Lung regeneration after toxic injury is improved in absence of dioxin receptor

Autor: Antonio Morales-Hernández, Ana Nacarino-Palma, Nuria Moreno-Marín, Eva Barrasa, Beroé Paniagua-Quiñones, Inmaculada Catalina-Fernández, Alberto Alvarez-Barrientos, Xosé R. Bustelo, Jaime M. Merino, Pedro M. Fernández-Salguero

Publikováno v: Stem Cell Research, Vol 25, Iss C, Pp 61-71 (2017)

Recent experimental evidences from cellular systems and from mammalian and non-mammalian animal models highlight novel functions for the aryl hydrocarbon/dioxin receptor (AhR) in maintaining cell differentiation and tissue homeostasis. Notably, AhR d

Externí odkaz: https://doaj.org/article/74e389c33455468884dfe53c82f0a8c7

Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis

Autor: Antonio Morales-Hernández, Eva Barrasa, Pedro M. Fernández-Salguero, Beroe Paniagua, Jaime M. Merino, Nuria Moreno-Marín, Gerardo Blanco-Fernández

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports

The aryl hydrocarbon receptor (AhR) has roles in cell proliferation, differentiation and organ homeostasis, including the liver. AhR depletion induces undifferentiation and pluripotency in normal and transformed cells. Here, AhR-null mice (AhR−/−

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55730ef12d627c2fd0b51616b41df677
http://link.springer.com/article/10.1038/s41598-017-10984-w

The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis

Autor: Xosé R. Bustelo, María Contador-Troca, Pedro M. Fernández-Salguero, Mauricio Menacho-Márquez, Alberto Álvarez-Barrientos, Eva Barrasa, José C. García-Borrón, Javier Sáenz-Santamaría, Inmaculada Catalina-Fernández, Eva M. Rico-Leo, Aurea Gomez-Duran

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

et al.
Melanoma is a highly metastatic and malignant skin cancer having poor rates of patient survival. Since the incidence of melanoma is steadily increasing in the population, finding prognostic and therapeutic targets are crucial tasks in can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54fc781b3a997a8cf734c5db50a05a6
https://doi.org/10.1093/carcin/bgt248

Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

Autor: Francisco Javier Oliver, Pedro M. Fernández-Salguero, Jaime M. Merino, Javier Sáenz-Santamaría, Alberto Álvarez-Barrientos, Inmaculada Catalina-Fernández, Maria Isabel Cerezo-Guisado, Eva Barrasa, Antonio Morales-Hernández, María Isabel Rodríguez, Javier Rey-Barroso, María Contador-Troca

Publikováno v: Molecular Cancer
Molecular Cancer, 2015, 14 (1), pp.148. ⟨10.1186/s12943-015-0419-9⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

[Background] The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3fdd72207723bde6dace7c48228a76
https://doi.org/10.1186/s12943-015-0419-9