Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eva Göb"'
Autor:
Jana Link, Monika Leubner, Johannes Schmitt, Eva Göb, Ricardo Benavente, Kuan-Teh Jeang, Rener Xu, Manfred Alsheimer
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004099 (2014)
LINC complexes are evolutionarily conserved nuclear envelope bridges, composed of SUN (Sad-1/UNC-84) and KASH (Klarsicht/ANC-1/Syne/homology) domain proteins. They are crucial for nuclear positioning and nuclear shape determination, and also mediate
Externí odkaz:
https://doaj.org/article/03be2a28102e44d3a9ab7b1620ecc036
Autor:
Jana Link, Daniel Jahn, Johannes Schmitt, Eva Göb, Johannes Baar, Sagrario Ortega, Ricardo Benavente, Manfred Alsheimer
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003261 (2013)
The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape. In the past, a number of severe human disorders have been identified to
Externí odkaz:
https://doaj.org/article/d13752f951f142cdb898c1201f37af75
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12072 (2010)
BACKGROUND: LINC complexes are nuclear envelope bridging protein structures formed by interaction of SUN and KASH proteins. They physically connect the nucleus with the peripheral cytoskeleton and are critically involved in a variety of dynamic proce
Externí odkaz:
https://doaj.org/article/83806974dcf74cd286c305861683e206
Autor:
Eva Göb, Kerstin Göbel, Stephan Reymann, Marc Brede, Christian Geis, Bernhard Nieswandt, Christoph Kleinschnitz, Guido Stoll, Sven G. Meuth, Peter Kraft, György A. Homola, Ina Thielmann, Laszlo Solymosi, Michael K. Schuhmann, Friederike Langhauser
Publikováno v:
Annals of Neurology. 77:784-803
Objective Recent evidence suggests that ischemic stroke is a thromboinflammatory disease. Plasma kallikrein (PK) cleaves high–molecular-weight kininogen to release bradykinin (BK) and is a key constituent of the proinflammatory contact-kinin system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a03a114cd0bc45cd3d61e0bc454c435
https://doi.org/10.1002/ana.24380
https://doi.org/10.1002/ana.24380
Autor:
Jonas Leinweber, Friederike Langhauser, Stefan Bittner, Peter Kraft, M. Gelderblom, Kristina Lorenz, Tim Magnus, Michael K. Schuhmann, Christoph Kleinschnitz, Sven G. Meuth, Heinz Wiendl, Eva Göb
Publikováno v:
Stroke. 45:1799-1806
Background and Purpose— T lymphocytes have recently been identified as key mediators of tissue damage in ischemic stroke. The interaction between very late antigen-4 (VLA-4) and vascular adhesion molecule-1 is crucial for the transvascular egress o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d8370312cb1d3eb74b5e40a1f99d7a
https://doi.org/10.1161/strokeaha.114.005000
https://doi.org/10.1161/strokeaha.114.005000
Autor:
Tobias Schwarz, Marc Brede, Eva Göb, Nadine Heydenreich, Peter Kraft, Sven G. Meuth, Christoph Kleinschnitz
Publikováno v:
Experimental Neurology, 247, 80-90. Elsevier Science
Blood–brain-barrier (BBB) disruption, inflammation and thrombosis are important steps in the pathophysiology of acute ischemic stroke but are still inaccessible to therapeutic interventions. Rolipram specifically inhibits the enzyme phosphodiestera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be5a202c23b21c0844e123b87f25708
https://doi.org/10.1016/j.expneurol.2013.03.026
https://doi.org/10.1016/j.expneurol.2013.03.026
Autor:
Sven G. Meuth, Peter Kraft, Eva Göb, Martin Bendszus, Kerstin Göbel, Peter M. Jakob, Xavier Helluy, Marc Brede, Keith R. McCrae, Christoph Kleinschnitz, Bernhard Nieswandt, Christian Geis, Friederike Langhauser, Joachim P. Schmitt, Mirko Pham, Guido Stoll
Publikováno v:
Blood, 120(19), 4082-4092. The American Society of Hematology
Thrombosis and inflammation are hallmarks of ischemic stroke still unamenable to therapeutic interventions. High-molecular-weight kininogen (KNG) is a central constituent of the contact-kinin system which represents an interface between thrombotic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bc51682ce7dd82dc07663f67896a34
https://doi.org/10.1182/blood-2012-06-440057
https://doi.org/10.1182/blood-2012-06-440057
Autor:
Marc Brede, Peter Kraft, Christoph Kleinschnitz, Guido Stoll, Csanad Varallyay, Christiane Albert-Weissenberger, Marc W. Nolte, Eva Göb, Gerhard Dickneite, Nadine Heydenreich, Marion Hofmeister, Bernhard Nieswandt, Sven G. Meuth, Friederike Langhauser, Kerstin Göbel
Publikováno v:
Stroke, 43(9), 2457-2467. LIPPINCOTT WILLIAMS & WILKINS
Background and Purpose— Inflammation and thrombosis are pathophysiological hallmarks of ischemic stroke still unamenable to therapeutic interventions. The contact-kinin system represents an interface between inflammatory and thrombotic circuits and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d361da2151566bca525a7463b3ecad56
https://doi.org/10.1161/STROKEAHA.112.660340
https://doi.org/10.1161/STROKEAHA.112.660340
Autor:
David W. Howells, Carlijn R. Hooijmans, Sarah S. J. Rewell, Kim A. Radermacher, Eva Göb, Harald H.H.W. Schmidt, Merel Ritskes-Hoitinga, Friederike Langhauser, Pamela W. M. Kleikers, Christoph Kleinschnitz
Publikováno v:
Scientific Reports, 5
Scientific Reports
Scientific Reports, 5:13428. Nature Publishing Group
Scientific Reports
Scientific Reports, 5:13428. Nature Publishing Group
Contains fulltext : 154923.pdf (Publisher’s version ) (Open Access) Biomedical research suffers from a dramatically poor translational success. For example, in ischemic stroke, a condition with a high medical need, over a thousand experimental drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2231261adcbca7eda48e5983eb7e62
Autor:
Friederike Ufer, Eva Göb, Alexander M. Herrmann, Tim Magnus, Christian Gerloff, Christoph Kleinschnitz, Markus Glatzel, Priyadharshini Arunachalam, Christian Bernreuther, Sven G. Meuth, Stefan Bittner, Nico Melzer, Manuel A. Friese, Mathias Gelderblom, Gordon Hicking, Benjamin Schattling
Publikováno v:
Stroke. 45(11)
Background and Purpose— Brain injury during stroke results in oxidative stress and the release of factors that include extracellular Ca 2+ , hydrogen peroxide, adenosine diphosphate ribose, and nicotinic acid adenine dinucleotide phosphate. These a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124993fe54c73d9f427e232e49da5e9d
https://pubmed.ncbi.nlm.nih.gov/25236871
https://pubmed.ncbi.nlm.nih.gov/25236871