Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Autor: Esther de Jong, Hilko van der Voet, Philip Marx‐Stoelting, Susanne Hougaard Bennekou, Corinne Sprong, Denise Bloch, Alina Burchardt, Alexandra Lasch, Tobias Opialla, Stefanie Rotter, Eva Bay Wedebye, Anne Zwartsen, Anke Leys, Maryam Zare Jeddi, Gerrit Wolterink, Johannes Kruisselbrink, Waldo de Boer, Jacob van Klaveren

Publikováno v: EFSA Supporting Publications, 19(10)
EFSA Supporting Publications 19 (2022) 10

EFSA's aim by 2030, is that the Agency and its partners will be equipped for the routine implementation of human health risk assessment to multiple chemicals, across EFSA's domains of activity. To facilitate this effort, a roadmap for action has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0358dba7593d5ff211b4e2abd96cb22b
https://doi.org/10.2903/sp.efsa.2022.en-7555

QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances

Autor: Kazue Chinen, Nikolai Georgiev Nikolov, Eva Bay Wedebye, Kyrylo Klimenko, Camilla Taxvig

Publikováno v: Chinen, K K, Klimenko, K, Taxvig, C, Nikolov, N G & Wedebye, E B 2020, ' QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances ', Computational Toxicology, vol. 14, 100121 . https://doi.org/10.1016/j.comtox.2020.100121
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Funding Information: We would like to thank Informatics leader, Senior scientist Ruili Huang from the U.S. National Institute of Health for support on the Tox21 data interpretation. This work was financially supported by the Danish Environmental Prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28dd399c5e56461e09f63215fd727e1
https://hdl.handle.net/10362/119400

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Autor: Geven Piir, Paola Gramatica, Vinicius M. Alves, Uko Maran, Xianliang Qiao, Michel Petitjean, Christopher M. Grulke, Karl-Werner Schramm, Giuseppe Felice Mangiatordi, Antony J. Williams, Barun Bhhatarai, Sherif Farag, Alexey V. Zakharov, Chetan Rupakheti, Emilio Benfenati, Weida Tong, Chandrabose Selvaraj, Eva Bay Wedebye, Fang Bai, Sugunadevi Sakkiah, Nicole Kleinstreuer, Ann M. Richard, Orazio Nicolotti, Huixiao Hong, George Van Den Driessche, Ilya A. Balabin, Eugene N. Muratov, Imran Shah, Ulf Norinder, Jiazhong Li, Huanxiang Liu, Viviana Consonni, Igor V. Tetko, Pavel V. Pogodin, Ruili Huang, Ester Papa, Ahmed Abdelaziz, Dragos Horvath, Alexandre Varnek, Patricia Ruiz, Carolina Horta Andrade, Domenico Alberga, Ziye Zheng, Roberto Todeschini, Daniela Trisciuzzi, Nina Jeliazkova, Xuehua Li, Dac-Trung Nguyen, Gilles Marcou, Zhongyu Wang, Kamel Mansouri, Alexander Tropsha, Yun Tang, Alessandro Sangion, Todd M. Martin, Xin Hu, Scott Boyer, Hongbin Xie, Serena Manganelli, Richard S. Judson, Nikolai Georgiev Nikolov, Jingwen Chen, Denis Fourches, Vladimir Poroikov, Alfonso T. García-Sosa, Alessandra Roncaglioni, Davide Ballabio, Patrik L. Andersson, Sulev Sild, Francesca Grisoni, Lixia Sun, Olivier Taboureau

Publikováno v: Environmental Health Perspectives
Mansouri, K, Kleinstreuer, N, Abdelaziz, A M, Alberga, D, Alves, V M, Andersson, P L, Andrade, C H, Bai, F, Balabin, I, Ballabio, D, Benfenati, E, Bhhatarai, B, Boyer, S, Chen, J, Consonni, V, Farag, S, Fourches, D, García-Sosa, A T, Gramatica, P, Grisoni, F, Grulke, C M, Hong, H, Horvath, D, Hu, X, Huang, R, Jeliazkova, N, Li, J, Li, X, Liu, H, Manganelli, S, Mangiatordi, G F, Maran, U, Marcou, G, Martin, T, Muratov, E, Nguyen, D-T, Nicolotti, O, Nikolov, N G, Norinder, U, Papa, E, Petitjean, M, Piir, G, Pogodin, P, Poroikov, V, Qiao, X, Richard, A M, Roncaglioni, A, Ruiz, P, Rupakheti, C, Sakkiah, S, Sangion, A, Schramm, K-W, Selvaraj, C, Shah, I, Sild, S, Sun, L, Taboureau, O, Tang, Y, Tetko, I V, Todeschini, R, Tong, W, Trisciuzzi, D, Tropsha, A, Van Den Driessche, G, Varnek, A, Wang, Z, Wedebye, E B, Williams, A J, Xie, H, Zakharov, A V, Zheng, Z & Judson, R S 2020, ' CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity ', Environmental Health Perspectives, vol. 128, no. 2, 027002 . https://doi.org/10.1289/ehp5580
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2020, 128 (2), pp.027002. ⟨10.1289/EHP5580⟩

Background:Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7005b1d9a5d2e302730cc73ba1c96554
http://europepmc.org/articles/PMC7064318

How many vPvM/PMT substances have been registered under REACH? - vPvM/PMT screening by using the Danish QSAR database

Autor: Holmberg, R., Eva Bay Wedebye, Nikolai Georgiev Nikolov, Tyle, K.

Publikováno v: Holmberg, R, Wedebye, E B, Nikolov, N G & Tyle, K 2018, How many vPvM/PMT substances have been registered under REACH?-vPvM/PMT screening by using the Danish QSAR database . in SETAC Europe 28th Annual Meeting-Abstract book ., WE072, Society of Environmental Toxicology and Chemistry, Brussels, Belgium, pp. 346-346, SETAC Europe 28th Annual Meeting, Rome, Italy, 13/05/2018 .
Technical University of Denmark Orbit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::05f6540938cb3a18720aa4be1ceb9b3c
http://orbit.dtu.dk/en/publications/how-many-vpvmpmt-substances-have-been-registered-under-reach--vpvmpmt-screening-by-using-the-danish-qsar-database(26914a9f-9088-4ec9-956c-71e6b94f448c).html

QSAR development and profiling of 72,524 REACH substances for PXR activation and CYP3A4 induction

Autor: Nikolai Georgiev Nikolov, M. Xia, Marianne Dybdahl, Eva Bay Wedebye, Ruili Huang, Sine Abildgaard Rosenberg

Publikováno v: Abildgaard Rosenberg, S, Xia, M, Huang, R, Nikolov, N G, Wedebye, E B & Dybdahl, M 2017, ' QSAR development and profiling of 72,524 REACH substances for PXR activation and CYP3A4 induction ', Computational Toxicology, vol. 1, pp. 39-48 . https://doi.org/10.1016/j.comtox.2017.01.001

The Pregnane X Receptor (PXR) is a key regulator of enzymes, for example the cytochrome P450 isoform 3A4 (CYP3A4), and transporters involved in the metabolism and excretion of xenobiotics and endogenous compounds. Activation of PXR by xenobiotics cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3dee7c4b8e4e29b9f1d4e3dc98be11
https://orbit.dtu.dk/en/publications/027cba4e-adf2-4dbf-bc48-229ec3081f96