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Oviedomycin, an Unusual Angucyclinone Encoded by Genes of the Oleandomycin-Producer Streptomyces antibioticus ATCC11891

Autor: Carmen Mendez, Jürgen Rohr, Daniel W. Bearden, Michael Walla, William E Cotham, Jose A. Salas, Felipe Lombó, Eva Künzel, Alfredo F. Braña, Fredilyn Lipata

Publikováno v: Journal of Natural Products. 65:779-782

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84514c8f68c46a2e39926d04cb031222
https://doi.org/10.1021/np010555n

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Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics

Autor: Jürgen Rohr, Carsten Fischer, Axel Trefzer, Ulrich Girreser, Sigrid Stockert, Lucy Westrich, Eva Künzel, Andreas Bechthold

Publikováno v: Chemistry & Biology. 8(12):1239-1252

Background: The genetic engineering of antibiotic-producing Streptomyces strains is an approach that became a successful methodology in developing new natural polyketide derivatives. Glycosyltransferases are important biosynthetic enzymes that link s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4889396d9373646ebcbf406629f0fb2e

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The mtmVUC genes of the mithramycin gene cluster in Streptomycesargillaceus are involved in the biosynthesis of the sugar moieties

Autor: Lily L. Remsing, Eva Künzel, Felipe Lombó, J. Rohr, Alfredo F. Braña, Laura Prado, Carmen Méndez, Ana J. González, María José Azaustre Fernández, J.A. Salas

Publikováno v: Molecular Genetics and Genomics. 264:827-835

Mithramycin is a glycosylated aromatic polyketide produced by Streptomyces argillaceus, and is used as an antitumor drug. Three genes (mtmV, mtmU and mtmC) from the mithramycin gene cluster have been cloned, and characterized by DNA sequencing and by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d64eb1bb3cce2fa5c0f39a1386af9f
https://doi.org/10.1007/s004380000372

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The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster

Autor: Andreas Kirschning, Faust B, Jürgen Rohr, Gerald Dräger, Eva Künzel, D Hoffmeister, S. Domann, Axel Trefzer, Dan Bearden, Koji Ichinose, Carsten Fischer, Andreas Bechthold

Publikováno v: Chemistry & Biology. 7(11):821-831

Background: Streptomyces fradiae is the principal producer of urdamycin A. The antibiotic consists of a polyketide-derived aglycone, which is glycosylated with four sugar components, 2× D-olivose (first and last sugar of a C-glycosidically bound tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90eabcfe2c5c629d3d98f81d0de0ef46

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Inactivation of the urdGT2 Gene, Which Encodes a Glycosyltransferase Responsible for the C-Glycosyltransfer of Activated d-Olivose, Leads to Formation of the Novel Urdamycins I, J, and K

Autor: Daniel W. Bearden, Ulrike Weissbach, Lucia Westrich, Jürgen Rohr, Andreas Bechthold,‡ and, Gabriele Weitnauer, Carsten Oelkers, Bettina Faust, Eva Künzel

Publikováno v: Journal of the American Chemical Society. 121:11058-11062

A targeted search for glycosyltransferase (GT) encoding genes in the gene cluster of the urdamycin A producer Streptomyces fradiae Tu2717 resulted in the discovery of urdGT2, a GT encoding gene located approximately 7 kb downstream of the minimal pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d46d52e869090cc66b0403005c89423
https://doi.org/10.1021/ja9915347

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The Structure of Mithramycin Reinvestigated

Autor: Eva Künzel, Jürgen Rohr, Carmen Mendez, S.-E. Wohlert, Jose A. Salas, R Machinek

Publikováno v: Journal of Natural Products. 62:119-121

A reinvestigation of the structure of mithramycin, the principal product of Streptomyces argillaceus ATCC 12956, is reported. The structure elucidation was carried out with mithramycin decaacetate (4) using 2D NMR methods, including TOCSY, HMBC, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b40e98a52bfb92dbce0d75719dd828c
https://doi.org/10.1021/np980355k

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