Výsledky vyhledávání - "Eva M. Janssen"

Akademický článek

Recognizing biased reasoning: Conflict detection during decision-making and decision-evaluation

Autor: Eva M. Janssen, Samuël B. Velinga, Wim de Neys, Tamara van Gog

Publikováno v: Acta Psychologica, Vol 217, Iss , Pp 103322- (2021)

Although it is well established that our thinking can often be biased, the precise cognitive mechanisms underlying these biases are still debated. The present study builds on recent research showing that biased reasoners often seem aware that their r

Externí odkaz: https://doaj.org/article/587eada41a454d0aba697eb6ae7ad177

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Akademický článek

Effects of Self-Explaining on Learning and Transfer of Critical Thinking Skills

Autor: Lara M. van Peppen, Peter P. J. L. Verkoeijen, Anita E. G. Heijltjes, Eva M. Janssen, Denise Koopmans, Tamara van Gog

Publikováno v: Frontiers in Education, Vol 3 (2018)

Critical thinking is considered to be an important competence for students and graduates of higher education. Yet, it is largely unclear which teaching methods are most effective in supporting the acquisition of critical thinking skills, especially r

Externí odkaz: https://doaj.org/article/f752137c58ab42e09d10c4210bf7eb00

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Akademický článek

Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4

Autor: Jonas Nørskov Søndergaard, Simon J. van Heeringen, Maaike W. G. Looman, Chunling Tang, Vassilis Triantis, Pauline Louche, Eva M. Janssen-Megens, Anieta M. Sieuwerts, John W. M. Martens, Colin Logie, Hendrik G. Stunnenberg, Marleen Ansems, Gosse J. Adema

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Dendritic cell (DC)-based immunotherapy makes use of the DC’s ability to direct the adaptive immune response toward activation or inhibition. DCs perform this immune orchestration in part by secretion of selected cytokines. The most potent anti-inf

Externí odkaz: https://doaj.org/article/ddbaab4a79cd4ec38bc9f51fd0f60db0

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Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (9), ⟨10.1084/jem.20192360⟩
Journal of Experimental Medicine, 2020, 217 (9), ⟨10.1084/jem.20192360⟩
Journal of Experimental Medicine, 217, 9, pp. 1-28
Journal of Experimental Medicine, 217, 1-28

This manuscript presents a comprehensive epigenomic analysis of human thymocyte development and provides new molecular insights into the mechanism by which the TCRA enhancer is activated during thymic maturation by developmentally programmed repressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de66f73e71e66697e93213ace5c73bfa
http://hdl.handle.net/10230/45880

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Combined HAT/EZH2 modulation leads to cancer-selective cell death

Publikováno v: Oncotarget, 9, 39, pp. 25630-25646
Oncotarget
Oncotarget, Impact journals, 2018, 9 (39), pp.25630-25646. ⟨10.18632/oncotarget.25428⟩
Oncotarget 9 (2018): 25630–25646. doi:10.18632/oncotarget.25428
info:cnr-pdr/source/autori:Petraglia F.; Singh A.A.; Carafa V.; Nebbioso A.; Conte M.; Scisciola L.; Valente S.; Baldi A.; Mandoli A.; Petrizzi V.B.; Ingenito C.; De Falco S.; Cicatiello V.; Apicella I.; Janssen-Megens E.M.; Kim B.; Yi G.; Logie C.; Heath S.; Ruvo M.; Wierenga A.T.J.; Flicek P.; Yaspo M.L.; Della Valle V.; Bernard O.; Tomassi S.; Novellino E.; Feoli A.; Sbardella G.; Gut I.; Vellenga E.; Stunnenberg H.G.; Mai A.; Martens J.H.A.; Altucci L./titolo:Combined HAT%2FEZH2 modulation leads to cancer-selective cell death/doi:10.18632%2Foncotarget.25428/rivista:Oncotarget/anno:2018/pagina_da:25630/pagina_a:25646/intervallo_pagine:25630–25646/volume:9
Oncotarget, 9(39), 25630-25646. Impact Journals LLC
Oncotarget, 9, 25630-25646

Contains fulltext : 197351.pdf (Publisher’s version ) (Open Access) Epigenetic alterations have been associated with both pathogenesis and progression of cancer. By screening of library compounds, we identified a novel hybrid epi-drug MC2884, a HAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdda9d466d39d40700157108aaadbeaf
https://hdl.handle.net/2066/197351

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C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation

Publikováno v: Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.
Leukemia, 32(3), 828-836. Nature Publishing Group
Leukemia, 32, pp. 828-836
Leukemia, 32, 828-836. Macmillan Publishers Limited, part of Springer Nature.
Leukemia, 32(3), 828-836

Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter enriched for active chromatin marks in BRE intron 4 causing strong biall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0991d6d688f32e57394edc14b63b95c
https://doi.org/10.1038/leu.2017.280

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Single cell transcriptome atlas of immune cells in human small intestine and in celiac disease

Autor: Anna Bujko, Henk Stunnenberg, Jørgen Jahnsen, Peter Brazda, Espen S. Baekkevold, Nader Atlasy, Eva M. Janssen-Megens, Frode L. Jahnsen

Celiac disease (CeD) is an autoimmune disorder in which ingestion of dietary gluten triggers an immune reaction in the small intestine1,2. The CeD lesion is characterized by crypt hyperplasia, villous atrophy and chronic inflammation with accumulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1d623f971679722bd8de6188023d82

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The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

Autor: Guoqiang Yi, Branco M. H. Heuts, Francesco Ferrari, Jan Jacob Schuringa, Eva M. Janssen-Megens, Esther Tijchon, Amit Mandoli, Jos G. A. Smits, Bowon Kim, Falco Wijnen, Joost H.A. Martens

Publikováno v: PLoS One, 14
PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
PLoS One, 14, 12
PLoS ONE
PLoS ONE, 14(12):0226435. PUBLIC LIBRARY SCIENCE

Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca67d382a738dc1f542cb251b0e26df
http://hdl.handle.net/2066/219175

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Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4

Autor: Simon J. van Heeringen, Maaike W. G. Looman, Colin Logie, Anieta M. Sieuwerts, Hendrik G. Stunnenberg, Gosse J. Adema, Marleen Ansems, Vassilis Triantis, Jonas Nørskov Søndergaard, Eva M. Janssen-Megens, John W.M. Martens, Pauline Louche, Chunling Tang

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 9
Frontiers in Immunology, 9:1420. Frontiers Media S.A.

Dendritic cell (DC)-based immunotherapy makes use of the DC's ability to direct the adaptive immune response toward activation or inhibition. DCs perform this immune orchestration in part by secretion of selected cytokines. The most potent anti-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d96f0390cfb1dc7f1c682d499e5d2ec
https://www.frontiersin.org/article/10.3389/fimmu.2018.01420/full

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Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

Publikováno v: Cell reports
Cell reports, 24(10), 2784-2794. Cell Press
Cell Reports, 24(10), 2784-2794. Cell Press
Cell Reports, 24, 10, pp. 2784-2794
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports, 24, 2784-2794
Cell Reports
Grassi, L, Pourfarzad, F, Ullrich, S, Merkel, A, Were, F, Carrillo-de-Santa-Pau, E, Yi, G, Hiemstra, I H, Tool, A T J, Mul, E, Perner, J, Janssen-Megens, E, Berentsen, K, Kerstens, H, Habibi, E, Gut, M, Yaspo, M L, Linser, M, Lowy, E, Datta, A, Clarke, L, Flicek, P, Vingron, M, Roos, D, van den Berg, T K, Heath, S, Rico, D, Frontini, M, Kostadima, M, Gut, I, Valencia, A, Ouwehand, W H, Stunnenberg, H G, Martens, J H A & Kuijpers, T W 2018, ' Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils ', Cell Reports, vol. 24, no. 10, pp. 2784-2794 . https://doi.org/10.1016/j.celrep.2018.08.018
Cell Reports, Vol 24, Iss 10, Pp 2784-2794 (2018)

Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f193892e55a888b2263c2f184382ea9b
https://pubmed.ncbi.nlm.nih.gov/30184510

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