Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report

Autor: Jakob Benedict Seidelin, Inge Marie Svane, Eva Ellebaek, Henrik Vedel Nielsen, Emilie Kristine Dahl, Morten Helms, Rikke Boedker Holmstroem, Jacob Tveiten Bjerrum, Janne Bayer Andersen

Publikováno v: BMJ Open Gastroenterology, Vol 9, Iss 1 (2022)

Background Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.Cas

Externí odkaz: https://doaj.org/article/f345ce0c283a450c958e3063c09d7ea7

Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma

Autor: Maartje W. Rohaan, Troels H. Borch, Joost H. van den Berg, Özcan Met, Rob Kessels, Marnix H. Geukes Foppen, Joachim Stoltenborg Granhøj, Bastiaan Nuijen, Cynthia Nijenhuis, Inge Jedema, Maaike van Zon, Saskia Scheij, Jos H. Beijnen, Marten Hansen, Carlijn Voermans, Inge M. Noringriis, Tine J. Monberg, Rikke B. Holmstroem, Lidwina D.V. Wever, Marloes van Dijk, Lindsay G. Grijpink-Ongering, Ludy H.M. Valkenet, Alejandro Torres Acosta, Matthias Karger, Jessica S.W. Borgers, Renske M.T. ten Ham, Valesca P. Retèl, Wim H. van Harten, Ferry Lalezari, Harm van Tinteren, Astrid A.M. van der Veldt, Geke A.P. Hospers, Marion A.M. Stevense-den Boer, Karijn P.M. Suijkerbuijk, Maureen J.B. Aarts, Djura Piersma, Alfons J.M. van den Eertwegh, Jan-Willem B. de Groot, Gerard Vreugdenhil, Ellen Kapiteijn, Marye J. Boers-Sonderen, W. Edward Fiets, Franchette W.P.J. van den Berkmortel, Eva Ellebaek, Lisbet R. Hölmich, Alexander C.J. van Akkooi, Winan J. van Houdt, Michel W.J.M. Wouters, Johannes V. van Thienen, Christian U. Blank, Aafke Meerveld-Eggink, Sebastian Klobuch, Sofie Wilgenhof, Ton N. Schumacher, Marco Donia, Inge Marie Svane, John B.A.G. Haanen

Publikováno v: New England Journal of Medicine, 387(23), 2113-2125. MASSACHUSETTS MEDICAL SOC
The New England Journal of Medicine, 387, 2113-2125
New England journal of medicine, 387(23), 2113-2125. Massachussetts Medical Society
Rohaan, M W, Borch, T H, Van Den Berg, J H, Met, Ö, Kessels, R, Geukes Foppen, M H, Stoltenborg Granhøj, J, Nuijen, B, Nijenhuis, C, Jedema, I, Van Zon, M, Scheij, S, Beijnen, J H, Hansen, M, Voermans, C, Noringriis, I M, Monberg, T J, Holmstroem, R B, Wever, L D V, Van Dijk, M, Grijpink-Ongering, L G, Valkenet, L H M, Torres Acosta, A, Karger, M, Borgers, J S W, Ten Ham, R M T, Retèl, V P, Van Harten, W H, Lalezari, F, Van Tinteren, H, Van Der Veldt, A A M, Hospers, G A P, Stevense-Den Boer, M A M, Suijkerbuijk, K P M, Aarts, M J B, Piersma, D, Van Den Eertwegh, A J M, De Groot, J W B, Vreugdenhil, G, Kapiteijn, E, Boers-Sonderen, M J, Fiets, W E, Van Den Berkmortel, F W P J, Ellebaek, E, Hölmich, L R, Van Akkooi, A C J, Van Houdt, W J, Wouters, M W J M, Van Thienen, J V, Blank, C U, Meerveld-Eggink, A, Klobuch, S, Wilgenhof, S, Schumacher, T N, Donia, M, Svane, I M & Haanen, J B A G 2022, ' Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma. ', New England Journal of Medicine, vol. 387, no. 23, pp. 2113-2125 . https://doi.org/10.1056/NEJMoa2210233
The New England journal of medicine, 387(23), 2113-2125. Massachussetts Medical Society
New England Journal of Medicine, 387(23), 2113-2125. MASSACHUSETTS MEDICAL SOCIETY
The New England Journal of Medicine, 387, 23, pp. 2113-2125

Item does not contain fulltext BACKGROUND: Immune checkpoint inhibitors and targeted therapies have dramatically improved outcomes in patients with advanced melanoma, but approximately half these patients will not have a durable benefit. Phase 1-2 tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf28a71e5a16116e2b0f59cdac9485a
https://research.rug.nl/en/publications/9033fdbd-9e6f-4cca-a35b-50890da9f292

Data from Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen

Autor: Inge Marie Svane, Per thor Straten, Mads Hald Andersen, Özcan Met, Helle Westergren Hendel, Lisbet Rosenkrantz Hölmich, Trine Zeeberg Iversen, Per Kongsted, Troels Holz Borch, Eva Ellebaek, Marco Donia, Rikke Andersen

Purpose: Adoptive cell transfer therapy (ACT) based on autologous tumor-infiltrating lymphocytes (TIL) has achieved impressive clinical results in several phase I and II trials performed outside of Europe. Although transient, the toxicities associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6791d9b1d841a9cd23a4b169c70ed21
https://doi.org/10.1158/1078-0432.c.6523761.v1

Data from Long-lasting Disease Stabilization in the Absence of Toxicity in Metastatic Lung Cancer Patients Vaccinated with an Epitope Derived from Indoleamine 2,3 Dioxygenase

Autor: Inge Marie Svane, Mads Hald Andersen, Anders Mellemgaard, Per thor Straten, Bente Holm, Birthe Moerk Thomsen, Cécile Gouttefangeas, Claus Zeyher, Jon Bjoern, Stine Kiaer Larsen, Rikke Andersen, Eva Ellebaek, Lotte Engell-Noerregaard, Trine Zeeberg Iversen

Purpose: To investigate targeting of indoleamine 2,3 dioxygenase (IDO) enzyme using a synthetic peptide vaccine administered to patients with metastatic non–small cell lung cancer (NSCLC).Experimental Design: In a clinical phase I study, we treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f164954f0123c75c288ad63452afb38
https://doi.org/10.1158/1078-0432.c.6521843

Supplementary Methods from Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling

Autor: Inge Marie Svane, Göran Jönsson, Barbara Seliger, Ton N. Schumacher, Jonas A. Nilsson, Per thor Straten, Mads Hald Andersen, Henrik Schmidt, Sine Reker Hadrup, Martin Lauss, Massimo Libra, Ferdinando Nicoletti, Paolo Fagone, Anja Mueller, Eva Ellebæk, Shamaila Munir Ahmad, Manja Idorn, Rikke Andersen, Mattias F. Lindberg, Pia Kvistborg, Marit van Buuren, Katja Harbst, Marco Donia

This file contains supplementary information on the methods used to generate information on the immunology and tumor biology of the patient case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f43b6843c18b97fa219ba6316a0f0c8
https://doi.org/10.1158/0008-5472.22414446