IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival.

Autor: Selim Nur, Florian Sparber, Christina Lemberg, Eva Guiducci, Tiziano A Schweizer, Pascale Zwicky, Burkhard Becher, Salomé LeibundGut-Landmann

Publikováno v: PLoS Pathogens, Vol 15, Iss 12, p e1008115 (2019)

The opportunistic fungal pathogen Candida albicans can cause invasive infections in susceptible hosts and the innate immune system, in particular myeloid cell-mediated immunity, is critical for rapid immune protection and host survival during systemi

Externí odkaz: https://doaj.org/article/9276a4079b104e98ba2352773a72ed30

Identification of Candida albicans regulatory genes governing mucosal infection

Autor: Andreas Rosenwald, Elena Hartmann, J. Christian Pérez, Marie-Therese Eckstein, Juliane Meir, Salomé LeibundGut-Landmann, Florian R. Kirchner, Eva Guiducci

Publikováno v: Cellular microbiology. 20(8)

The fungus Candida albicans thrives on a variety of human mucosae, yet the fungal determinants that contribute to fitness on these surfaces remain underexplored. Here, by screening a collection of C. albicans deletion strains in a mouse model of oral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec6f09129eeb2288bc42d7c4fc7fdc7
https://pubmed.ncbi.nlm.nih.gov/29575428

The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity

Autor: Florian Sparber, Marie-Elisabeth Bougnoux, Natacha Sertour, K. Trautwein-Weidner, U. Hetzel, Norman Pavelka, F. A. Schönherr, G. T. T. Le, A. Gladiator, Salomé LeibundGut-Landmann, C. F. Corti, Eva Guiducci, Florian R. Kirchner, Christophe d'Enfert

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2017, 75, Advance online publication. ⟨10.1038/mi.2017.2⟩
Mucosal Immunology, 2017, 75 (5), Advance online publication. ⟨10.1038/mi.2017.2⟩
Mucosal Immunology, Nature Pub. Group, 2017, 75 (5), Advance online publication. ⟨10.1038/mi.2017.2⟩

International audience; The host immune status is critical for preventing opportunistic infections with Candida albicans. Whether the natural fungal diversity that exists between C. albicans isolates also influences disease development remains unclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1123d567782e0933d7b969a43a1d2597
https://hal-pasteur.archives-ouvertes.fr/pasteur-01518278/file/mi20172a.pdf

Mast cells are dispensable in a genetic mouse model of chronic dermatitis

Autor: Eva Guiducci, Michael R. Meyer, Thorsten B. Feyerabend, Jitka Sulcova, Hans Reimer Rodewald, Sabine Werner

Publikováno v: The American journal of pathology. 185(6)

Chronic inflammatory skin diseases, such as atopic dermatitis, affect a large percentage of the population, but the role of different immune cells in the pathogenesis of these disorders is largely unknown. Recently, we found that mice lacking fibrobl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63380bf95c33c9b454d6bad5d6e9cc83
https://pubmed.ncbi.nlm.nih.gov/25843682