CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in human

Autor: Sara Menegatti, Bethany Potts, Roberto Paredes, Eva Garcia-Alegria, Syed Murtuza Baker, Valerie Kouskoff

Publikováno v: iScience, Vol 26, Iss 9, Pp 107583- (2023)

Summary: During embryonic development, all blood progenitors are initially generated from endothelial cells that acquire a hemogenic potential. Blood progenitors emerge through an endothelial-to-hematopoietic transition regulated by the transcription

Externí odkaz: https://doaj.org/article/6bb48522d23c4237a23329e5cbe76b45

In vitro differentiation of human embryonic stem cells to hemogenic endothelium and blood progenitors via embryoid body formation

Autor: Eva Garcia-Alegria, Bethany Potts, Sara Menegatti, Valerie Kouskoff

Publikováno v: STAR Protocols, Vol 2, Iss 1, Pp 100367- (2021)

Summary: Little is known about the emergence of blood progenitors during human embryogenesis due to ethical reasons and restricted embryo access. The use of human embryonic stem cells (hESCs) as a model system offers unique opportunities to dissect h

Externí odkaz: https://doaj.org/article/e3c92cc63ea845ef995745c4ff32fbdb

In vitro differentiation of human embryonic stem cells to hemogenic endothelium and blood progenitors via embryoid body formation

Autor: Sara Menegatti, Valerie Kouskoff, Eva Garcia-Alegria, Bethany Potts

Publikováno v: Garcia-Alegria, E, Potts, B, Menegatti, S & Kouskoff, V 2021, ' In vitro differentiation of human embryonic stem cells to hemogenic endothelium and blood progenitors via embryoid body formation ', STAR protocols, vol. 2, no. 1, 100367 . https://doi.org/10.1016/j.xpro.2021.100367
STAR Protocols
STAR Protocols, Vol 2, Iss 1, Pp 100367-(2021)

Summary Little is known about the emergence of blood progenitors during human embryogenesis due to ethical reasons and restricted embryo access. The use of human embryonic stem cells (hESCs) as a model system offers unique opportunities to dissect hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5258277ea4a53b269ca866f193f06996
https://pure.manchester.ac.uk/ws/files/195424294/1_s2.0_S2666166721000745_main.pdf

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

Autor: Maria del Carmen Lafita-Navarro, Javier León, Miguel Lafarga, Olga Tapia, Eva Garcia-Alegria, Judit Liaño-Pons, Maria T. Berciano, Rosa M. Blanco, Lucía García-Gutiérrez, Jorge Mata-Garrido

Publikováno v: Oncotarget
Oncotarget. 2016 Aug 31
Lafita-Navarro, M D C, Blanco, R, Mata-Garrido, J, Liaño-Pons, J, Tapia, O, García-Gutiérrez, L, García-Alegría, E, Berciano, M T, Lafarga, M & León, J 2016, ' MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis ', Oncotarget, vol. 7, no. 43, pp. 69536-69548 . https://doi.org/10.18632/oncotarget.11766
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

MXD1 is a protein that interacts with MAX, to form a repressive transcription factor. MXD1-MAX binds E-boxes. MXD1-MAX antagonizes the transcriptional activity of the MYC oncoprotein in most models. It has been reported that MYC overexpression leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e12896454ac5545fac978ba8c41e44
https://doi.org/10.18632/oncotarget.11766

Corrigendum: Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage

Autor: Eva, Garcia-Alegria, Maria, Iliut, Monika, Stefanska, Claudio, Silva, Sebastian, Heeg, Susan J, Kimber, Valerie, Kouskoff, Georges, Lacaud, Aravind, Vijayaraghavan, Kiran, Batta

Publikováno v: Scientific Reports

Pluripotent stem cells represent a promising source of differentiated tissue-specific stem and multipotent progenitor cells for regenerative medicine and drug testing. The realisation of this potential relies on the establishment of robust and reprod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddaaabed30c1e21ecd6918a0fed53741
https://pubmed.ncbi.nlm.nih.gov/27197878