Výsledky vyhledávání

AZD5634, an inhaled ENaC inhibitor, in healthy subjects and patients with cystic fibrosis

Autor: Cecilia Kristensson, Annika Åstrand, Scott Donaldson, Ron Goldwater, Raolat Abdulai, Naimish Patel, Philip Gardiner, Ulrika Tehler, Anne-Kristina Mercier, Marita Olsson, Eva Ersdal, Jukka Mäenpää, Tobias Bramer, Anna Malmgren, William Bennett, Christina Keen

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 21(4)

Epithelial sodium channel (ENaC) inhibitors may offer clinical benefit in cystic fibrosis (CF); however, data are limited. We report the outcomes of a Phase I (NCT02679729) and a Phase Ib (NCT02950805) study of AZD5634, a novel inhaled ENaC inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fb734b98ab00379b34a1d1437433cc
https://pubmed.ncbi.nlm.nih.gov/35227647

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The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial

Publikováno v: International Journal of COPD, Vol Volume 13, Pp 1009-1019 (2018)
International Journal of Chronic Obstructive Pulmonary Disease

Naimish R Patel,1,2 Danen M Cunoosamy,1 Malin Fagerås,1 Ziad Taib,1 Sara Asimus,1 Tove Hegelund-Myrbäck,1 Sofia Lundin,1 Katerina Pardali,1 Nisha Kurian,1 Eva Ersdal,1 Cecilia Kristensson,1 Katarina Korsback,1 Robert Palmér,1 Mary N Brown,3 Steven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc971bb0133335d290426b49c4940a2
https://www.dovepress.com/the-development-of-azd7624-for-prevention-of-exacerbations-in-copd-a-r-peer-reviewed-article-COPD

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Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the .beta.-antithrombin III isoform with enhanced heparin affinity

Autor: Susan Clark Bock, Veronique Picard, Eva Ersdal-Badju

Publikováno v: Biochemistry. 34:8433-8440

Two antithrombin III (ATIII) isoforms occur naturally in human plasma. The alpha-ATIII isoform has four N-linked oligosaccharides attached to asparagines 96, 135, 155, and 192. The beta-ATIII isoform lacks carbohydrate on asparagine-135 (N135), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453448f04665107c5aaf39922dbeeb72
https://doi.org/10.1021/bi00026a026

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No influence of food on the pharmacokinetics, pharmacodynamics or tolerability of the 24mg and 36mg oral tablet formulations of ximelagatran

Autor: Eva Ersdal, Carina Lönnerstedt, Lis Ohlsson, Kajs-Marie Schützer, Ulrika Wall, Ulf Eriksson

Publikováno v: Clinical drug investigation. 25(7)

Objective: To assess the potential effects of food on the pharmacokinetics and tolerability/safety of ximelagatran, an oral direct thrombin inhibitor developed for the prevention and treatment of thromboembolic disease that is rapidly bioconverted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364df3c51058c54a837a66fda56af144
https://pubmed.ncbi.nlm.nih.gov/17532684

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Identification of the antithrombin III heparin binding site

Autor: Yancheng Zuo, Susan Clark Bock, Veronique Picard, Eva Ersdal-Badju, Aiqin Lu

Publikováno v: The Journal of biological chemistry. 272(31)

The heparin binding site of the anticoagulant protein antithrombin III (ATIII) has been defined at high resolution by alanine scanning mutagenesis of 17 basic residues previously thought to interact with the cofactor based on chemical modification ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849f154ce69cfdbd5f592f15035e6093
https://pubmed.ncbi.nlm.nih.gov/9235938

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Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a beta-like variant in baculovirus-infected insect cells

Autor: Eva Ersdal-Badju, Veronique Picard, Aiqin Lu, Steven T. Olson, Xiaoming Peng, Ingemar Björk, Susan Clark Bock, Boris Turk, P. Zendehrouh

In order to promote homogeneity of recombinant antithrombin III interactions with heparin, an asparagine-135 to alanine substitution mutant was expressed in baculovirus-infected insect cells. The N135A variant does not bear an N-linked oligosaccharid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e28fed5b50314864154cf2d86d040e3
https://europepmc.org/articles/PMC1135891/

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Binding of coagulation factor XI to washed human platelets

Autor: Peter N. Walsh, Mary J. Heeb, Eva Ersdal, John H. Griffin, Judith S. Greengard

Publikováno v: Biochemistry. 25:3884-3890

The binding of human coagulation factor XI to washed human platelets was studied in the presence of zinc ions, calcium ions, and high molecular weight kininogen. Significant factor XI binding occurred at physiological levels of these metal ions when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5344ce5fc85743fa39ccca6b788dee
https://doi.org/10.1021/bi00361a022

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