B cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia

Autor: Andrea N. Mazzarello, Eva Gentner-Göbel, Marcus Dühren-von Minden, Tatyana N. Tarasenko, Antonella Nicolò, Gerardo Ferrer, Stefano Vergani, Yun Liu, Davide Bagnara, Kanti R. Rai, Jan A. Burger, Peter J. McGuire, Palash C. Maity, Hassan Jumaa, Nicholas Chiorazzi

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)

In chronic lymphocytic leukemia (CLL), the B cell receptor (BCR) plays a critical role in disease development and progression, as indicated by the therapeutic efficacy of drugs blocking BCR signaling. However, the mechanism(s) underlying BCR responsi

Externí odkaz: https://doaj.org/article/66a5d21ed217411b9bb0675bdc0e82e4

IGLV3-21∗01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Autor: Hassan Jumaa, Wilma G. M. Kroes, Henrik E. Mei, Palash Chandra Maity, Daniela Steinbrecher, Christian E. Busse, Tamara Bittolo, Ruben A.L. de Groen, Kostas Stamatopoulos, Konstantia Kotta, Rob S Barendse, Nicholas Chiorazzi, Marvyn T. Koning, Valerio Renna, Antonella Nicolò, Eugen Tausch, Eva Gentner-Göbel, Marc Young, Stephan Stilgenbauer, Cornelis A.M. van Bergen, Massimo Degano, Giovanni Del Poeta, Joost S.P. Vermaat, Paolo Ghia, J Tom van Wezel, Antonella Zucchetto, Sebastiaan F Somers, Mayas Bilal, Katharina Imkeller, Valter Gattei, Hendrik Veelken, Moumita Datta, Hedda Wardemann, Christof Schneider, Riccardo Bomben, Tamam Bakchoul, Andrea Nicola Mazzarello, Axel Schulz

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences, 117(8), 4320-4327. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences

Significance CLL is characterized by autonomous B cell receptor (BCR) signaling. CLL subsets are empirically defined by sequence similarities of the BCR heavy chain. However, in the unfavorable subset 2, an acquired mutation (termed R110) in the ligh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d58aad7f4ec5e2f0632d1dda8f40ce