Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Eva M, Trinidad"'
RANK is a poor prognosis marker and a therapeutic target in ER‐negative postmenopausal breast cancer
Autor:
Marina Ciscar, Eva M Trinidad, Gema Perez‐Chacon, Mansour Alsaleem, Maria Jimenez, Maria J Jimenez‐Santos, Hector Perez‐Montoyo, Adrian Sanz‐Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T Soler‐Monso, Victor Lopez, Jorge Gomez‐Miragaya, Clara Gomez‐Aleza, Lacey E Dobrolecki, Michael T Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela‐Fandino, Fatima Al‐Shahrour, Antonio Martinez‐Aranda, Angels Sierra, Andrew R Green, Emad Rakha, Eva Gonzalez‐Suarez
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-12 (2023)
Abstract Despite strong preclinical data, the therapeutic benefit of the RANKL inhibitor, denosumab, in breast cancer patients, beyond the bone, is unclear. Aiming to select patients who may benefit from denosumab, we hereby analyzed RANK and RANKL p
Externí odkaz:
https://doaj.org/article/1a7e932a6a184ce6a384d4a58e43a0be
Autor:
Clara Gómez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernández-Jiménez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M. Trinidad, Sandra Benítez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, Gert Van den Eynden, Chloé Velghe, Françoise Rothé, Karen Willard-Gallo, Stefan Michiels, Purificación Muñoz, Thierry Walzer, Lourdes Planelles, Josef Penninger, Hatem A. Azim, Sherene Loi, Martine Piccart, Christos Sotiriou, Eva González-Suárez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that
Externí odkaz:
https://doaj.org/article/25343e5b801f4662be448798ebe81a76
Autor:
Eva González-Suárez, Xose S. Puente, Michael T. Lewis, Miguel Angel Pujana, Violeta Serra, Cristina Cruz, Judith Balmaña, Anna Petit, María Teresa Soler-Monso, Joaquín Arribas, Carlos Caldas, Alejandra Bruna, Aleix Prat, Laia Paré, Purificación Muñoz, Eva M. Trinidad, Alejandro Collado-Sole, Gerburg M. Wulf, Bing Zhang, Suhas Vasaikar, Chen Huang, Lacey E. Dobrolecki, Marta Palafox, Luis Palomero, Sergi Beltran, Raul Tonda, Ander Díaz-Navarro, Jorge Gómez-Miragaya
Supplementary methods and legends for supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c459f478caf89ee13f2a4d0789fe97
https://doi.org/10.1158/0008-5472.22421748.v1
https://doi.org/10.1158/0008-5472.22421748.v1
Autor:
Eva González-Suárez, Xose S. Puente, Michael T. Lewis, Miguel Angel Pujana, Violeta Serra, Cristina Cruz, Judith Balmaña, Anna Petit, María Teresa Soler-Monso, Joaquín Arribas, Carlos Caldas, Alejandra Bruna, Aleix Prat, Laia Paré, Purificación Muñoz, Eva M. Trinidad, Alejandro Collado-Sole, Gerburg M. Wulf, Bing Zhang, Suhas Vasaikar, Chen Huang, Lacey E. Dobrolecki, Marta Palafox, Luis Palomero, Sergi Beltran, Raul Tonda, Ander Díaz-Navarro, Jorge Gómez-Miragaya
Docetaxel response on TNBC cell lines with ETV6 and GABARAPL1 overexpression and knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8c8345a1ddeb9a7b70d6b65550935a
https://doi.org/10.1158/0008-5472.22421757
https://doi.org/10.1158/0008-5472.22421757
Autor:
Eva González-Suárez, Xose S. Puente, Michael T. Lewis, Miguel Angel Pujana, Violeta Serra, Cristina Cruz, Judith Balmaña, Anna Petit, María Teresa Soler-Monso, Joaquín Arribas, Carlos Caldas, Alejandra Bruna, Aleix Prat, Laia Paré, Purificación Muñoz, Eva M. Trinidad, Alejandro Collado-Sole, Gerburg M. Wulf, Bing Zhang, Suhas Vasaikar, Chen Huang, Lacey E. Dobrolecki, Marta Palafox, Luis Palomero, Sergi Beltran, Raul Tonda, Ander Díaz-Navarro, Jorge Gómez-Miragaya
Taxanes are the mainstay of treatment in triple-negative breast cancer (TNBC), with de novo and acquired resistance limiting patient's survival. To investigate the genetic basis of docetaxel resistance in TNBC, exome sequencing was performed on match
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98573ba4edc3d2e2455e34f8453a5f5e
https://doi.org/10.1158/0008-5472.c.6511020
https://doi.org/10.1158/0008-5472.c.6511020
Autor:
Eva González-Suárez, Xose S. Puente, Michael T. Lewis, Miguel Angel Pujana, Violeta Serra, Cristina Cruz, Judith Balmaña, Anna Petit, María Teresa Soler-Monso, Joaquín Arribas, Carlos Caldas, Alejandra Bruna, Aleix Prat, Laia Paré, Purificación Muñoz, Eva M. Trinidad, Alejandro Collado-Sole, Gerburg M. Wulf, Bing Zhang, Suhas Vasaikar, Chen Huang, Lacey E. Dobrolecki, Marta Palafox, Luis Palomero, Sergi Beltran, Raul Tonda, Ander Díaz-Navarro, Jorge Gómez-Miragaya
Supplementary Table S1. Models, point mutations and CNA Supplementary Table S2. Differentially expressed genes, pathways and co-occurrence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9c874c83d95ae28fdf557fd4a36fd4
https://doi.org/10.1158/0008-5472.22421751
https://doi.org/10.1158/0008-5472.22421751
Autor:
Eva González-Suárez, Lourdes Planelles, Miguel-Angel Pujana, Purificación Muñoz, William C. Dougall, Jordi Serra-Musach, Jorge Gomez-Miragaya, Alex Cordero, Eva M. Trinidad, Pasquale Pellegrini, Guillermo Yoldi
Legend for Supplementary Table S1 and Supplementary Figures S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8e7df58d3ed33c36c982b0dedddf59
https://doi.org/10.1158/0008-5472.22408430.v1
https://doi.org/10.1158/0008-5472.22408430.v1
Autor:
Eva González-Suárez, Lourdes Planelles, Miguel-Angel Pujana, Purificación Muñoz, William C. Dougall, Jordi Serra-Musach, Jorge Gomez-Miragaya, Alex Cordero, Eva M. Trinidad, Pasquale Pellegrini, Guillermo Yoldi
Knock-down and overexpression of Tfap2b and Knock down of Rank
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03eed525a038e3ba91be3df2865aaef0
https://doi.org/10.1158/0008-5472.22408442.v1
https://doi.org/10.1158/0008-5472.22408442.v1
Autor:
Eva González-Suárez, Lourdes Planelles, Miguel-Angel Pujana, Purificación Muñoz, William C. Dougall, Jordi Serra-Musach, Jorge Gomez-Miragaya, Alex Cordero, Eva M. Trinidad, Pasquale Pellegrini, Guillermo Yoldi
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdcd747924fdd9cc09782795aaf8948
https://doi.org/10.1158/0008-5472.22408436
https://doi.org/10.1158/0008-5472.22408436
Autor:
Eva González-Suárez, Lourdes Planelles, Miguel-Angel Pujana, Purificación Muñoz, William C. Dougall, Jordi Serra-Musach, Jorge Gomez-Miragaya, Alex Cordero, Eva M. Trinidad, Pasquale Pellegrini, Guillermo Yoldi
RANK expression is associated with poor prognosis in breast cancer even though its therapeutic potential remains unknown. RANKL and its receptor RANK are downstream effectors of the progesterone signaling pathway. However, RANK expression is enriched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4683296f424049bd54c2ec9d3ccf6a32
https://doi.org/10.1158/0008-5472.c.6507533
https://doi.org/10.1158/0008-5472.c.6507533