Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eva Konkolova"'
Autor:
Milan Dejmek, Eva Konkoľová, Luděk Eyer, Petra Straková, Pavel Svoboda, Michal Šála, Kateřina Krejčová, Daniel Růžek, Evzen Boura, Radim Nencka
Publikováno v:
Viruses, Vol 13, Iss 8, p 1585 (2021)
SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding di
Externí odkaz:
https://doaj.org/article/3a4d2127737c462d8b5894cb21b9defc
Autor:
Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnatova, Tomáš Kučera, Petr Bzonek, Nikola Novakova, Daniel Jun, Lucie Junova, Jan Korábečný, Kamil Kuča, Mária Kožurková
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3830 (2021)
A series of novel C4-C7-tethered biscoumarin derivatives (12a–e) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin 12d was found to be the most effective inhibitor of both acetyl
Externí odkaz:
https://doaj.org/article/8c388bb7284d4588979e48d7f965924d
Autor:
Eva Konkoľová, Monika Hudáčová, Slávka Hamuľaková, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Mária Kožurková
Publikováno v:
Molecules, Vol 26, Iss 4, p 1133 (2021)
A549 human lung carcinoma cell lines were treated with a series of new drugs with both tacrine and coumarin pharmacophores (derivatives 1a–2c) in order to test the compounds’ ability to inhibit both cancer cell growth and topoisomerase I and II a
Externí odkaz:
https://doaj.org/article/0af2efc10a534d30b4ed3b66d04503a4
Autor:
Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://doaj.org/article/6487d4fed0064893867020e3dda083eb
Autor:
Eva Konkolova, Kateřina Krejčová, Luděk Eyer, Jan Hodek, Michala Zgarbová, Andrea Fořtová, Michael Jirasek, Filip Teply, Paul E. Reyes-Gutierrez, Daniel Růžek, Jan Weber, Evzen Boura
Publikováno v:
Molecules, Vol 27, Iss 6, p 1894 (2022)
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +R
Externí odkaz:
https://doaj.org/article/2f4731e5b3e6434d9eb602e26cd5aaae
Autor:
Michal Hocek, Radek Pohl, Nemanja Milisavljevic, Luděk Eyer, Karel Čížek, Veronika Sýkorová, Lucia Veselovská, Pavel Svoboda, Jan Weber, Jaroslav Kozák, Radim Nencka, Jan Hodek, Evžen Bouřa, Daniel Růžek, Eva Konkolova
Publikováno v:
ACS Infectious Diseases
A series of 7-deazaadenine ribonucleosides bearing alkyl, alkenyl, alkynyl, aryl, or hetaryl groups at position 7 as well as their 5'-O-triphosphates and two types of monophosphate prodrugs (phosphoramidates and S-acylthioethanol esters) were prepare
Publikováno v:
Journal of Structural Biology
We report the crystal structure of the SARS-CoV-2 putative primase composed of the nsp7 and nsp8 proteins. We observed a dimer of dimers (2:2 nsp7-nsp8) in the crystallographic asymmetric unit. The structure revealed a fold with a helical core of the
Autor:
Jiří Böserle, Hubert Hřebabecký, Radim Nencka, Michal Šála, Eva Konkolova, Milan Dejmek, Evzen Boura
Publikováno v:
Antiviral Research
Remdesivir was shown to inhibit RNA-dependent RNA-polymerases (RdRp) from distinct viral families such as from Filoviridae (Ebola) and Coronaviridae (SARS-CoV, SARS-CoV-2, MERS). In this study, we tested the ability of remdesivir to inhibit RdRps fro
Autor:
Slavka Hamulakova, Katerina Babkova, Jana Kasparkova, Jan Korabecny, R. Jendzelovsky, Viktor Brabec, Eva Konkolova, Jana Plsikova, Kamil Kuca, Dana Kucerova, Peter Fedoročko, Ondrej Soukup, Ján Koval, Jana Vargová, Maria Kozurkova, Ján Rosocha, Jana Janockova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e54b25d849e3a39028ce551dd93a18