Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Eva Biener"'
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Akademický článek
A blood-based transcriptomic signature stratifies severe Crohn’s disease and defines potentially targetable therapeutic pathways
Autor: Rivkah Gonsky, Evan Adams, Alka A. Potdar, Gregory Botwin, Eva Biener-Ramanujan, Dermot P. B. McGovern, Jonathan G. Braun, Phillip Fleshner, Stephan R. Targan
Publikováno v: Frontiers in Gastroenterology, Vol 2 (2023)
IntroductionDespite advances in medical therapy, many patients with Crohn’s disease (CD) ultimately require surgery for disease management. Identifying the underlying molecular pathways for subgroup stratification is critical to the improvement of
Externí odkaz: https://doaj.org/article/5c66e76b02cb4b21a54c4696ade7391e
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2
Akademický článek
Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion
Autor: Eva Biener-Ramanujan, Florian Rosier, Simon G. Coetzee, Dermot D. P. McGovern, Dennis Hazelett, Stephan R. Targan, Rivkah Gonsky
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Ribonuclease T2 gene (RNASET2) variants are associated in genome wide association studies (GWAS) with risk for several autoimmune diseases, including Crohn’s disease (CD). In T cells, a functional and biological relationship exists between TNFSF15-
Externí odkaz: https://doaj.org/article/f805e64266754b1e95e29caa4b3ed0b0
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5
DOP29 Elevation of a novel blood-based gene signature in a severe Crohn’s disease (CD) subtype preceding surgery defines and predicts a post-surgical decrease in pro-inflammatory pathway activation
Autor: S. R. Targan, Gregory J. Botwin, Eva Biener-Ramanujan, Dermot P.B. McGovern, Philip Fleshner, Rebecca Gonsky
Publikováno v: Journal of Crohn's and Colitis. 14:S068-S069
Background CD is defined by transmural inflammation leading to inflammatory, stricturing and/or penetrating phenotypes. Identifying underlying molecular pathways and distinct disease subsets is critical for improved prognostics, therapeutics and biom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b7d1482fc136658eb98e023269cbe73
https://doi.org/10.1093/ecco-jcc/jjz203.068
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6
Targeting metabolic plasticity in breast cancer cells via mitochondrial complex I modulation
Autor: Qijin Xu, Wei Yang, Eva Biener-Ramanujan, V. Krishnan Ramanujan
Publikováno v: Breast Cancer Research and Treatment. 150:43-56
Heterogeneity commonly observed in clinical tumors stems both from the genetic diversity as well as from the differential metabolic adaptation of multiple cancer types during their struggle to maintain uncontrolled proliferation and invasion in vivo.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a86395092c3bb4a797ca04523598db8
https://doi.org/10.1007/s10549-015-3304-8
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9
Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease
Autor: Stephan R. Targan, Shaohong Yang, Phillip Fleshner, Richard L. Deem, Rivkah Gonsky, Dermot P.B. McGovern, Dalin Li, Eva Biener-Ramanujan, Alka A. Potdar, Janine Bilsborough
Publikováno v: Gastroenterology. 153(1)
Background & Aims Variants in the tumor necrosis factor superfamily member 15 gene ( TNFSF15 , also called TL1A ) have been associated with risk for inflammatory bowel disease (IBD). TL1A affects expression of multiple cytokines to promote mucosal in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0501574f10877b13950a6687e0038854
https://pubmed.ncbi.nlm.nih.gov/34800423
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