Výsledky vyhledávání - "Eva I. Montero"

The trans Influence in the Modulation of Platinum Anticancer Agent Biology: The Effect of Nitrite Leaving Group on Aquation, Reactions with S-Nucleophiles and DNA Binding of Dinuclear and Trinuclear Compounds

Autor: Susan J. Berners-Price, Nicholas Farrell, Junyong Zhang, Joseph J. Moniodis, Eva I. Montero

Publikováno v: Chemistry - A European Journal. 16:9175-9185

To examine the effect of leaving group and trans influence on the geenral reactivity of polynuclear platinum antitumor agents we investigated substitution of the chloride leaving groups with nitrite ion, which forms strong bonds to Pt. It was of inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d115248a7104bbbb9292d2af53c61b
https://doi.org/10.1002/chem.200903578

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Antitumor and Cellular Pharmacological Properties of a Novel Platinum(IV) Complex:trans-[PtCl2(OH)2(Dimethylamine) (Isopropylamine)]

Autor: Carmen Navarro-Ranninger, Lloyd R. Kelland, F. E. Boxall, Eva I. Montero, Carlos Alonso, Miguel Fuertes, José M. Pérez

Publikováno v: Molecular Pharmacology. 63:933-944

The antitumor and cellular pharmacological properties of the trans-Pt(IV) complex, trans-[PtCl(2)(OH)(2)(dimethylamine)(isopropylamine)] (compound 2) has been evaluated in comparison with its corresponding trans-Pt(II) counterpart, trans-[PtCl(2)(dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d42614ac2086c401b881871035ef75
https://doi.org/10.1124/mol.63.4.933

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Apoptosis Induction and DNA Interstrand Cross-Link Formation by Cytotoxictrans-[PtCl2(NH(CH3)2)(NHCH(CH3)2)]: Cross-Linking between d(G) and Complementary d(C) within Oligonucleotide Duplexes

Autor: Miguel Fuertes, Annie Schwartz, Carlos Alonso, José M. Pérez, Eva I. Montero, Carmen Navarro-Ranninger, Jean Marc Malinge, Marc Leng

Publikováno v: ChemBioChem. 3:61-67

We have investigated the cytotoxic activity, the induction of apoptosis, and the interstrand cross-linking efficiency in the A2780cisR ovarian tumor cell line, after replacement of the two NH3 nonleaving groups in trans-[PtCl2(NH3)2] (trans-DDP) by d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::493f347c6d26e5995fca101aa1b88df9
https://doi.org/10.1002/1439-7633(20020104)3:1<61::aid-cbic61>3.0.co

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Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl2(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells

Autor: José M. Pérez, Miguel Fuertes, Adoración G. Quiroga, Carmen Navarro-Ranninger, Carlos Alonso, Eva I. Montero

Publikováno v: Metal-Based Drugs. 8:29-37

Trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] is a novel trans-platinum compound that shows cytotoxic activity in several cisplatin resistant cell lines. The aim of this paper was to analyse, by means of molecular cell biology techniques and total

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18c1535213f31e4fbe94cf4aa93d63b9
https://doi.org/10.1155/mbd.2001.29

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X-ray Structure of Cytotoxic trans-[PtCl2(dimethylamine)(isopropylamine)]: Interstrand Cross-Link Efficiency, DNA Sequence Specificity, and Inhibition of the B−Z Transition

Autor: José M. Pérez, Carmen Navarro-Ranninger, Carlos Alonso, Mercé Font-Bardia, Ana M. González, Xavier Solans, Eva I. Montero, Miguel Fuertes

Publikováno v: Journal of Medicinal Chemistry. 43:2411-2418

We report here the X-ray structure of cytotoxic trans-¿PtCl(2)(dimethylamine)(isopropylamine). This trans-platinum compound crystallizes in the monoclinic system, with Z = 8, in the spatial group C2/c with unit cell parameters a = 19.862(17) A, b =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e29e34789f7d7bac97742234f9a701
https://doi.org/10.1021/jm000925p

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Combined Effect of Platination and Intercalation upon DNA Binding of Novel Cytotoxic Pt−Bis(naphthalimide) Complexes

Autor: Miguel F. Brana, S. P. Robinson, Carmen Navarro-Ranninger, Carlos Alonso, Eva I. Montero, José M. Pérez, Isabel López-Solera

Publikováno v: Journal of Medicinal Chemistry. 42:5482-5486

The reaction of platinum salts with bis(naphthalimide), compound 1, yielded two Pt-bis(naphthalimide) complexes, compounds 2 and 3 which differ from each other in their leaving groups being 1,1-cyclobutane dicarboxylate or chloride, respectively. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb0f5374b162f7e301b8a0a7a6ca687
https://doi.org/10.1021/jm991099r

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Apoptosis induction and inhibition of H-ras overexpression by novel trans-[PtCl2(isopropylamine)(amine′)] complexes1This work was presented at the 8th International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, held in Oxford, UK, 28–31 March 1999.1

Autor: Covadonga Alonso, A.M. González, Amparo Alvarez-Valdés, Eva I. Montero, J.M. Pérez, Carmen Navarro-Ranninger

Publikováno v: Journal of Inorganic Biochemistry. 77:37-42

Hitherto, it has been generally accepted as a paradigm of the biochemical pharmacology of platinum antitumor drugs that a cis configuration of the leaving groups is necessary for antitumor activity of platinum compounds. However, it has been recently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe86cbe2d523e815687ce8942aa1fffa
https://doi.org/10.1016/s0162-0134(99)00143-9

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Synthesis and characterization of Pd(II) and Pt(II) complexes of -isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against -transformed cells

Autor: Carmen Navarro-Ranninger, Eva I. Montero, Adoración G. Quiroga, Douglas X. West, Carlos Alonso, José M. Pérez

Publikováno v: Journal of Inorganic Biochemistry. 75:293-301

Cytotoxicity tests in tumor cells sensitive to cis-DDP (HL-60, JURKAT, Hela and 3T3) and in tumor cells transformed by ras oncogenes and resistant to cis-DDP (Pam 212-ras) show that cyclometallated complexes 1a [Pd(p-is.TSCN-NHMe)]4, 2b [Pt(p-is.TSCN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5c8a5030dc2efb9f076945ffb8daaf
https://doi.org/10.1016/s0162-0134(99)00102-6

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Pre-association of polynuclear platinum anticancer agents on a protein, human serum albumin. Implications for drug design†

Autor: Yun Qu, Michael J. Oehlsen, Nicholas Farrell, John B. Mangrum, Eva I. Montero, Brad T. Benedetti

The interactions of polynuclear platinum complexes with human serum albumin were studied. The compounds examined were the "non-covalent" analogs of the trinuclear BBR3464 as well as the dinuclear spermidine-bridged compounds differing in only the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3555a58418c6b52644fb8eabd6634e8e
https://europepmc.org/articles/PMC2803314/

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Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes

Autor: Eva I, Montero, José M, Pérez, Annie, Schwartz, Miguel A, Fuertes, Jean M, Malinge, Carlos, Alonso, Marc, Leng, Carmen, Navarro-Ranninger

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2002, 3 (1), pp.61-7

International audience; We have investigated the cytotoxic activity, the induction of apoptosis, and the interstrand cross-linking efficiency in the A2780cisR ovarian tumor cell line, after replacement of the two NH3 nonleaving groups in trans-[PtCl2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bc0b2211ee9184fa1ca349d548b12009
https://hal.archives-ouvertes.fr/hal-02132063

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