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Novel NOD2 Mutation in Early-Onset Inflammatory Bowel Phenotype

Autor: Costantino De Giacomo, Diego Vozzi, Gabriele Baj, Eva Decleva, Alessia Pin, E.F. Stacul, Martina Girardelli, Anna Monica Bianco, Claudia Loganes, Alberto Tommasini

Publikováno v: Inflammatory bowel diseases. 24(6)

BACKGROUND: Nucleotide-binding oligomerization domain 2 (NOD2) is a key intracellular protein of the innate immune system. NOD2 variants are associated with inflammatory bowel disease (IBD) and other inflammatory phenotypes. We described the case of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17a4e92f76dc2000e6564811be0f0bb
https://pubmed.ncbi.nlm.nih.gov/29697845

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Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils

Autor: Fabio Tentor, Pasquale Sacco, Renzo Menegazzi, Massimiliano Borgogna, Sergio Paoletti, Eleonora Marsich, Kåre Andre Kristiansen, Kjell Morten Vårum, Eva Decleva

Publikováno v: Sacco, P, Decleva, E, Tentor, F, Menegazzi, R, Borgogna, M, Paoletti, S, Kristiansen, K A, Vårum, K M & Marsich, E 2017, ' Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils ', Macromolecular Bioscience, vol. 17, no. 11, 1700214 . https://doi.org/10.1002/mabi.201700214

Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b05c43597c09969225ac21db6a835
https://hdl.handle.net/11368/2912461

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Intracellular shunting of O2− contributes to charge compensation and preservation of neutrophil respiratory burst in the absence of voltage-gated proton channel activity

Autor: Pietro Dri, Alba Fasolo, Renzo Menegazzi, F. Defendi, Eva Decleva, Michele Sebastianutto

Publikováno v: Experimental Cell Research

Proton efflux via voltage-gated proton channels (Hv1) is considered to mediate the charge compensation necessary to preserve NADPH oxidase activity during the respiratory burst. Using the Hv1 inhibitor Zn2+, we found that the PMA-induced respiratory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52285ee386d257e9bd6959a00787f133
https://doi.org/10.1016/j.yexcr.2013.03.031

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Chloride Movements in Human Neutrophils during Phagocytosis: Characterization and Relationship to Granule Release

Autor: Elisa Trevisan, Sara Busetto, Pietro Dri, Renzo Menegazzi, Eva Decleva

Publikováno v: The Journal of Immunology. 179:4110-4124

Chloride ion efflux is an early event occurring after exposure of human neutrophils to several soluble agonists. Under these circumstances, a rapid and reversible fall in the high basal intracellular chloride (Cl−i) levels is observed. This event i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffcfb4380169c411fcfd193d86cb61c
https://doi.org/10.4049/jimmunol.179.6.4110

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Killing by neutrophil extracellular traps: fact or folklore?

Autor: Renzo Menegazzi, Eva Decleva, Pietro Dri

Publikováno v: Blood. 119:1214-1216

Neutrophil extracellular traps (NETs) are DNA structures released by dying neutrophils and claimed to constitute a new microbicidal mechanism. Killing by NET-forming cells is ascribed to these structures since it is prevented by preincubation with DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713e3bb9d5d24c7276a344ff40add65c
https://doi.org/10.1182/blood-2011-07-364604

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Evidence that TNF-induced respiratory burst of adherent PMN is mediated by integrin αLβ2

Autor: Eva Decleva, Sara Busetto, Rita Cramer, Renzo Menegazzi, Pietro Dri

Publikováno v: Journal of Leukocyte Biology. 72:718-726

Polymorphonuclear leukocytes (PMN) respond to tumor necrosis factor (TNF) with a respiratory burst (RB) only after adherence to surfaces coated with extracellular matrix proteins such as fibronectin and fibrinogen (permissive substrates) but not with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8d03c95cc04b2e22cfc5f790c7e2199
https://doi.org/10.1189/jlb.72.4.718

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Measurement of phagosomal pH of normal and CGD-like human neutrophils by dual fluorescence flow cytometry

Autor: Gianni Presani, Eva Decleva, Mario Prodan, Lavinia Albéri, Sandra Perticarari, Pietro Dri

Publikováno v: Cytometry. 48:159-166

Background Phagosomal pH is thought to play an important role in the antimicrobial activity of polymorphonuclear leukocytes (PMNs). In this study, we set up a method for a rapid and accurate measurement of phagosomal pH in PMNs with the use of Candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c045695dc63fd7385d8496e912576654
https://doi.org/10.1002/cyto.10123

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A novel point mutation in the CYBB gene promoter leading to a rare X minus chronic granulomatous disease variant--impact on the microbicidal activity of neutrophils

Autor: Cécile Martel, Marie José Stasia, F. Defendi, Pietro Dri, Eva Decleva

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2009, 1792 (3), pp.201. ⟨10.1016/j.bbadis.2009.01.005⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2009, 1792 (3), pp.201-10. ⟨10.1016/j.bbadis.2009.01.005⟩

International audience; This article reports an atypical and extremely rare case of X-linked CGD in an Italian family characterized by a low expression of gp91phox (X91- CGD). A novel point mutation in the CYBB gene's promoter (insertion of a T at po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69c3830a3fedc74b1e4edf409a3aab0
http://hdl.handle.net/11368/2742698

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