Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Eva G, Rakasz"'
Autor:
Brandon C. Rosen, Kaitlin Sawatzki, Michael J. Ricciardi, Elise Smith, Inah Golez, Jack T. Mauter, Núria Pedreño-López, Aaron Yrizarry-Medina, Kim L. Weisgrau, Logan J. Vosler, Thomas B. Voigt, Johan J. Louw, Jennifer Tisoncik-Go, Leanne S. Whitmore, Christakis Panayiotou, Noor Ghosh, Jessica R. Furlott, Christopher L. Parks, Ronald C. Desrosiers, Jeffrey D. Lifson, Eva G. Rakasz, David I. Watkins, Michael Gale
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSpontaneous control of chronic-phase HIV/SIV viremia is often associated with the expression of specific MHC class I allotypes. HIV/SIV-specific CD8+ cytotoxic T lymphocytes (CTLs) restricted by these MHC class I allotypes appear to be cr
Externí odkaz:
https://doaj.org/article/a278c58415384153962a8239ac4c5dc6
Autor:
Fangzhu Zhao, Zachary T. Berndsen, Nuria Pedreño-Lopez, Alison Burns, Joel D. Allen, Shawn Barman, Wen-Hsin Lee, Srirupa Chakraborty, Sandrasegaram Gnanakaran, Leigh M. Sewall, Gabriel Ozorowski, Oliver Limbo, Ge Song, Peter Yong, Sean Callaghan, Jessica Coppola, Kim L. Weisgrau, Jeffrey D. Lifson, Rebecca Nedellec, Thomas B. Voigt, Fernanda Laurino, Johan Louw, Brandon C. Rosen, Michael Ricciardi, Max Crispin, Ronald C. Desrosiers, Eva G. Rakasz, David I. Watkins, Raiees Andrabi, Andrew B. Ward, Dennis R. Burton, Devin Sok
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection i
Externí odkaz:
https://doaj.org/article/2aa7798e6f944e178232a7a70fe98e0c
Autor:
Meredith E. Davis-Gardner, Jesse A. Weber, Jun Xie, Katja Pekrun, Eric A. Alexander, Kim L. Weisgrau, Jessica R. Furlott, Eva G. Rakasz, Mark A. Kay, Guangping Gao, Michael Farzan, Matthew R. Gardner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionUse of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular admi
Externí odkaz:
https://doaj.org/article/00463782da80486d88a3fbab8e5a811b
Autor:
Mary S. Pampusch, Emily N. Sevcik, Zoe E. Quinn, Brianna C. Davey, James M. Berg, Ian Gorrell-Brown, Hadia M. Abdelaal, Eva G. Rakasz, Aaron Rendahl, Pamela J. Skinner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
During chronic HIV and SIV infections, the majority of viral replication occurs within lymphoid follicles. In a pilot study, infusion of SIV-specific CD4-MBL-CAR-T cells expressing the follicular homing receptor, CXCR5, led to follicular localization
Externí odkaz:
https://doaj.org/article/bcf05bd5002b465cbbd4d44dfa79b0f9
Autor:
Brianna C. Davey, Mary S. Pampusch, Emily K. Cartwright, Hadia M. Abdelaal, Eva G. Rakasz, Aaron Rendahl, Edward A. Berger, Pamela J. Skinner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T cells expressing a simian immunodeficiency (SIV)-specific chimeric antigen receptor (CAR) and the follicular homing molecule, CXCR5, were infused into antiretroviral therapy (ART) suppressed, SIV-infected rhesus macaques to assess their ability to
Externí odkaz:
https://doaj.org/article/dcd9f049ddbd4f4ea011577c4e6dd6e5
Autor:
Nuria Pedreño-Lopez, Michael J. Ricciardi, Brandon C. Rosen, Ge Song, Raiees Andrabi, Dennis R. Burton, Eva G. Rakasz, David I. Watkins
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 781-790 (2020)
Simian immunodeficiency virus (SIV) infection of Indian rhesus macaques (RMs) is one of the best-characterized animal models for human immunodeficiency virus (HIV) infection. Monoclonal antibodies (mAbs) have shown promise for prevention and treatmen
Externí odkaz:
https://doaj.org/article/5a70f718f1e1409096c9cf4d050ebc8c
Autor:
Nuria Pedreño-Lopez, Christine M. Dang, Brandon C. Rosen, Michael J. Ricciardi, Varian K. Bailey, Martin J. Gutman, Lucas Gonzalez-Nieto, Matthias G. Pauthner, Khoa Le, Ge Song, Raiees Andrabi, Kim L. Weisgrau, Nicholas Pomplun, José M. Martinez-Navio, Sebastian P. Fuchs, Jens Wrammert, Eva G. Rakasz, Jeffrey D. Lifson, Mauricio A. Martins, Dennis R. Burton, David I. Watkins, Diogo M. Magnani
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 225-237 (2020)
Structural characterization of the HIV-1 Envelope (Env) glycoprotein has facilitated the development of Env probes to isolate HIV-specific monoclonal antibodies (mAbs). However, preclinical studies have largely evaluated these virus-specific mAbs aga
Externí odkaz:
https://doaj.org/article/583e2f5e1bdc4c94b11792ddc7103b3a
Autor:
Sebastian P. Fuchs, José M. Martinez-Navio, Eva G. Rakasz, Guangping Gao, Ronald C. Desrosiers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 94-102 (2020)
A number of publications have described the use of adeno-associated virus (AAV) for the delivery of anti-HIV and anti-simian immunodeficiency virus (SIV) monoclonal antibodies (mAbs) to rhesus monkeys. Anti-drug antibodies (ADAs) have been frequently
Externí odkaz:
https://doaj.org/article/3970fe89b2a04b72b37ac27be8e57d9a
Autor:
Mary S. Pampusch, Kumudhini Preethi Haran, Geoffrey T. Hart, Eva G. Rakasz, Aaron K. Rendahl, Edward A. Berger, Elizabeth Connick, Pamela J. Skinner
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 1-10 (2020)
Chimeric antigen receptor (CAR)-T cells show great promise in treating cancers and viral infections. However, most protocols developed to expand T cells require relatively long periods of time in culture, potentially leading to progression toward pop
Externí odkaz:
https://doaj.org/article/0a8ea1a36b2a406280e6a375ee032b74
Autor:
Mary S Pampusch, Hadia M Abdelaal, Emily K Cartwright, Jhomary S Molden, Brianna C Davey, Jordan D Sauve, Emily N Sevcik, Aaron K Rendahl, Eva G Rakasz, Elizabeth Connick, Edward A Berger, Pamela J Skinner
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009831 (2022)
During chronic human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection prior to AIDS progression, the vast majority of viral replication is concentrated within B cell follicles of secondary lymphoid tissues. We investigate
Externí odkaz:
https://doaj.org/article/ec02b79848574b81a11bd4e2ead3af63