Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eva, Tiecke"'
Autor:
Eva, Tiecke, Maurizio, Rainisio, Theodor, Guentert, Stephan, Müller, Liat, Hochman, Eli, Kaplan, Sara, Mangialaio
Publikováno v:
Clinical Pharmacology in Drug Development. 11:1012-1027
Painful diabetic peripheral neuropathy is characterized by burning, stabbing, or electric shock-type pain, which severely impacts day-to-day functioning and quality of life. Here, we report the results of 3 phase I studies with NRD135S.E1 (referred t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e83d963642dbf2a7b8caf0f6c7dc5e
https://doi.org/10.1002/cpdd.1103
https://doi.org/10.1002/cpdd.1103
Autor:
Eva Tiecke, Maurizio Rainisio, Elon Eisenberg, Julio Wainstein, Eli Kaplan, Michal Silverberg, Liat Hochman, Sara Mangialaio
Publikováno v:
European journal of pain (London, England). 26(8)
Painful diabetic peripheral neuropathy (PDPN) affects up to 26% of patients with diabetes mellitus, with major impacts on their general health and well-being. Most available drugs fail to deliver acceptable pain reduction in the majority of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44164287dedadbf5eceb43a2c359e77d
https://pubmed.ncbi.nlm.nih.gov/35671086
https://pubmed.ncbi.nlm.nih.gov/35671086
Autor:
Martin S. Tallman, Frederick R. Appelbaum, Bruno C. Medeiros, Richard F. Schlenk, Richard M. Stone, Andrew H. Wei, A. Ganser, Ling Du, Hartmut Döhner, Yuan Cheng, Gerhard Ehninger, Konstanze Döhner, Susan Geyer, Clara D. Bloomfield, Michael Heuser, Serena Lavorgna, Jurjen Jansen, Eva Tiecke, Jordi Sierra, Yi Chen, S. Amadori, Rebecca B. Klisovic, Dietger Niederweiser, Joseph Brandwein, Guido Marcucci, Thomas W. Prior, Richard A. Larson, T. de Witte, Jürgen Krauter, Miguel A. Sanz, Dan Jones, J. Nomdedeu, Maria Teresa Voso, Christian Thiede, Francesco Lo-Coco
Publikováno v:
HemaSphere. 3:79-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8c5c6c063f6f12da8ca862c871138bf
https://doi.org/10.1097/01.hs9.0000559236.73191.39
https://doi.org/10.1097/01.hs9.0000559236.73191.39
Autor:
Francesco Lo-Coco, Jorge Sierra, Joseph Brandwein, Joop H. Jansen, Andrew H. Wei, Thomas W. Prior, Richard A. Larson, J. Nomdedeu, Bruno C. Medeiros, Eva Tiecke, Richard F. Schlenk, Dietger Niederweiser, Konstanze Döhner, Michael Heuser, Christian Thiede, Hartmut Döhner, Sergio Amadori, Insa Gathmann, Theo de Witte, Richard Stone, Dan Jones, Miguel A. Sanz, Serena Lavorgna, Susan Geyer, Frederick R. Appelbaum, Yuan Cheng, Rebecca B. Klisovic, Jürgen Krauter, Guido Marcucci, Clara D. Bloomfield, Maria Teresa Voso, Arnold Ganser, Martin S. Tallman
Publikováno v:
Blood. 132:2668-2668
Introduction: Mutations localized in the tyrosine kinase domain activation loop of FLT3 (FLT3-TKD), representing point mutations in codon D835/I836 and rarely deletions of codon I836, induce constitutive tyrosine phosphorylation and activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25de0da5aff6b58ef5647790146bf2d5
https://doi.org/10.1182/blood-2018-99-114318
https://doi.org/10.1182/blood-2018-99-114318
Autor:
Celine Pallaud, Gerhard Ehninger, Insa Gathmann, Tamara J. Blätte, Axel Benner, Nikolaus Jahn, Joseph Brandwein, Julia Herzig, Thomas W. Prior, Richard A. Larson, Michael Heuser, Bruno C. Medeiros, Martin S. Tallman, Richard Stone, Clara D. Bloomfield, Frederick R. Appelbaum, Lars Bullinger, Christian Thiede, Sergio Amadori, Eva Tiecke, Konstanze Döhner, Ekaterina Panina, Anna Dolnik, Hartmut Döhner, Julia Krzykalla, Francesco Lo-Coco, Arnold Ganser
Publikováno v:
Blood. 132:1534-1534
Background: Recently, the oral multitargeted small molecule FLT3 inhibitor midostaurin (M) was approved for treatment of FLT3-mutated AML in combination with standard chemotherapy. In the international RATIFY (NCT00651261) trial, addition of M led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb284cd6b739be030bd2269a16252f9d
https://doi.org/10.1182/blood-2018-99-115842
https://doi.org/10.1182/blood-2018-99-115842
Autor:
Francesco Lo-Coco, Jorge Sierra, Michelle Geddes, Gerhard Ehninger, Hartmut Döhner, Ling Du, Joseph Brandwein, Insa Gathmann, Tamara J. Blätte, Frederick R. Appelbaum, Eva Tiecke, Christian Thiede, Konstanze Döhner, Thomas W. Prior, Richard A. Larson, Michael Heuser, Celine Pallaud, Arnold Ganser, Dietger Niederwieser, Bruno C. Medeiros, Miguel A. Sanz, Axel Benner, Martin S. Tallman, Theo de Witte, Sergio Amadori, Clara D. Bloomfield, Richard Stone, Julia Krzykalla, Lars Bullinger, Frank G. Rücker
Publikováno v:
Blood. 132:435-435
Introduction: Internal tandem duplication of the FLT3 gene (FLT3-ITD), resulting in duplication of 3 to more than hundreds of nucleotides, are present in approximately 25% of adults with newly diagnosed AML. Several studies have shown that ITD mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b2cf5234269c5e691986793554e11b
https://doi.org/10.1182/blood-2018-99-116149
https://doi.org/10.1182/blood-2018-99-116149
Autor:
Konstanze Döhner, Andrew H. Wei, Gerhard Ehninger, Clara D. Bloomfield, Eva Barragán, Jürgen Krauter, J. Nomdedeu, Celine Pallaud, Hartmut Döhner, Christian Thiede, Weiqiang Zhao, Serena Lavorgna, Xiaohong Li, Joop H. Jansen, Thomas W. Prior, Richard A. Larson, Richard Stone, Eva Tiecke
Publikováno v:
Blood. 132:2800-2800
Introduction: FLT3-mutations (FLT3mut) are the most common molecular alteration in younger adult patients with AML. The two major variants are internal tandem duplication (ITD) mutations mainly affecting the juxtamembrane domain and point mutations (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32975e7ca7513c8e7466edc556f0bb31
https://doi.org/10.1182/blood-2018-99-112127
https://doi.org/10.1182/blood-2018-99-112127
Autor:
Jean-Denis Bénazet, Alexandre Gonalves, Eva Tiecke, Rolf Zeller, Mirko Bischofberger, James F. Martin, Felix Naef, Aime Zuniga
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783642126826
RECOMB
RECOMB
Developmental pathways need to be robust against environmental and genetic variation to enable reliable morphogenesis Here, we take a systems biology approach to explain how robustness is achieved in the developing mouse limb, a classical model of or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3062ec9a020924793798a0cc5b72856f
https://doi.org/10.1126/science.1168755
https://doi.org/10.1126/science.1168755
Autor:
Shigeru Kuratani, Shigehiro Kuraku, Eva Tiecke, Nobuhiro Kokubo, Mikiko Tanaka, Manami Matsuura, Rie Kusakabe
Publikováno v:
Development Genes and Evolution. 217:691-697
We have identified two Tbx1/10-related genes, LjTbx1/10A and LjTbx1/10B, from the Japanese river lamprey Lethenteron japonicum. We used in situ hybridization to characterize their expression pattern during embryonic development. LjTbx1/10A and LjTbx1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c604c94a71a9d25001f38d5f43172b
https://doi.org/10.1007/s00427-007-0181-0
https://doi.org/10.1007/s00427-007-0181-0
Autor:
Antonella Galli, Javier Lopez-Rios, Alexandre Gonçalves, Florence Naillat, Eva Tiecke, Seppo Vainio, Konstantin Beier, Odyssé Michos, Rolf Zeller
Publikováno v:
Development. 134:2397-2405
Antagonists act to restrict and negatively modulate the activity of secreted signals during progression of embryogenesis. In mouse embryos lacking the extra-cellular BMP antagonist gremlin 1 (Grem1), metanephric development is disrupted at the stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b037df8420b97ff7f5ff6bed28da613e
https://doi.org/10.1242/dev.02861
https://doi.org/10.1242/dev.02861