Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Eva Hernández‐Illán"'
Autor:
Verónica Pablo-Fontecha, Eva Hernández-Illán, Andrea Reparaz, Elena Asensio, Jordi Morata, Raúl Tonda, Sara Lahoz, Carolina Parra, Juan José Lozano, Anabel García-Heredia, Alejandro Martínez-Roca, Sergi Beltran, Francesc Balaguer, Rodrigo Jover, Antoni Castells, Ramon Trullàs, Petar Podlesniy, Jordi Camps
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Somatic single-nucleotide variants (SNVs) occur every time a cell divides, appearing even in healthy tissues at low frequencies. These mutations may accumulate as neutral variants during aging, or eventually, promote the development of neopl
Externí odkaz:
https://doaj.org/article/99864895717e491da635fbdea8589d17
Autor:
Sebastià Franch-Expósito, Laia Bassaganyas, Maria Vila-Casadesús, Eva Hernández-Illán, Roger Esteban-Fabró, Marcos Díaz-Gay, Juan José Lozano, Antoni Castells, Josep Maria Llovet, Sergi Castellví-Bel, Jordi Camps
Publikováno v:
eLife, Vol 9 (2020)
Somatic copy number alterations (CNAs) are a hallmark of cancer, but their role in tumorigenesis and clinical relevance remain largely unclear. Here, we developed CNApp, a web-based tool that allows a comprehensive exploration of CNAs by using purity
Externí odkaz:
https://doaj.org/article/a0af249d134f486c9916e52fa1b83e3e
Autor:
Marcos Díaz-Gay, Maria Vila-Casadesús, Sebastià Franch-Expósito, Eva Hernández-Illán, Juan José Lozano, Sergi Castellví-Bel
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-6 (2018)
Abstract Background Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice. Up to now, several bioinformatic packages to address this
Externí odkaz:
https://doaj.org/article/19afd4437ed841bbbde3a658041cddcc
Autor:
Oscar Murcia, Míriam Juárez, María Rodríguez-Soler, Eva Hernández-Illán, Mar Giner-Calabuig, Miren Alustiza, Cecilia Egoavil, Adela Castillejo, Cristina Alenda, Víctor Barberá, Carolina Mangas-Sanjuan, Ana Yuste, Luís Bujanda, Joan Clofent, Montserrat Andreu, Antoni Castells, Xavier Llor, Pedro Zapater, Rodrigo Jover
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203051 (2018)
OBJECTIVE:The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to
Externí odkaz:
https://doaj.org/article/16decb5c201c4161a4fffd312ee4174c
Autor:
Miriam Juárez, Cecilia Egoavil, María Rodríguez-Soler, Eva Hernández-Illán, Carla Guarinos, Araceli García-Martínez, Cristina Alenda, Mar Giner-Calabuig, Oscar Murcia, Carolina Mangas, Artemio Payá, José R Aparicio, Francisco A Ruiz, Juan Martínez, Juan A Casellas, José L Soto, Pedro Zapater, Rodrigo Jover
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184937 (2017)
High-risk features of colonic polyps are based on size, number, and pathologic characteristics. Surveillance colonoscopy is often recommended according to these findings. This study aimed to determine whether the molecular characteristics of polyps m
Externí odkaz:
https://doaj.org/article/dbd27c08b506450da8af285c53a72c31
Autor:
Ajay Goel, C. Richard Boland, Antoni Castells, Xavier Llor, Montserrat Andreu, Francesc Balaguer, Cristina Alenda, Estefania Rojas, Eva Hernández-Illán, Miriam Juárez, Lucia Perez-Carbonell, Cecilia Egoavil, Rodrigo Jover, Oscar Murcia
Purpose: A recent study reported that 5-fluorouracil (5-FU)-based chemotherapy is less effective in treating patients with advanced colorectal cancer demonstrating hypermethylation of the TFAP2E gene. The aim of our study was to confirm and validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dbea501a83cf50f8b529096f5ce5b8
https://doi.org/10.1158/1078-0432.c.6525716.v1
https://doi.org/10.1158/1078-0432.c.6525716.v1
Autor:
Ajay Goel, C. Richard Boland, Antoni Castells, Xavier Llor, Montserrat Andreu, Francesc Balaguer, Cristina Alenda, Estefania Rojas, Eva Hernández-Illán, Miriam Juárez, Lucia Perez-Carbonell, Cecilia Egoavil, Rodrigo Jover, Oscar Murcia
Supplementary Figure 4. Epicolon I. Overall Survival Stage IV Patients: TFAP2E IHC Expression. Disease Free Survival Stage II and III Patients: TFAP2E IHC Expression. (A) Overall survival of patients with stage IV disease, according to TFAP2E express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c18a5718bed4aba2394cfb10756257d
https://doi.org/10.1158/1078-0432.22464425
https://doi.org/10.1158/1078-0432.22464425
Autor:
Ajay Goel, C. Richard Boland, Antoni Castells, Xavier Llor, Montserrat Andreu, Francesc Balaguer, Cristina Alenda, Estefania Rojas, Eva Hernández-Illán, Miriam Juárez, Lucia Perez-Carbonell, Cecilia Egoavil, Rodrigo Jover, Oscar Murcia
Supplementary Figure 3. Correlation between TFAP2E intron 3 methylation and IHC expression. When methylation was analysed as a continuous variable using linear regression analysis, we observed a trend towards negative correlation with IHC protein exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401cff78e7eb3cedf405838fb60cafba
https://doi.org/10.1158/1078-0432.22464428
https://doi.org/10.1158/1078-0432.22464428
Autor:
Ajay Goel, C. Richard Boland, Antoni Castells, Xavier Llor, Montserrat Andreu, Francesc Balaguer, Cristina Alenda, Estefania Rojas, Eva Hernández-Illán, Miriam Juárez, Lucia Perez-Carbonell, Cecilia Egoavil, Rodrigo Jover, Oscar Murcia
Supplementary Figure 1. Schematic representation of TFAP2E gene. The gene encoding transcription factor AP-2 epsilon (TFAP2E) is located on chromosome 1p34. In the schematic overview, exons are represented by blue boxes and introns with blue lines. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b4db557cc7027a8164e014566fe1b8
https://doi.org/10.1158/1078-0432.22464422
https://doi.org/10.1158/1078-0432.22464422
Autor:
Ajay Goel, C. Richard Boland, Antoni Castells, Xavier Llor, Montserrat Andreu, Francesc Balaguer, Cristina Alenda, Estefania Rojas, Eva Hernández-Illán, Miriam Juárez, Lucia Perez-Carbonell, Cecilia Egoavil, Rodrigo Jover, Oscar Murcia
Supplementary Figure 2. Methylation analysis of TFAP2E CpG islands in CRC tissues. Calculation of cutoff value of TFAP2E Intron 3 methylation. Results comparing methylation of the TFAP2E CpG1 (Promoter/Exon 1) and CpG2 (Intron 3) in CRC tissues (N=50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a934f2e61084649743df358d5f1f4f3b
https://doi.org/10.1158/1078-0432.22464434
https://doi.org/10.1158/1078-0432.22464434