Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eva J. Ge"'
Autor:
Rachel Leicher, Tom W. Muir, Bin Zhang, Matthew J. Reynolds, Xingcheng Lin, Eva J. Ge, Wen Jun Xie, Thomas Walz, Shixin Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Polycomb repressive complex 2 (PRC2) is a major epigenetic machinery that maintains transcriptionally silent heterochromatin in the nucleus and plays critical roles in embryonic development and oncogenesis. It is generally thought that P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe46b55357c81761a6fda40018de042
http://europepmc.org/articles/PMC7720148
http://europepmc.org/articles/PMC7720148
Autor:
Michael J. Petris, Michael L. Schilsky, Justin R. Cross, Q Ping Dou, Gina M. DeNicola, Ashley I. Bush, Peng Yuan, Roman S. Polishchuk, Sanjeev Gupta, Donita C. Brady, Stephen G. Kaler, Katherine J. Franz, Vishal M. Gohil, Nicholas K. Tonks, Vivek Mittal, Svetlana Lutsenko, Linda Van Aelst, Eva J Ge, Dan Xi, Martina Ralle, Angela Casini, Christopher J. Chang, Linda T. Vahdat, Paul A. Cobine
Publikováno v:
Nat Rev Cancer
Nature Reviews Cancer, vol 22, iss 2
Nature Reviews Cancer, vol 22, iss 2
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of different disciplines that can help translate ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5164f6aef86627fe77e70977f340f74
https://pubmed.ncbi.nlm.nih.gov/34764459
https://pubmed.ncbi.nlm.nih.gov/34764459
Autor:
Andrew R. D’Avino, Martin Filipovski, John D. Bagert, Hai T. Dao, Akshay Sankar, Nazar Mashtalir, Hengyuan Liu, Brittany C. Michel, Aaron J. Corin, Cigall Kadoch, Eva J. Ge, Geoffrey P. Dann, Tom W. Muir
Publikováno v:
Signal Transduction and Targeted Therapy
Chromatin landscape dictates remodeling Large, multicomponent molecular machines known as mammalian SWI/SNF (mSWI/SNF) chromatin-remodeling complexes play critical roles in governing the architecture of our genomes. These entities bind to chromatin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65599606b03203f3a91d5b4ff35c9a9c
https://pubmed.ncbi.nlm.nih.gov/34615852
https://pubmed.ncbi.nlm.nih.gov/34615852
Autor:
Kevin J. Bruemmer, Eva J Ge, Christopher J. Chang, Joel D.W. Toh, Diana A. Iovan, Dan He, Steven W. M. Crossley
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 41
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 41
The AlkB family of non-heme-Fe(II)/2-oxoglutarate(2OG)-dependent oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on RNA with release of formaldehyde (FA). Two major human AlkB family members, FTO and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a7b71bafd9f8555c54dc102ed6a4ff
https://europepmc.org/articles/PMC7568336/
https://europepmc.org/articles/PMC7568336/
Autor:
Christopher Chang, Diana Iovan, Dan He, Eva J. Ge, Kevin Bruemmer, Steven W. M. Crossley, Joel D.W. Toh
The AlkB family of non-heme-Fe(II)/2-oxoglutarate(2OG)-dependent oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on RNA with release of formaldehyde (FA). Two major human AlkB family members, FTO and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55f2b3bca2bdac62aab03b02390a32e6
https://doi.org/10.26434/chemrxiv.12816224
https://doi.org/10.26434/chemrxiv.12816224
Autor:
Eva J. Ge, Anne R. Gooding, Zachary Z. Brown, Richard D. Paucek, Thomas R. Cech, Tom W. Muir, Xueyin Wang
Publikováno v:
Nature structural & molecular biology
Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms requires biochemistry. Here we analyze interactions of reconstituted human PRC2 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4700848731d07989c5bf9e8e4990909
http://europepmc.org/articles/PMC5771497
http://europepmc.org/articles/PMC5771497
Autor:
Mark Esposito, Xiaoyang Su, David H. Perlman, Joshua D. Rabinowitz, Yael David, Michael Haugbro, Rob C. Oslund, Jung-Min Kee, Yibin Kang, Eva J. Ge, Tom W. Muir, Boyuan Wang
Publikováno v:
Nature chemical biology
Lower glycolysis involves a series of reversible reactions, which interconvert intermediates that also feed anabolic pathways. 3-phosphoglycerate (3-PG) is an abundant lower glycolytic intermediate that feeds serine biosynthesis via the enzyme phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2f8f053d7b7bfb5fa2ff7b1a67d115
https://doi.org/10.1038/nchembio.2453
https://doi.org/10.1038/nchembio.2453
Autor:
Tom W. Muir, Katharine L. Diehl, Krupa S. Jani, Eva J. Ge, C. David Allis, Daniel N. Weinberg
A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this "oncohistone" mutation acts by inhibiting the histone methyltransferase PRC2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b031144d160f4f9ede8774576c5227
https://europepmc.org/articles/PMC6825254/
https://europepmc.org/articles/PMC6825254/
Autor:
Matthew J. Reynolds, Shixin Liu, Xingcheng Lin, Rachel Leicher, Thomas Walz, Eva J. Ge, Tom W. Muir, Bin Zhang
Polycomb repressive complex 2 (PRC2) maintains transcriptionally silent heterochromatin by installing and spreading repressive histone methylation marks along nucleosome arrays. Despite extensive research, the mechanism by which PRC2 engages with chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191db31c6a2652cee1d17fd8d837898b
Publikováno v:
J Am Chem Soc
Polycomb Repressive Complex 2 (PRC2) catalyzes mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27me1-3) to control expression of genes important for differentiation and maintenance of cell identity. PRC2 activity is regulated by a numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cb7c5069b682f97596f197c89211da
https://pubmed.ncbi.nlm.nih.gov/31479253
https://pubmed.ncbi.nlm.nih.gov/31479253