Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Eva M. Goellner"'
Autor:
Hannah G. Daniels, Breanna G. Knicely, Anna Kristin Miller, Ana Thompson, Rina Plattner, Eva M. Goellner
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The DNA mismatch repair (MMR) pathway and its regulation are critical for genomic stability. Mismatch repair (MMR) follows replication and repairs misincorporated bases and small insertions or deletions that are not recognized and removed by the proo
Externí odkaz:
https://doaj.org/article/bb28fe98fae9483a8b00feba2402e5c5
Autor:
Anna K. Miller, Guogen Mao, Breanna G. Knicely, Hannah G. Daniels, Christine Rahal, Christopher D. Putnam, Richard D. Kolodner, Eva M. Goellner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
DNA mismatch repair (MMR) repairs replication errors, and MMR defects play a role in both inherited cancer predisposition syndromes and in sporadic cancers. MMR also recognizes mispairs caused by environmental and chemotherapeutic agents; however, in
Externí odkaz:
https://doaj.org/article/bfb164c88c9b4e268af71739856dca78
ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Autor:
Elise Fouquerel, Eva M. Goellner, Zhongxun Yu, Jean-Philippe Gagné, Michelle Barbi de Moura, Tim Feinstein, David Wheeler, Philip Redpath, Jianfeng Li, Guillermo Romero, Marie Migaud, Bennett Van Houten, Guy G. Poirier, Robert W. Sobol
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1819-1831 (2014)
ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated wit
Externí odkaz:
https://doaj.org/article/57881395c3964d75997386db9b9b638b
Autor:
Robert W. Sobol, Ashley R. Brown, David Svilar, Elena Jelezcova, Claudette M. St Croix, Ram N. Trivedi, Xiao-hong Wang, Eva M. Goellner, Jiang-bo Tang
Base excision repair (BER) protein expression is important for resistance to DNA damage–induced cytotoxicity. Conversely, BER imbalance [DNA polymerase β (Polβ) deficiency or repair inhibition] enhances cytotoxicity of radiation and chemotherapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7291a9fb8906b99625f969ff9406a0
https://doi.org/10.1158/1541-7786.c.6541945.v1
https://doi.org/10.1158/1541-7786.c.6541945.v1
Autor:
Robert W. Sobol, Ashley R. Brown, David Svilar, Elena Jelezcova, Claudette M. St Croix, Ram N. Trivedi, Xiao-hong Wang, Eva M. Goellner, Jiang-bo Tang
Supplementary Data from Bioenergetic Metabolites Regulate Base Excision Repair–Dependent Cell Death in Response to DNA Damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f28120e37456dba5965c4c9bed0377c
https://doi.org/10.1158/1541-7786.22518490.v1
https://doi.org/10.1158/1541-7786.22518490.v1
Autor:
Robert W. Sobol, Jiang-bo Tang, Ram N. Trivedi, Leah Mitchell, Kelsey F. Sugrue, Xiao-Hong Wang, Ying-Chih Lin, Ashley R. Brown, Bradford Grimme, Eva M. Goellner
Glioblastoma multiforme (GBM) is a devastating brain tumor with poor prognosis and low median survival time. Standard treatment includes radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). However, a large percentage of tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e44da0e46c7b13db68b335141cd672
https://doi.org/10.1158/0008-5472.c.6503126.v1
https://doi.org/10.1158/0008-5472.c.6503126.v1
Autor:
Robert W. Sobol, Jiang-bo Tang, Ram N. Trivedi, Leah Mitchell, Kelsey F. Sugrue, Xiao-Hong Wang, Ying-Chih Lin, Ashley R. Brown, Bradford Grimme, Eva M. Goellner
Supplementary Methods, Figures 1-6, Table 1 from Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6178cbcb02e7884cc2cd0dff6640ebed
https://doi.org/10.1158/0008-5472.22391033
https://doi.org/10.1158/0008-5472.22391033
Autor:
Anna K, Miller, Guogen, Mao, Breanna G, Knicely, Hannah G, Daniels, Christine, Rahal, Christopher D, Putnam, Richard D, Kolodner, Eva M, Goellner
DNA mismatch repair (MMR) repairs replication errors, and MMR defects play a role in both inherited cancer predisposition syndromes and in sporadic cancers. MMR also recognizes mispairs caused by environmental and chemotherapeutic agents; however, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52773b6ae67722b5dfe4a174728c0148
https://escholarship.org/uc/item/7ck6t6xt
https://escholarship.org/uc/item/7ck6t6xt
Publikováno v:
Cancer Research. 82:1516-1516
The DNA mismatch repair (MMR) pathway and its regulation are necessary for genomic stability. Cells deficient in MMR exhibit increased expansion and contraction of short repeat sequences in the genome, termed microsatellite instability (MSI). Loss of
Autor:
Eva M. Goellner
Publikováno v:
DNA Repair (Amst)
DNA mismatch repair (MMR) increases replication fidelity and genome stability by correcting DNA polymerase errors that remain after replication. Defects in MMR result in the accumulation of mutations and lead to human tumor development. Germline muta