Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Eva, Lion"'
Autor:
Ramiro Martinez, Chiara Finocchiaro, Louis Delhaye, Fien Gysens, Jasper Anckaert, Wim Trypsteen, Maarten Versteven, Eva Lion, Sandra Van Lint, Karim Vermaelen, Eric James de Bony, Pieter Mestdagh
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer cells effectively evade immune surveillance, not only through the well-known PD-1/PD-L1 pathway but also via alternative mechanisms that impair patient response to immune checkpoint inhibitors. We present a novel co-culture model that pairs a
Externí odkaz:
https://doaj.org/article/49b655d42ec24ce69326b7dd266ba321
Autor:
Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, Elly Marcq, Philippe Joye, Edgar Cardenas De La Hoz, Christophe Deben, Alessia Gasparini, Pierre Montay-Gruel, Maxim Le Compte, Eva Lion, Filip Lardon, Steven Van Laere, Vasiliki Siozopoulou, Diana Campillo-Davo, Jorrit De Waele, Patrick Pauwels, Julie Jacobs, Evelien Smits, Jonas R. M. Van Audenaerde
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background It remains challenging to obtain positive outcomes with chimeric antigen receptor (CAR)-engineered cell therapies in solid malignancies, like colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). A major obstacle is
Externí odkaz:
https://doaj.org/article/8761eb0063d942beb968b458b3b522ca
Autor:
Stijn Verhulst, Sven Dekeyzer, Griet Nijs, Maxime De Laere, Marie-Madeleine Couttenye, Zwi Berneman, Nathalie Cools, Manon Huizing, Ella Roelant, Toon Van Genechten, Jolien Van den Bossche, Barbara Stein, kim De Rycke, Caroline Deschepper, Katja Hazes, Renke Peeters, Katrien Van De Walle, Sabine Maes, Stephanie Vanden Bossche, Kim Caluwaert, Joris Verlooy, Koen Norga, Sebastien Anguille, Eva Lion
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Introduction Diffuse intrinsic pontine glioma (DIPG) and paediatric high-grade glioma (pHGG) are aggressive glial tumours, for which conventional treatment modalities fall short. Dendritic cell (DC)-based immunotherapy is being investigated as a prom
Externí odkaz:
https://doaj.org/article/448d729eeeb445d19d32a432ced49800
Autor:
Jolien Van den Bossche, Maxime De Laere, Koen Deschepper, Paul Germonpré, Yvan Valcke, Jan Lamont, Barbara Stein, Kirsten Van Camp, Charlotte Germonpré, Griet Nijs, Ella Roelant, Sébastien Anguille, Eva Lion, Zwi Berneman
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307204 (2024)
Malignant pleural mesothelioma (MPM) is an aggressive cancer with a very poor prognosis. Recently, immune checkpoint inhibition (ICI) has taken center stage in the currently ongoing revolution that is changing standard-of-care treatment for several m
Externí odkaz:
https://doaj.org/article/0fc25e2cc8ca4f028c79ed96487bc0db
Autor:
Donovan Flumens, Diana Campillo-Davo, Ibo Janssens, Gils Roex, Jorrit De Waele, Sébastien Anguille, Eva Lion
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102112- (2023)
Summary: To avoid mispairing between native and introduced T cell receptors (TCRs) and to prevent graft-versus-host disease in allogeneic T cell therapies, TCRα and TCRβ chains of native TCRs are knocked out via CRISPR-Cas9. We demonstrate the isol
Externí odkaz:
https://doaj.org/article/80548a7f7c2441c1b89199b1e11e0f9c
Autor:
Sanne van der Heijden, Donovan Flumens, Maarten Versteven, Stefanie Peeters, Hans De Reu, Diana Campillo-Davo, Yannick Willemen, Benson Ogunjimi, Viggo Van Tendeloo, Zwi N. Berneman, Sébastien Anguille, Evelien Smits, Eva Lion
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102053- (2023)
Summary: Wilms’ tumor protein 1 (WT1) is a tumor-associated antigen overexpressed in various cancers. As a self-antigen, negative selection reduces the number of WT1-specific T cell receptors (TCRs). Here, we provide a protocol to generate WT137-45
Externí odkaz:
https://doaj.org/article/00e507c283384e738fce78407e768998
Autor:
Gils Roex, Diana Campillo-Davo, Donovan Flumens, Philip Anthony Gilbert Shaw, Laurens Krekelbergh, Hans De Reu, Zwi N. Berneman, Eva Lion, Sébastien Anguille
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has proven to be a valuable new treatment option for patients with B-cell malignancies. However, by applying selective pressure, outgrowth of antigen-negative tumor cells can occur, e
Externí odkaz:
https://doaj.org/article/05c1c30b2722445782796239a7b077f8
Autor:
Gils Roex, Marijke Timmers, Kristien Wouters, Diana Campillo-Davo, Donovan Flumens, Wilfried Schroyens, Yiwei Chu, Zwi N. Berneman, Eva Lion, Feifei Luo, Sébastien Anguille
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic review and meta-analysis was to determine its safety and cli
Externí odkaz:
https://doaj.org/article/c5abce8e1fbc403397769e67dc74eb91
Autor:
Maarten Versteven, Donovan Flumens, Diana Campillo-Davó, Hans De Reu, Laura Van Bruggen, Stefanie Peeters, Viggo Van Tendeloo, Zwi Berneman, Harry Dolstra, Sébastien Anguille, Willemijn Hobo, Evelien Smits, Eva Lion
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Dendritic cell (DC) vaccines have proven to be a valuable tool in cancer immune therapy. With several DC vaccines being currently tested in clinical trials, knowledge about their therapeutic value has been significantly increased in the past decade.
Externí odkaz:
https://doaj.org/article/e0e0883d60f5415c9f97216c8a1d9417
Autor:
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi
Publikováno v:
eLife, Vol 11 (2022)
Antigen recognition through the T cell receptor (TCR) αβ heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naïve T cells with high specificity to expand and differentiate into memory T cells. However
Externí odkaz:
https://doaj.org/article/ef8d3322e4b24849bf9e4eef3c1cad40