Evaluation of the Effect of β-Wrapin AS69 in a Mouse Model Based on Alpha-Synuclein Overexpression

Autor: Lennart Höfs, David Geißler-Lösch, Kristof M. Wunderlich, Eva M. Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H. Falkenburger

Publikováno v: Biomolecules, Vol 14, Iss 7, p 756 (2024)

Aggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegenerati

Externí odkaz: https://doaj.org/article/56e384f27b224c169fcf2c4f39ceedc3

Maturing Autophagosomes are Transported Towards the Cell Periphery

Autor: Elisabeth Dinter, Diana Cozma, Björn H. Falkenburger, Theodora Saridaki, Eva M. Szegö, Anna Maria Hilverling

Publikováno v: Cellular and Molecular Neurobiology
Cellular and molecular neurobiology 42(1), 155-171 (2022). doi:10.1007/s10571-021-01116-0
Cellular and molecular neurobiology 42, 155-171 (2022). doi:10.1007/s10571-021-01116-0

Cellular and molecular neurobiology 42, 155-171 (2022). doi:10.1007/s10571-021-01116-0
Published by Springer Science + Business Media B.V, Dordrecht

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b5010f448c6f241c94a7823fe27b1c

Targeting the N-terminus of α-synuclein Monomer Reduces Fibril-induced Aggregation in the Brain

Autor: Michael M. Wördehoff, Wolfgang Hoyer, Charlott Gärtner, Theodora Saridaki, Daniel Komnig, Eva M. Szegö, Fabian Boß, Éva M. Szegő, Hamed Shaykhalishahi, Lennart Höfs, Björn H. Falkenburger, Jörg B. Schulz

Background Removing α-synuclein aggregates or preventing their formation constitutes a plausible strategy against Parkinson’s disease (PD). As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f97f05f5b74d233b2ed4ae2132f2075
https://doi.org/10.21203/rs.3.rs-41606/v1

A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons

Autor: Éva M. Szegő, Fabian Boß, Daniel Komnig, Charlott Gärtner, Lennart Höfs, Hamed Shaykhalishahi, Michael M. Wördehoff, Theodora Saridaki, Jörg B. Schulz, Wolfgang Hoyer, Björn H. Falkenburger

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduc

Externí odkaz: https://doaj.org/article/4afc3502a31946d28cb7ee107aa29503

Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies

Autor: Éva M. Szegő, Antonio Dominguez-Meijide, Ellen Gerhardt, Annekatrin König, David J. Koss, Wen Li, Raquel Pinho, Christiane Fahlbusch, Mary Johnson, Patricia Santos, Anna Villar-Piqué, Tobias Thom, Silvio Rizzoli, Matthias Schmitz, Jiayi Li, Inga Zerr, Johannes Attems, Olaf Jahn, Tiago F. Outeiro

Publikováno v: Cell Reports, Vol 28, Iss 1, Pp 65-77.e6 (2019)

Summary: Alpha-synuclein (aSyn) accumulates in intracellular inclusions in synucleinopathies, but the molecular mechanisms leading to disease are unclear. We identify the 10 kDa heat shock protein (HSP10) as a mediator of aSyn-induced mitochondrial i

Externí odkaz: https://doaj.org/article/4a2e2c417fdf4144aa56a9b613fab5a7