Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eva Hrabeta‐Robinson"'
Autor:
Alison D. Tang, Colette Felton, Eva Hrabeta-Robinson, Roger Volden, Christopher Vollmers, Angela N. Brooks
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background RNA-seq has brought forth significant discoveries regarding aberrations in RNA processing, implicating these RNA variants in a variety of diseases. Aberrant splicing and single nucleotide variants (SNVs) in RNA have been demonstra
Externí odkaz:
https://doaj.org/article/e84f9fb100e24b9fa9603bd9e3275e12
Autor:
Alison D. Tang, Cameron M. Soulette, Marijke J. van Baren, Kevyn Hart, Eva Hrabeta-Robinson, Catherine J. Wu, Angela N. Brooks
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Long-read sequencing is useful in determining exon-connectivity of full-length mRNA isoforms. Here, by long-read nanopore sequencing, the authors report that intron retention is downregulated in SF3B1 mutant chronic lymphocytic leukemia cells than no
Externí odkaz:
https://doaj.org/article/6a806ecaedad4c65b48bc9c6561be042
Autor:
Changhui Mao, Christopher R Brown, Elena Falkovskaia, Shawfeng Dong, Eva Hrabeta‐Robinson, Lauren Wenger, Hinrich Boeger
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-12 (2010)
Abstract Gene transcription requires a sequence of promoter state transitions, including chromatin remodeling, assembly of the transcription machinery, and clearance of the promoter by RNA polymerase. The rate‐limiting steps in this sequence are re
Externí odkaz:
https://doaj.org/article/e7aa0b57e9b846b38242b8285094fb03
Autor:
Abolfazl Zargari, Gerrald A. Lodewijk, Najmeh Mashhadi, Nathan Cook, Celine W. Neudorf, Kimiasadat Araghbidikashani, Stefany Rubio, Eva Hrabeta-Robinson, Angela N. Brooks, Lindsay Hinck, S. Ali Shariati
Dynamics and non-genetic heterogeneity are two fundamental characteristics of basic processes of life such as cell division or differentiation. Time-lapse microscopy is the only method that can directly capture the dynamics and heterogeneity of funda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4899b780a1710cc680ced81fb1e4d1
https://doi.org/10.1101/2021.03.10.434806
https://doi.org/10.1101/2021.03.10.434806
Autor:
Roman E. Reggiardo, Sreelakshmi Velandi Maroli, Haley Halasz, Mehmet Ozen, Eva Hrabeta-Robinson, Amit Behera, Vikas Peddu, David Carrillo, Erin LaMontagne, Lila Whitehead, Eejung Kim, Shivani Malik, Jason Fernandes, Georgi Marinov, Eric Collisson, Angela Brooks, Utkan Demirci, Daniel H. Kim
Publikováno v:
Cell reports. 40(3)
RAS genes are the most frequently mutated oncogenes in cancer, yet the effects of oncogenic RAS signaling on the noncoding transcriptome remain unclear. We analyzed the transcriptomes of human airway and bronchial epithelial cells transformed with mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f22780d05c0a495f7d016be6541390
https://pubmed.ncbi.nlm.nih.gov/35858545
https://pubmed.ncbi.nlm.nih.gov/35858545
Autor:
Catherine J. Wu, Eva Hrabeta-Robinson, Cameron M. Soulette, Angela N. Brooks, Kevyn Hart, Alison D. Tang, Marijke J. van Baren
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the functional consequences of these mutations. We report nanopore sequencing of full-length cDNA from CLL samples wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b80d2c5d56a024699fa8e01cdebfd44
https://escholarship.org/uc/item/672470gc
https://escholarship.org/uc/item/672470gc
Autor:
Cameron M. Soulette, Angela N. Brooks, Maximillian Marin, Eva Hrabeta-Robinson, Austin M. Tang
U2AF1 S34F is one of the most recurrent splicing factor mutations in lung adenocarcinoma (ADC) and has been shown to cause transcriptome-wide pre-mRNA splicing alterations. While U2AF1 S34F-associated splicing alterations have been described, the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9ae4d127b0eaf33e3bffce54674a09
Autor:
Andrew J. MacRae, Robert J. Chalkley, Patricia P. Coltri, Melissa S. Jurica, Alma L. Burlingame, Eva Hrabeta-Robinson
Publikováno v:
RNA Biol
RNA biology, vol 16, iss 10
RNA biology, vol 16, iss 10
Structural models of multi-megadalton molecular complexes are appearing in increasing numbers, in large part because of technical advances in cryo-electron microscopy realized over the last decade. However, the inherent complexity of large biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2e7e1d8f494096c5bf2abbc4ac3ba6
https://doi.org/10.1101/448605
https://doi.org/10.1101/448605
Autor:
Eva Hrabeta-Robinson, Eric M. Phizicky, Aaron E. Cozen, Todd M. Lowe, Andrew D. Holmes, Erin Quartley
Publikováno v:
Nature Methods. 12:879-884
High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles of small RNAs, but RNAs containing modified nucleosides may escape detection when those modifications interfere with reverse transcription during RNA-seq library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db84c67d207eb045c88bc47fb4adeb61
https://doi.org/10.1038/nmeth.3508
https://doi.org/10.1038/nmeth.3508
Autor:
Melissa S. Jurica, Alma L. Burlingame, Andrew J. MacRae, Robert J. Chalkley, Megan Mayerle, Christine Guthrie, Eva Hrabeta-Robinson
Publikováno v:
RNA (New York, N.Y.), vol 24, iss 6
Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc95d561e214c4438bda2b737555dff5
https://pubmed.ncbi.nlm.nih.gov/29487104
https://pubmed.ncbi.nlm.nih.gov/29487104