Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eva, Emmell"'
Autor:
Kerry Brosnan, Mark L. Chiu, Eva Emmell, Catherine N. Leettola, Sandra Santulli-Marotto, Olesya Chornoguz, Karen Leander
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 38:242-254
Although CD3 T cell redirecting antibodies have been successfully utilized for the treatment of hematological malignancies (blinatumomab), the T cell signaling pathways induced by these molecules are incompletely understood. To gain insight into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354d7333c3e0f8da28fb537d86bc0088
https://doi.org/10.1089/mab.2019.0035
https://doi.org/10.1089/mab.2019.0035
Autor:
Dennis R. Goulet, Rose Decker, Jose Pardinas, Susan H. Tam, Eva Emmell, Mark L. Chiu, Songmao Zheng, Mehabaw G. Derebe, Catherine N. Leettola, Adam Zwolak
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Methods to rapidly generate high quality bispecific antibodies (BsAb) having normal half-lives are critical for therapeutic programs. Here, we identify 3 mutations (T307P, L309Q, and Q311R or “TLQ”) in the Fc region of human IgG1 which disrupt in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0a800975376ddc9448fee52cea3518
http://link.springer.com/article/10.1038/s41598-017-15748-0
http://link.springer.com/article/10.1038/s41598-017-15748-0
Autor:
Anthony A. Armstrong, Eva Emmell, Dennis R. Goulet, Songmao Zheng, Kerry Brosnan, Jose Pardinas, Jeffrey Luo, Susan H. Tam, Mark L. Chiu, Gary L. Gilliland, Adam Zwolak
Publikováno v:
mAbs
The increased number of bispecific antibodies (BsAb) under therapeutic development has resulted in a need for mouse surrogate BsAbs. Here, we describe a one-step method for generating highly pure mouse BsAbs suitable for in vitro and in vivo studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c47706163315d2d22e8a3cacbaa31f
https://doi.org/10.1080/19420862.2017.1375639
https://doi.org/10.1080/19420862.2017.1375639
Autor:
Olesya, Chornoguz, Catherine N, Leettola, Karen, Leander, Kerry, Brosnan, Eva, Emmell, Mark L, Chiu, Sandra, Santulli-Marotto
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Although CD3 T cell redirecting antibodies have been successfully utilized for the treatment of hematological malignancies (blinatumomab), the T cell signaling pathways induced by these molecules are incompletely understood. To gain insight into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f22cbae11fe53c81f3a482b4e1a8ed4
https://pubmed.ncbi.nlm.nih.gov/31825302
https://pubmed.ncbi.nlm.nih.gov/31825302
Autor:
Dorie Capaldi, Daniel Weinstock, Patricia Rafferty, Mindi Walker, Kjell Johnson, Kerry Brosnan, Amy Volk, Devon D Sominski, Eva Emmell
Publikováno v:
Journal of Immunotoxicology. 13:226-234
An important component of safety assessment of new pharmaceuticals is evaluation of their potential to increase the risk of developing cancer in humans. The traditional 2-year rodent bioassay often is not feasible or scientifically applicable for eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aebbf812ebf2a72e4f326b5b516b19
https://doi.org/10.3109/1547691x.2015.1045105
https://doi.org/10.3109/1547691x.2015.1045105
Autor:
Dorie Capaldi, Eva Emmell, Keri L. Soring, Jill Carton, Sharon Watson, Kerry Brosnan, Katharine D. Grugan, Allison R. Greenplate, Michelle Kinder, Randall J. Brezski, Theodore Petley, Robert Jordan
Publikováno v:
mAbs. 6:1265-1273
We report a chimeric monoclonal antibody (mAb) directed to a neo-epitope that is exposed in the IgG lower hinge following proteolytic cleavage. The mAb, designated 2095–2, displays specificity for IdeS-generated F(ab’)2 fragments, but not for ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b0967f17d400b056c1892f69e1d229
https://doi.org/10.4161/mabs.29825
https://doi.org/10.4161/mabs.29825
Autor:
Jose Pardinas, Adam Zwolak, Kerry Brosnan, Anthony A. Armstrong, Eva Emmell, Tam Susan H, Dennis R. Goulet, Mark L. Chiu
Publikováno v:
Biophysical Journal. 110(3)
Validation of bispecific antibodies (BsAb), which greatly enhance the engagement of therapeutic targets, can require development of in vivo studies that often require mouse surrogate Abs. However, preparation of highly pure BsAb samples involves mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386f295f8b8a7b9249fb6e5c42847381
Autor:
Patricia Rafferty, Peter J. Bugelski, Ram Achuthanandam, Renold J. Capocasale, Dorie Makropoulos, J. Quinn, Joanne O’Brien, Eva Emmell, Nicole Stowell
Publikováno v:
Cytometry Part A. :148-159
TNF-alpha is a pleitropic cytokine that expresses both pro- and anti-inflammatory activity and transgenic mice expressing human tumor necrosis factor-alpha (TNF-alpha) exhibit a progressive polyarthritis that models rheumatoid arthritis (RA). One of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dc23ced2f6b3b2d8230a8b0015e4e5
https://doi.org/10.1002/cyto.a.20512
https://doi.org/10.1002/cyto.a.20512
Autor:
J. Radewonuk, Jian Li, Don E. Griswold, Xiaozhou Shang, Eva Emmell, X.Y. Song, K.Y. Ma, Li Li
Publikováno v:
Cellular Immunology. 241:66-74
IgE plays a critical role in the pathogenesis of allergy and asthma. Therefore, suppression of IgE production would provide therapeutic benefits to patients suffering from these diseases. We have reported that the production of IgE is regulated diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3219c6262ab29cb543daeb7b587ee640
https://doi.org/10.1016/j.cellimm.2006.07.011
https://doi.org/10.1016/j.cellimm.2006.07.011
Autor:
Jian Li, Li Li, Eva Emmell, Michelle Bracht, Don E. Griswold, Xiaozhou Shang, Jennifer Radewonuk
Publikováno v:
Cellular Immunology. 241:75-84
CD4+CD25+ regulatory T cells (Tr) are important in maintaining immune tolerance to self-antigen (Ag) and preventing autoimmunity. Reduced number and inadequate function of Tr are observed in chronic autoimmune diseases. Adoptively transferred Tr effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0b9520e1f8b0fe076fa6f86ad9ed93
https://doi.org/10.1016/j.cellimm.2006.08.003
https://doi.org/10.1016/j.cellimm.2006.08.003