Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eva Kudová"'
Autor:
Alzbeta Stefela, Miroslav Kaspar, Martin Drastik, Thales Kronenberger, Stanislav Micuda, Martin Dracinsky, Blanka Klepetarova, Eva Kudova, Petr Pavek
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor (FXR) and G-protein bile acid receptor 1 (GPBAR1). Extensive medicinal chemistry modifications
Externí odkaz:
https://doaj.org/article/41d6b0e2df9d4724951d8ee7df1dc6a6
Autor:
Eva Kudova, Pavel Mares, Martin Hill, Katerina Vondrakova, Grygoriy Tsenov, Hana Chodounska, Hana Kubova, Karel Vales
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 49 (2021)
Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo. Our in vitro experiments identified PA-G as an inhibitor of N-methyl-D-aspartat
Externí odkaz:
https://doaj.org/article/421a4e406dcf4dc3bc8960197d4845d4
Autor:
Santosh Kumar Adla, Arun Kumar Tonduru, Thales Kronenberger, Eva Kudova, Antti Poso, Kristiina M. Huttunen
Publikováno v:
Molecules, Vol 26, Iss 18, p 5662 (2021)
In this study, we investigated the delivery of synthetic neurosteroids into MCF-7 human breast adenocarcinoma cells via Organic Anionic Transporting Polypeptides (OATPs) (pH 7.4 and 5.5) to identify the structural components required for OATP-mediate
Externí odkaz:
https://doaj.org/article/459abd0c191643a98e6ae5d8bfeffaa0
Autor:
Kristina Holubova, Marketa Chvojkova, Barbora Hrcka Krausova, Vojtech Vyklicky, Eva Kudova, Hana Chodounska, Ladislav Vyklicky, Karel Vales
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1026 (2021)
Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of sch
Externí odkaz:
https://doaj.org/article/d697bc39daff4bd4944bbb038ff09afb
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 791 (2021)
Epipregnanolone (3β-hydroxy-5β-pregnan-20-one, Epi) is an endogenous steroid with important physiological effects and high affinity for GABAA receptors. The effect of Epi on GABA-induced chloride current (IGABA) in native neurons has hardly been st
Externí odkaz:
https://doaj.org/article/63e5747b15574b33ac397c53443cd465
Autor:
Chian-Ru Chern, Marcela Lauková, Antonia Schonwald, Eva Kudová, Hana Chodounská, Chian-Jiang Chern, Michael P. Shakarjian, Jana Velíšková, Libor Velíšek
Publikováno v:
Pharmacological reports : PR.
Neurosteroids are investigated as effective antidotes for the poisoning induced by tetramethylenedisulfotetramine (TMDT) as well as treatments for epileptic spasms during infancy. Both these conditions are quite resistant to pharmacotherapy; thus, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eae317f40b56b84bfe421e6b361d16
https://pubmed.ncbi.nlm.nih.gov/36422805
https://pubmed.ncbi.nlm.nih.gov/36422805
Autor:
Jan Voldřich, Marika Matoušová, Markéta Šmídková, Barbora Slavíková, Hana Chodounská, Eva Kudová, Helena Mertlíková-Kaiserová
Publikováno v:
European journal of pharmacology. 927
The goal of this study was to evaluate mixed cortical and hippocampal primary rat postnatal neuronal culture as in vitro tool for identification of N-methyl-D-aspartate receptor (NMDAR) antagonists and to find out, whether this model is comparable wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fdc0e1a313d57216606a73e86b77b9
https://pubmed.ncbi.nlm.nih.gov/35636520
https://pubmed.ncbi.nlm.nih.gov/35636520
Autor:
Ewa Szczurowska, Eszter Szánti-Pintér, Nikolai Chetverikov, Alena Randáková, Eva Kudová, Jan Jakubík
Publikováno v:
International Journal of Molecular Sciences. 24:507
Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419ef4f5cd50c2415385a2e13fbe07c8
https://doi.org/10.3390/ijms24010507
https://doi.org/10.3390/ijms24010507
Autor:
Michaela Hanzlova, Barbora Slavikova, Marina Morozovova, Kamil Musilek, Aneta Rotterova, Lucie Zemanová, Eva Kudova
Publikováno v:
ACS Omega, Vol 9, Iss 10, Pp 12116-12124 (2024)
Externí odkaz:
https://doaj.org/article/186a3ae2dec24db69630d3513d982d76
Publikováno v:
ACS Omega, Vol 9, Iss 6, Pp 7043-7052 (2024)
Externí odkaz:
https://doaj.org/article/55c2bc600fe84cb8bab6e704b9d22274