Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Eva Gottfried"'
Autor:
Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby, Marina Kreutz
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 135-150.e9 (2019)
Summary: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival
Externí odkaz:
https://doaj.org/article/ca9683bbded745c68d1cf4f71ab912e4
Autor:
Kathrin Renner, Anton Seilbeck, Nathalie Kauer, Ines Ugele, Peter J. Siska, Christina Brummer, Christina Bruss, Sonja-Maria Decking, Matthias Fante, Astrid Schmidt, Kathrin Hammon, Katrin Singer, Sebastian Klobuch, Simone Thomas, Eva Gottfried, Katrin Peter, Marina Kreutz
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The accelerated metabolism of tumor cells, inevitable for maintaining high proliferation rates, is an emerging target for tumor therapy. Increased glucose and lipid metabolism as well as mitochondrial activity have been shown in solid tumors but also
Externí odkaz:
https://doaj.org/article/2a068e5a9f344f869bc511d67dced0cf
Autor:
Ines Ugele, Zugey Elizabeth Cárdenas-Conejo, Kathrin Hammon, Monika Wehrstein, Christina Bruss, Katrin Peter, Katrin Singer, Eva Gottfried, Jakob Boesch, Peter Oefner, Katja Dettmer, Kathrin Renner, Marina Kreutz
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 742 (2019)
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiat
Externí odkaz:
https://doaj.org/article/71614b3a027c46b482c42d297ff17421
Autor:
Eva Gottfried, Sven A Lang, Kathrin Renner, Anja Bosserhoff, Wolfram Gronwald, Michael Rehli, Sabine Einhell, Isabel Gedig, Katrin Singer, Anton Seilbeck, Andreas Mackensen, Oliver Grauer, Peter Hau, Katja Dettmer, Reinhard Andreesen, Peter J Oefner, Marina Kreutz
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66987 (2013)
Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac. Diclofenac si
Externí odkaz:
https://doaj.org/article/64919e4e9d61407e8bc01ae34269ec63
Autor:
Oliver Stoeltzing, Edward K. Geissler, Hans J. Schlitt, Marina Kreutz, Eva Gottfried, Christina Hackl, Sven A. Lang, Christian Moser, Akira Mori
Supplementary Data from Up-Regulation of Krüppel-Like Factor 5 in Pancreatic Cancer Is Promoted by Interleukin-1β Signaling and Hypoxia-Inducible Factor-1α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6053cc9676ae2af1b833e0685939aef6
https://doi.org/10.1158/1541-7786.22518684
https://doi.org/10.1158/1541-7786.22518684
Autor:
Eva Gottfried
Landwirtschaft geht uns alle an!Mit immer ertragreicheren Sorten, modernen Düngemitteln und potenten Pestiziden haben wir jahrelang eine intensivierte Landwirtschaft auf Kosten der Natur vorangetrieben. Nun schielen immer mehr Landwirte auf naturnah
Autor:
Eva Gottfried
Publikováno v:
Biologie in unserer Zeit. 45:90-96
Ein Tumor wurde fruher als eine Masse mutierter Zellen betrachtet, die durch ubermasige Zellproliferation und verhinderten Zelltod entsteht. Inzwischen ist allgemein anerkannt, dass nicht nur Tumorzellen alleine, sondern auch ihre Nachbarzellen eine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f607c7f83fba04b256ae33fb30aedd
https://doi.org/10.1002/biuz.201510560
https://doi.org/10.1002/biuz.201510560
Autor:
Hannelore Rücker, Tobias P. Dick, Sabine Amslinger, Nafisah Al-Rifai, Lidia Brodziak-Jarosz, Clarissa Gerhäuser, Anne Rascle, Eva Gottfried
Publikováno v:
Organic & Biomolecular Chemistry. 13:3040-3047
Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef60178da4b9232b286228cb43d4614
https://doi.org/10.1039/c4ob02301c
https://doi.org/10.1039/c4ob02301c
Publikováno v:
Seminars in Cancer Biology. 22:335-341
About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of cancer cell. In the meantime it has become clear, that the altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922e94cdd0d9e9092b1e2cdb1f2e5cc7
https://doi.org/10.1016/j.semcancer.2012.02.009
https://doi.org/10.1016/j.semcancer.2012.02.009
Autor:
Marina Kreutz, Katrin Stadler, Peter Hau, Peter J. Oefner, Bernhard Neumann, Sridhar Reddy Chirasani, Eva Gottfried, Jochen Hochrein, Wolfram Gronwald, Ulrich Bogdahn, Petra Leukel, Oliver Grauer
Publikováno v:
International Journal of Cancer. 132:843-853
Lactate formation in highly proliferative tumors such as malignant gliomas is associated with poor survival and contributes to the suppression of local immunity. Here, we report that diclofenac used at nontoxic concentrations significantly decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd84f509a0c305163b0a96d7fc1459cf
https://doi.org/10.1002/ijc.27712
https://doi.org/10.1002/ijc.27712