Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2

Autor: Sophie Papa, James Spicer, Debra H Josephs, Giulia Pellizzari, Olivier Martinez, Silvia Crescioli, Robert Page, Ashley Di Meo, Silvia Mele, Giulia Chiaruttini, Jan Hoinka, Ihor Batruch, Ioannis Prassas, Melanie Grandits, Jacobo López-Abente, Eva Bugallo-Blanco, Malcolm Ward, Heather J Bax, Elise French, Anthony Cheung, Sara Lombardi, Mariangela Figini, Katie E Lacy, Eleftherios P Diamandis, Sophia N Karagiannis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Background Cancer immunotherapy with monoclonal antibodies and chimeric antigen receptor (CAR) T cell therapies can benefit from selection of new targets with high levels of tumor specificity and from early assessments of efficacy and safety to deris

Externí odkaz: https://doaj.org/article/836d29985b964cc8b16ff8085298d717

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

Autor: Michelle L. Tas, Eleonora Khabirova, Christina Burke, Gerda Kildisiute, Giuseppe Barone, Matthew D. Young, Karin Straathof, Omer Ali Bayraktar, Waleed M. Kholosy, Clarissa N. Pacyna, Sam Behjati, Rasa Elmentaite, Xiaoling He, Philip Lijnzaad, Marc H. W. A. Wijnen, John C. Achermann, Ignacio del Valle, Eva Bugallo-Blanco, Kerstin B. Meyer, Ronald R. de Krijger, Alice Piapi, Thanasis Margaritis, Muzlifah Haniffa, Lira Mamanova, Karin P.S. Langenberg-Ververgaert, Dyanne Rampling, Max M. van Noesel, Frank C. P. Holstege, Kenny Roberts, John Anderson, Roger A. Barker, Sarah A. Teichmann, Sander R. van Hooff, Kaylee M. Keller, Neil J. Sebire, Christine Thevanesan, Reinier van der Linden, Catriona Duncan, Jan J. Molenaar

Publikováno v: Science advances, 7(6), 1. American Association for the Advancement of Science
Science Advances

Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e8b940f5b241956fe725bfb610727a
https://dspace.library.uu.nl/handle/1874/412169

Single cell derived mRNA signals across human kidney tumors

Autor: Eleonora Khabirova, Vincent J. Gnanapragasam, Tim H. H. Coorens, Adam Shlien, Nicholas Coleman, Omer Ali Bayraktar, Gerda Kildisiute, Muzlifah Haniffa, Federico Comitani, Roger A. Barker, Neil J. Sebire, Christine Thevanesan, Christina Burke, Kerstin B. Meyer, Stefan M. Pfister, Lars Custers, Dyanne Rampling, Karin Straathof, Elena Prigmore, Sarah A. Teichmann, Eva Bugallo-Blanco, Sam Behjati, Anne Y. Warren, Marry M. van den Heuvel-Eibrink, Thomas Rw Oliver, Ronald R. de Krijger, Ignacio del Valle, John Achermann, Anna Wilbrey-Clark, Kenny Roberts, Xiaoling He, Marcel Kool, Alice Piapi, Thanasis Margaritis, Jarno Drost, Felipe A. Vieira Braga, Kwasi Kwakwa, Kirsty Ambridge, Frank C. P. Holstege, Francisco Morales, Matthew D. Young, Thomas J. Mitchell, Grant D. Stewart, Liz Hook, Lira Mamanova

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ea3a6c350ed5f0cfab4351fb6694a1
https://pubmed.ncbi.nlm.nih.gov/34162837

A dynamic COVID-19 immune signature includes associations with poor prognosis

Autor: Aislinn Jennings, Isaac Francos-Quijorna, Manu Shankar-Hari, Adrian Hayday, Duncan R. McKenzie, John Cason, Thomas Hayday, Shraddha Kamdar, Yin Wu, Richard Davis, Matthew Fish, Kate Brooks, Blair Merrick, Katie J. Doores, Eva Bugallo-Blanco, Adam Laing, Kai Kisand, Jeremy Mason, Iva Zlatareva, Kola Babalola, Magdalene Joseph, Francesca Di Rosa, Jeffrey Seow, Philippe Moingeon, Anna Lorenc, Pärt Peterson, Daniel Davies, Mohammad A. A. Ibrahim, Efstathios Theodoridis, Federico Lopez Gomez, Liis Haljasmägi, Pierre Vantourout, Vasiliki Sofra, Abhishek Das, Maria Greco, Christine Mant, Sarah Gee, Julie Nuo En Chan, Carl Graham, Leticia Monin, Loubna Chadli, Irene del Molino del Barrio, Miguel Muñoz-Ruiz, Florencia Cano, Karen Bisnauthsing, Lauren Martinez, Sultan Abdul-Jawad, Sarah Ryan, Jonathan D. Edgeworth, Joshua D. Freedman

Publikováno v: Nature medicine
26 (2020): 1623–1635. doi:10.1038/s41591-020-1038-6
info:cnr-pdr/source/autori:Laing, Adam G.; Lorenc, Anna; del Molino del Barrio, Irene; Das, Abhishek; Fish, Matthew; Monin, Leticia; Muñoz-Ruiz, Miguel; McKenzie, Duncan R.; Hayday, Thomas S.; Francos-Quijorna, Isaac; Kamdar, Shraddha; Joseph, Magdalene; Davies, Daniel; Davis, Richard; Jennings, Aislinn; Zlatareva, Iva; Vantourout, Pierre; Wu, Yin; Sofra, Vasiliki; Cano, Florencia; Greco, Maria; Theodoridis, Efstathios; Freedman, Joshua; Gee, Sarah; Chan, Julie Nuo En; Ryan, Sarah; Bugallo-Blanco, Eva; Peterson, Pärt; Kisand, Kai; Haljasmägi, Liis; Chadli, Loubna; Moingeon, Philippe; Martinez, Lauren; Merrick, Blair; Bisnauthsing, Karen; Brooks, Kate; Ibrahim, Mohammad A.A.; Mason, Jeremy; Lopez Gomez, Federico; Babalola, Kola; Abdul-Jawad, Sultan; Cason, John; Mant, Christine; Seow, Jeffrey; Graham, Carl; Doores, Katie J.; Di Rosa, Francesca; Edgeworth, Jonathan; Shankar-Hari, Manu; Hayday, Adrian C./titolo:A dynamic COVID-19 immune signature includes associations with poor prognosis/doi:10.1038%2Fs41591-020-1038-6/rivista:Nature medicine (Print)/anno:2020/pagina_da:1623/pagina_a:1635/intervallo_pagine:1623–1635/volume:26
Nature Medicine

Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f5fa781e4a5acfc0a8216290f81914
http://www.cnr.it/prodotto/i/439414