Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Eva Estébanez‐Perpiñá"'
Autor:
Lisa M. Sevilla, Alba Jiménez-Panizo, Andrea Alegre-Martí, Eva Estébanez-Perpiñá, Carme Caelles, Paloma Pérez
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10049 (2021)
Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types to modulate tissue homeostasis throughout life. Also, synthetic GC derivatives (pharmacological GCs) constitute the first-line treatment in many chronic inf
Externí odkaz:
https://doaj.org/article/577e6aa429154e5cbde6301eda4ad9f0
Autor:
Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta Vilaseca, Marta Taulès, Adriaan B. Houtsmuller, Martin E. van Royen, Frank Claessens, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface t
Externí odkaz:
https://doaj.org/article/e16dab5dd1bd4ba28ae91fea89b288b4
Autor:
Sara B Estruch, Víctor Buzón, Laia R Carbó, Lenka Schorova, Jens Lüders, Eva Estébanez-Perpiñá
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37963 (2012)
Nuclear orphan receptor TLX (NR2E1) functions primarily as a transcriptional repressor and its pivotal role in brain development, glioblastoma, mental retardation and retinopathologies make it an attractive drug target. TLX is expressed in the neural
Externí odkaz:
https://doaj.org/article/3e1099b6169e46298a3ccfbe85417fb3
Autor:
Alba Jiménez-Panizo, Andrea Alegre-Martí, Theophilus T Tettey, Gregory Fettweis, Montserrat Abella, Rosa Antón, Thomas A Johnson, Sohyoung Kim, R Louis Schiltz, Israel Núñez-Barrios, Joan Font-Díaz, Carme Caelles, Annabel F Valledor, Paloma Pérez, Ana M Rojas, Juan Fernández-Recio, Diego M Presman, Gordon L Hager, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
Publikováno v:
Nucleic Acids Res
20 páginas, 7 figuras
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035f1b8140abc8c9d09b095720948efb
https://doi.org/10.1093/nar/gkac1119
https://doi.org/10.1093/nar/gkac1119
Autor:
Ana Paredes, Raquel Justo-Méndez, Daniel Jiménez-Blasco, Vanessa Núñez, Irene Calero, María Villalba-Orero, Andrea Alegre-Martí, Thierry Fischer, Ana Gradillas, Viviane Aparecida Rodrigues Sant’Anna, Felipe Were, Zhiqiang Huang, Pablo Hernansanz-Agustín, Carmen Contreras, Fernando Martínez, Emilio Camafeita, Jesús Vázquez, Jesús Ruiz-Cabello, Estela Area-Gómez, Fátima Sánchez-Cabo, Eckardt Treuter, Juan Pedro Bolaños, Eva Estébanez-Perpiñá, Francisco Javier Rupérez, Coral Barbas, José Antonio Enríquez, Mercedes Ricote
Publikováno v:
Nature.
Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from glucose to fatty acids for postnatal energy production1,2. This adaptation is triggered in part by post-partum environmental changes3, but the molecules orche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be78cc3825500859c8e20538935435db
https://doi.org/10.1038/s41586-023-06068-7
https://doi.org/10.1038/s41586-023-06068-7
Autor:
Andrea Alegre-Martí, Alba Jiménez-Panizo, Adrián Martínez-Tébar, Coralie Poulard, M. Núria Peralta-Moreno, Montserrat Abella, Rosa Antón, Marcos Chiñas, Ulrich Eckhard, Josep M. Piulats, Ana M. Rojas, Juan Fernández-Recio, Jaime Rubio-Martínez, Muriel Le Romancer, Álvaro Aytes, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
Publikováno v:
Science Advances. 9
Mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome may profoundly influence its structure, protein interaction network, and binding to chromatin, resulting in altered transcription signatures a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69333d34848947c0040543f0ff08bb7
https://doi.org/10.1126/sciadv.ade2175
https://doi.org/10.1126/sciadv.ade2175
Autor:
Elena Carceller‐Zazo, Lisa M. Sevilla, Omar Pons‐Alonso, Álvaro Chiner‐Oms, Larbi Amazit, Thi An Vu, Géraldine Vitellius, Say Viengchareun, Iñaki Comas, Yan Jaszczyszyn, Montserrat Abella, Andrea Alegre‐Martí, Eva Estébanez‐Perpiñá, Marc Lombès, Paloma Pérez
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 37(1)
17 páginas, 6 figuras
Glucocorticoids (GCs) exert potent antiproliferative and anti-inflammatory properties, explaining their therapeutic efficacy for skin diseases. GCs act by binding to the GC receptor (GR) and the mineralocorticoid receptor
Glucocorticoids (GCs) exert potent antiproliferative and anti-inflammatory properties, explaining their therapeutic efficacy for skin diseases. GCs act by binding to the GC receptor (GR) and the mineralocorticoid receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c637710d259351caaa258e6439428a
https://pubmed.ncbi.nlm.nih.gov/36527388
https://pubmed.ncbi.nlm.nih.gov/36527388
Topological dynamics of an intrinsically disordered N-terminal domain of the human androgen receptor
Autor:
Vahid Sheikhhassani, Barbara Scalvini, Julian Ng, Laurens W. H. J. Heling, Yosri Ayache, Tom M. J. Evers, Eva Estébanez‐Perpiñá, Iain J. McEwan, Alireza Mashaghi
Publikováno v:
Protein Science, 31(6):e4334. Wiley
Human androgen receptor contains a large N-terminal domain (AR-NTD) that is highly dynamic and this poses a major challenge for experimental and computational analysis to decipher its conformation. Misfolding of the AR-NTD is implicated in prostate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c89a039bd6914154a12ad0b2111eac
https://pubmed.ncbi.nlm.nih.gov/35634773
https://pubmed.ncbi.nlm.nih.gov/35634773
Autor:
Prasanna Kandel, Fatih Semerci, Rachana Mishra, William Choi, Aleksandar Bajic, Dodge Baluya, LiHua Ma, Kevin Chen, Austin C. Cao, Tipwarin Phongmekhin, Nick Matinyan, Alba Jiménez-Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes-Prior, Kevin R. MacKenzie, Caroline L. Benn, Eva Estébanez-Perpiñá, Koen Venken, David D. Moore, Damian W. Young, Mirjana Maletic-Savatic
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 13
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 13
Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately involved in learning and memory, mood, and stress response. Despite considerable progress in understanding the biology of neural stem cells and neurogenesis, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d0473efa092881a5a239cda1bba780
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8498
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8498
Autor:
Eva Estébanez-Perpiñá, Paloma Pérez, Juan Fernández-Recio, Theophilus Tettey, Montserrat Abella, Israel Nuñez-Barrios, Joan Font-Díaz, Pablo Fuentes-Prior, Andrea Alegre-Martí, Thomas A. Johnson, Annabel F. Valledor, Grégory Fettweis, Ana M. Rojas, Rosa Antón, Louis Schiltz, Gordon L. Hager, Diego M. Presman, Carme Caelles, Alba Jiménez-Panizo
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1b374e604facc55e11adedf88834bd
https://doi.org/10.1101/2021.10.01.462734
https://doi.org/10.1101/2021.10.01.462734