve drug bioavailability. Besides small-molecule inhibitors, surfactants such as Tween 80, Cremophor EL, several Pluronics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18bebb6a883e7a2ec29796cd39690ce
https://doi.org/10.1021/mp060121r

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Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa--Pharmaceutical Characterization and Fluorescence Imaging

Autor: Benno Weigmann, Claus-Michael Lehr, Maike Windbergs, Eva-Maria Collnot, Hussain Ali, Saeed Ahmad Khan

Publikováno v: Pharmaceutical research. 33(5)

The purpose of this study was to evaluate the specifically targeted efficiency of budesonide loaded PLGA nanoparticles for the treatment of inflammatory bowel disease (IBD). The nanoparticles were prepared by an oil/water (O/W) emulsion evaporation t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007dda6c0914352b3e8548b25266e79c
https://pubmed.ncbi.nlm.nih.gov/26718953

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