Zobrazeno 1 - 10
of 691
pro vyhledávání: '"Eva L. Feldman"'
Autor:
Evan L. Reynolds, Kristen Votruba, Clifford R. Jack, Richard Beare, Robert I. Reid, Gregory M. Preboske, Camille Waseta, Rodica Pop‐Busui, Robert G. Nelson, Brian C. Callaghan, Eva L. Feldman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1891-1898 (2023)
Abstract We performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T
Externí odkaz:
https://doaj.org/article/a9893f84b94643a29c51aee3139dd69a
Autor:
Kevin S. Chen, Mohamed H. Noureldein, Lisa M. McGinley, John M. Hayes, Diana M. Rigan, Jacquelin F. Kwentus, Shayna N. Mason, Faye E. Mendelson, Masha G. Savelieff, Eva L. Feldman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionStem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidat
Externí odkaz:
https://doaj.org/article/34fd950a9d53474a8e6ce622502373c2
Autor:
Bhumsoo Kim, Yoon‐Tae Kang, Faye E. Mendelson, John M. Hayes, Masha G. Savelieff, Sunitha Nagrath, Eva L. Feldman
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 11, Pp n/a-n/a (2023)
Abstract The metabolic syndrome (MetS) and Alzheimer's disease share several pathological features, including insulin resistance, abnormal protein processing, mitochondrial dysfunction and elevated inflammation and oxidative stress. The MetS constitu
Externí odkaz:
https://doaj.org/article/fdf9cf5f39e64e109131131091c0e1a5
Autor:
Ayşe J. Muñiz, Tuğba Topal, Michael D. Brooks, Angela Sze, Do Hoon Kim, Jacob Jordahl, Joe Nguyen, Paul H. Krebsbach, Masha G. Savelieff, Eva L. Feldman, Joerg Lahann
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 7, Pp 1239-1253 (2023)
Abstract Objective Brain organoids are miniaturized in vitro brain models generated from pluripotent stem cells, which resemble full‐sized brain more closely than conventional two‐dimensional cell cultures. Although brain organoids mimic the huma
Externí odkaz:
https://doaj.org/article/b1f6f864b7bc43ee9871a66f7c532eae
Autor:
Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam M. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur, Eva L. Feldman
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/2f166091904b4861a8f8035e9fd12621
Autor:
Kai Guo, Claudia Figueroa-Romero, Mohamed Noureldein, Lucy M. Hinder, Stacey A. Sakowski, Amy E. Rumora, Hayley Petit, Masha G. Savelieff, Junguk Hur, Eva L. Feldman
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Peripheral neuropathy (PN) is a common complication in obesity, prediabetes, and type 2 diabetes, though its pathogenesis remains incompletely understood. In a murine high-fat diet (HFD) obesity model of PN, dietary reversal (HFD-
Externí odkaz:
https://doaj.org/article/22954bccb663410aa6529fa0582c2fb0
Autor:
Sarah E. Elzinga, Stephanie A. Eid, Brett A. McGregor, Dae-Gyu Jang, Lucy M. Hinder, Jacqueline R. Dauch, John M. Hayes, Hongyu Zhang, Kai Guo, Subramaniam Pennathur, Matthias Kretzler, Frank C. Brosius, Emily J. Koubek, Eva L. Feldman, Junguk Hur
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/d240158514aa40fe8b66d99c549dc073
Autor:
Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam M. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur, Eva L. Feldman
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of cognitive impairment as they age. Immune dysregulation, including inflammaging (e.g., increased
Externí odkaz:
https://doaj.org/article/ab5ac6fbf968468b90d40d48c54120c8
Autor:
Sarah E. Elzinga, Emily J. Koubek, John M. Hayes, A. Carter, Faye E. Mendelson, Ian Webber-Davis, Stephen I. Lentz, Eva L. Feldman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionThe prevalence of obesity, prediabetes, and diabetes continues to grow worldwide. These metabolic dysfunctions predispose individuals to neurodegenerative diseases and cognitive impairment, including dementias such as Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/1fd9916d6ee84d1785c25eb27f1044cc
Autor:
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 9, Pp 1392-1404 (2022)
Abstract Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify indiv
Externí odkaz:
https://doaj.org/article/d318044b851d4b8d8d34b931e9b4f96b