Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

Autor: Jos Jonkers, Stephanie H. Davis, Nathalie Conte, Allan Bradley, Peter K. Sorger, Stephanie Z. Xie, Petra L. Bakker, Eva Kregel, Judith E Simon, Floris Foijer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13427-13432. NATL ACAD SCIENCES

Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to

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https://hdl.handle.net/11370/b356c578-46d1-46ff-bbf1-6276a0e24bb8