Výsledky vyhledávání - "Eva M. Frickel"

Akademický článek

Differential development of antibiotic resistance and virulence between Acinetobacter species

Autor: Elizabeth M. Darby, Robert A. Moran, Emma Holden, Theresa Morris, Freya Harrison, Barbara Clough, Ross S. McInnes, Ludwig Schneider, Eva M. Frickel, Mark A. Webber, Jessica M. A. Blair

Publikováno v: mSphere, Vol 9, Iss 5 (2024)

ABSTRACT The two species that account for most cases of Acinetobacter-associated bacteremia in the United Kingdom are Acinetobacter lwoffii, often a commensal but also an emerging pathogen, and Acinetobacter baumannii, a well-known antibiotic-resista

Externí odkaz: https://doaj.org/article/8d374d5b7f504bbaa70c039e941064e4

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Akademický článek

Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

Autor: Anthony S. Piro, Dulcemaria Hernandez, Sarah Luoma, Eric M. Feeley, Ryan Finethy, Azeb Yirga, Eva M. Frickel, Cammie F. Lesser, Jörn Coers

Publikováno v: mBio, Vol 8, Iss 6 (2017)

ABSTRACT Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFN-γ)-inducible host defense proteins that can associate with cytosol-invading bacterial pathogens. Mouse GBPs promote the lytic destruction of targeted bacteria in the h

Externí odkaz: https://doaj.org/article/51771ab8e9bf43aaa2843d2a7d4c7174

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Cellular barcoding of protozoan pathogens reveals the within-host population dynamics of Toxoplasma gondii host colonization

Autor: Ceire J. Wincott, Gayathri Sritharan, Henry J. Benns, Farzana B. Liakath, Carla Gilabert-Carbajo, Monique Bunyan, Aisling R. Fairweather, Eduardo Alves, Ivan Andrew, Laurence Game, Eva M. Frickel, Calvin Tiengwe, Sarah E. Ewald, Matthew A. Child

Molecular barcoding techniques have emerged as powerful tools to understand microbial pathogenesis. However, barcoding strategies have not been extended to protozoan parasites, which have unique genomic structures and virulence strategies compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e48515ef71998e8a50da733382ffbfc

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In vivo control of Toxoplasma gondii by zebrafish macrophages

Autor: Jason Mercer, Eva M. Frickel, Nagisa Yoshida, Marie-Charlotte Domart, Lucy M. Collinson, Artur Yakimovich, Serge Mostowy, Maria J. Mazon-Moya

Toxoplasma gondii is an obligate intracellular parasite capable of invading any nucleated cell. Three main clonal lineages (type I, II, III) exist and murine models have driven the understanding of general and strain-specific immune mechanisms underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77ebe592f8f54d727149aaa1ec157bc
https://doi.org/10.1101/828624

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Mimicry embedding for advanced neural network training of 3D biomedical micrographs

Autor: Eva M. Frickel, Jerzy Samolej, Artur Yakimovich, Serge Mostowy, Nagisa Yoshida, Barbara Clough, Moona Huttunen, Jason Mercer

The use of deep neural networks (DNNs) for analysis of complex biomedical images shows great promise but is hampered by a lack of large verified datasets for rapid network evolution. Here we present a novel “mimicry embedding” strategy for rapid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3e20e91bb0fa328a71fc95b4d57412

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Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)

Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca6933c962605b485eed723112b99d4

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Author response: Defining host–pathogen interactions employing an artificial intelligence workflow

Autor: Eva M. Frickel, Joseph Wright, Artur Yakimovich, Jason Mercer, Monique Bunyan, Daniel Fisch, Barbara Clough, Michael Howell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b1a9c4b67f4a9f8aaf895d36fa675f7
https://doi.org/10.7554/elife.40560.021

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Detection of Cytosolic

Autor: Anthony S, Piro, Dulcemaria, Hernandez, Sarah, Luoma, Eric M, Feeley, Ryan, Finethy, Azeb, Yirga, Eva M, Frickel, Cammie F, Lesser, Jörn, Coers

Publikováno v: mBio

Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFN-γ)-inducible host defense proteins that can associate with cytosol-invading bacterial pathogens. Mouse GBPs promote the lytic destruction of targeted bacteria in the host cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0b1628d501151197ad16b01eb4de45a
https://pubmed.ncbi.nlm.nih.gov/29233899

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IRG and GBP host resistance factors target aberrant, ‘‘Non-self’’ vacuoles characterized by the missing of ‘‘Self’’ IRGM proteins

Autor: Jörn Coers, Joe Dan Dunn, Anthony S. Piro, Arun K. Haldar, Eva M. Frickel, Gregory A. Taylor, Hector Alex Saka, Raphael H. Valdivia, Stanley C. Henry

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens
PLoS Pathogens, Vol 9, Iss 6, p e1003414 (2013)

Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic microbes. IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5021694d6b52865589537b6a2e7f4a5
http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003414

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