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Antiproliferative Activity of Functionalized Histidine‐derived Au(I) bis‐NHC Complexes for Bioconjugation

Autor: Tobias O. Berghausen, João D. G. Correia, Fritz E. Kühn, Eva M. Hahn, Teresa Pinheiro, Robert M. Reich, Fernanda Marques, Bruno Dominelli, Christian H. G. Jakob

Publikováno v: Chemistry, an Asian Journal

A series of histidine derived Au(I) bis‐NHC complexes bearing different ester, amide and carboxylic acid functionalities as well as wingtip substituents is synthesized and characterized. The stability in aqueous media, in vitro cytotoxicity in a se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eae16e4e6fbd81aac5a8209e8d7428
http://europepmc.org/articles/PMC7689731

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Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells

Autor: Angela Casini, Natalia Estrada-Ortiz, Eva M. Hahn, Vera F. C. Ferreira, Fritz E. Kühn, Tobias G. Kapp, Jiaying Han, João D. G. Correia

Publikováno v: European Journal of Inorganic Chemistry, 2017(12), 1667-1672. WILEY-V C H VERLAG GMBH

The lack of selectivity for cancer cells and the resulting\ud negative impact on healthy tissue is a severe drawback of actual\ud cancer chemotherapy. Tethering of cytotoxic drugs to targeting\ud vectors such as peptides, which recognize receptors ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4510c4a74696bfec9f7ca540c57a8afb
https://doi.org/10.1002/ejic.201601094

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Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals

Autor: Eva M. Hahn, Angela Casini, Fritz E. Kuehn

Publikováno v: Coordination Chemistry Reviews. 276:97-111

Tc(VII) and Re(VII) trioxo complexes are currently arousing interest because of their potential use as radiopharmaceuticals due to their hydrophilic character and stability in a biological environment. The radioactive isotopes Tc-99m and Re-188 are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3000de8ca1f0410649c12f2328a421c
https://doi.org/10.1016/j.ccr.2014.05.021

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Making oxidation potentials predictable: coordination of additives applied to the electronic fine tuning of an iron(II) complex

Autor: Fritz E. Kühn, Alexander Pöthig, Stefan Haslinger, Eva M. Hahn, Mirza Cokoja, Jean-Marie Basset, Jens W. Kück

Publikováno v: Inorganic chemistry. 53(21)

This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2812d4d30be0c2f6392c9dd5a4215e90
https://pubmed.ncbi.nlm.nih.gov/25333790

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