Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Eva M. Jimenez‐Mateos"'
Autor:
Edward Beamer, Mary Isabel O’Dea, Aisling A. Garvey, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Andreea Pavel, Sean Quinlan, Mariana Alves, Eva M. Jimenez-Mateos, Faming Tian, Eugene Dempsey, Nicholas Dale, Deirdre M. Murray, Geraldine B. Boylan, Eleanor J. Molloy, Tobias Engel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restri
Externí odkaz:
https://doaj.org/article/4c4169f8cffe40b7886c3d20474c926c
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2740 (2022)
Brain development occurs until adulthood, with time-sensitive processes happening during embryo development, childhood, and puberty. During early life and childhood, dynamic changes in the brain are critical for physiological brain maturation, and th
Externí odkaz:
https://doaj.org/article/b1913d86414e46739128624709263783
Autor:
Gary P. Brennan, Sebastian Bauer, Tobias Engel, Eva M. Jimenez-Mateos, Federico Del Gallo, Thomas D.M. Hill, Niamh M.C. Connolly, Lara S. Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R. Reschke, Norman Delanty, Jochen H.M. Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C. Henshall
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105048- (2020)
Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient and family history, MRI-imaging and EEG monitoring. There is therefore an unmet clinical need for a non-invasive, molecular-based, biomarker to either predic
Externí odkaz:
https://doaj.org/article/072c418aab5a4a749a92db661a9cf3ff
Autor:
Giorgia Conte, Ngoc T. Nguyen, Mariana Alves, Laura de Diego-Garcia, Aidan Kenny, Annette Nicke, David C. Henshall, Eva M. Jimenez-Mateos, Tobias Engel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell death, neuronal plasticity and the release of neurotransmitters. Accordingly, th
Externí odkaz:
https://doaj.org/article/df40d949865e45408aa3b5f6c5ee9164
Autor:
Rana Raoof, Eva M. Jimenez-Mateos, Sebastian Bauer, Björn Tackenberg, Felix Rosenow, Johannes Lang, Müjgan Dogan Onugoren, Hajo Hamer, Tessa Huchtemann, Peter Körtvélyessy, Niamh M. C. Connolly, Shona Pfeiffer, Jochen H. M. Prehn, Michael A. Farrell, Donncha F. O’Brien, David C. Henshall, Catherine Mooney
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract There is a need for diagnostic biomarkers of epilepsy and status epilepticus to support clinical examination, electroencephalography and neuroimaging. Extracellular microRNAs may be potentially ideal biomarkers since some are expressed uniqu
Externí odkaz:
https://doaj.org/article/9b6edaff4d2b4010b13e449a8ada68c7
Autor:
Hazel McArdle, Eva M. Jimenez-Mateos, Rana Raoof, Eadaoin Carthy, David Boyle, Hany ElNaggar, Norman Delanty, Hajo Hamer, Muejgdan Dogan, Tessa Huchtemann, Peter Kӧrtvelyessy, Felix Rosenow, Robert J. Forster, David C. Henshall, Elaine Spain
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Diagnosis of seizure disorders such as epilepsy currently relies on clinical examination and electroencephalogram recordings and is associated with substantial mis-diagnosis. The miRNA, miR-134 (MIR134 in humans), has been found to be elevat
Externí odkaz:
https://doaj.org/article/82ad782d772448c6aa8e45ae4ebd31e4
Autor:
Sean Quinlan, Paula Merino-Serrais, Alessandra Di Grande, Heiko Dussmann, Jochen H. M. Prehn, Tríona Ní Chonghaile, David C. Henshall, Eva M. Jimenez-Mateos
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent studies suggest that mild hypoxia-induced neonatal seizures can trigger an acute neuroinflammatory response leading to long-lasting changes in brain excitability along with associated cognitive and behavioral deficits. The cellular elements an
Externí odkaz:
https://doaj.org/article/55e4f4013e064808ac58e126559dbf5c
Autor:
Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, Tobias Engel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Prolonged seizures (status epilepticus, SE) may drive hippocampal dysfunction and epileptogenesis, at least partly, through an elevation in neurogenesis, dysregulation of migration and aberrant dendritic arborization of newly-formed neurons. MicroRNA
Externí odkaz:
https://doaj.org/article/19234c54086942beaaaf52c8affce5f5
Autor:
Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W. Danielson, Kristen T. Thomas, Eva M. Jimenez-Mateos, Lindsay M. Schroeder, Raymund Y.K. Pun, Steve C. Danzer, David C. Henshall, Gary J. Bassell
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 37-45 (2016)
Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, i
Externí odkaz:
https://doaj.org/article/1115fba5355d4bb8aa6621fd1f487c00
Autor:
Natalia Rodriguez-Alvarez, Eva M. Jimenez-Mateos, Mark Dunleavy, John L. Waddington, Geraldine B. Boylan, David C. Henshall
Publikováno v:
Neurobiology of Disease, Vol 83, Iss , Pp 100-114 (2015)
Seizures are common during the neonatal period, often due to hypoxic–ischemic encephalopathy and may contribute to acute brain injury and the subsequent development of cognitive deficits and childhood epilepsy. Here we explored short- and long-term
Externí odkaz:
https://doaj.org/article/1cd4e37bb0a94c5bb4280d978293e5e4