Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Eva Enmark"'
Estrogen receptor beta is expressed in human embryonic brain cells and is regulated by 17β-estradiol
Autor:
Eva Enmark, C. Österlund, Linda Csöregh, A. Aanesen, Eva Andersson, Jan-Åke Gustafsson, Gabriel Fried
Publikováno v:
European Journal of Neuroscience. 20:2345-2354
In order to study estrogen effects on developing human neurons, we have established primary cultures of neurons and glia from 8-13-week human embryo cortex and spinal cord. The neuronal identity of the cultures was verified using the neuronal synapti
Autor:
Karin Dahlman-Wright, Eva Enmark, Jan-Åke Gustafsson, Chunyan Zhao, Andrew Sunters, Eric Lam, Manuela Tamburo De Bella, R. Charles Coombes
Publikováno v:
Oncogene. 22:7600-7606
Two novel estrogen receptor beta (ERbeta) mRNA isoforms that diverge in their 5'-untranslated regions, ERbeta mRNA (0K-1) and ERbeta mRNA (0N-1), have recently been identified. This indicates that transcription of the human ERbeta gene occurs from at
Autor:
Giuseppe Pollio, Elisabetta Vegeto, Cesare Patrone, Eva Enmark, Jan-Åke Gustafsson, Ivan de Curtis, Adriana Maggi
Publikováno v:
Endocrinology. 141:1839-1845
Estrogens are female sex steroids that have a plethora of effects on a wide range of tissues. These effects are mediated through two well characterized intracellular receptors: estrogen receptor α and β (ERα and ERβ, respectively). Because of the
Autor:
Stephen Safe, Eva Enmark, George G.J.M. Kuiper, Fan Wang, Mark Wormke, Jan-Åke Gustafsson, Brad Saville, Thu Annelise Nguyen
Publikováno v:
Journal of Biological Chemistry. 275:5379-5387
17beta-Estradiol (E2) induces expression of several genes via estrogen receptor (ER)-Sp1 protein interactions with GC-rich promoter elements in which Sp1 but not ER binds DNA. This study reports the ligand- and cell context-dependent ER(alpha)/Sp1 an
Autor:
Phuong Nguyen, Eva Enmark, Jan-Åke Gustafsson, Gabriela N. Lopez, Benita S. Katzenellenbogen, Peter J. Kushner, Cathleen D. Valentine, Paul Webb, Eileen M. McInerney, Stefan Nilsson, Grace R. Kwok
Publikováno v:
Molecular Endocrinology. 13:1672-1685
Estrogen receptors (ERs alpha and beta) enhance transcription in response to estrogens by binding to estrogen response elements (EREs) within target genes and utilizing transactivation functions (AF-1 and AF-2) to recruit p160 coactivator proteins. T
Autor:
Eva Enmark, Jan-Åke Gustafsson
Publikováno v:
Journal of Internal Medicine. 246:133-138
The oestrogen receptor (ER) is a ligand-activated transcription factor that mediates the effects of the steroid hormone 17beta-oestradiol in both males and females. Since the isolation and cloning of ER, the prevailing opinion has been that only one
Autor:
Eva Enmark, Jan-Ake Gustafsson
Publikováno v:
Endocrine Related Cancer. 5:213-222
Publikováno v:
Molecular Pharmacology. 54:105-112
The existence of two rather than one estrogen receptor, today characterized as estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), indicates that the mechanism of action of 17beta-estradiol and related synthetic drugs is more compl
Autor:
Gabriel Fried, Kaj Grandien, Jacob Lagercrantz, Magnus Nordenskjöld, Svetlana Lagercrantz, Markku Pelto-Huikko, Eva Enmark, Jan-Åke Gustafsson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 82:4258-4265
The estrogen receptor (ER) is a ligand-activated transcription factor that mediates the effects of the steroid hormone 17β-estradiol, in both males and females. Since the isolation and cloning of ER, the consensus has been that only one such recepto
Publikováno v:
Brain Research. 743:315-319
In the present study, we report the localization of the Rev-ErbA alpha and beta nuclear orphan receptors, two closely related members of the nuclear hormone receptor superfamily, in the brain. Both Rev-ErbA variant mRNAs were highly expressed in the