Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Eva M. DiLeo"'
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 572:352-359
N-(n-Propyl)-N-(4-pyridinyl)-1H-indol-1-amine hydrochloride (HP 749, I), a non-receptor-dependent cholinomimetic agent with noradrenergic activity, is a potential agent for the treatment of Alzheimer's disease. Pharmacokinetic studies in animals and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf26237a015035ef005a7d688ba6982f
https://doi.org/10.1016/0378-4347(91)80503-5
https://doi.org/10.1016/0378-4347(91)80503-5
Autor:
Thomas H. Hintze, Lynne Griffiths, Chandra Natarajan, Robert S. Hsu, Roosevelt Dean, Eva M. DiLeo, John W. Hubbard
Publikováno v:
Journal of clinical pharmacology. 35(7)
HP 749 was absorbed slowly in the conscious monkey after single oral doses (10, 20, and 40 mg/kg), with gradual metabolism to the N-despropyl metabolite, P86-7480. The tmax was 2 to 4 hours after dosing, with nonlinear increases in Cmax and the AUC0-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85f48efdd0d5c38c7c9b0910c24adb1
https://pubmed.ncbi.nlm.nih.gov/7560249
https://pubmed.ncbi.nlm.nih.gov/7560249
Publikováno v:
Journal of chromatography. 530(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08acb1a91a65e21dac0e8aeb554c6f5
https://pubmed.ncbi.nlm.nih.gov/2277108
https://pubmed.ncbi.nlm.nih.gov/2277108
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 494:347-353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0295f0ba5f0e23952b4092943034cc
https://doi.org/10.1016/s0378-4347(00)82687-0
https://doi.org/10.1016/s0378-4347(00)82687-0