Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Eva, Altmann"'
Autor:
Cristina Martínez, Elisa Iniesto, Marta García-León, Daniel García-Corredera, Sandra Fonseca, César Santiago, Mei Yang, Renbo Yu, Haodong Chen, Eva Altmann, Martin Renatus, Xing Wang Deng, Vicente Rubio
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114802- (2024)
Summary: Phytohormone abscisic acid (ABA) regulates key plant development and environmental stress responses. The ubiquitin-proteasome system tightly controls ABA signaling. CULLIN4-RING (CRL4) E3 ubiquitin ligases use the substrate receptor module C
Externí odkaz:
https://doaj.org/article/79c91f61f5e741bc9e33adf0480acebe
Autor:
Matthew Jones, Philipp Grosche, Andreas Floersheimer, Jérome André, Raphael Gattlen, Dieter Oser, Juliette Tinchant, Roman Wille, Barbara Chie-Leon, Marc Gerspacher, Peter Ertl, Nils Ostermann, Eva Altmann, Eusebio Manchado, Thomas Vorherr, Patrick Chène
Publikováno v:
Biochemistry. 62:1321-1329
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f67791accb97a6decbf5925a2187b36
https://doi.org/10.1021/acs.biochem.2c00690
https://doi.org/10.1021/acs.biochem.2c00690
Boronic acids are essential building blocks used for the synthesis of bioactive molecules, the generation of chemical libraries and the exploration of structure-activity relationships. As a result, more than ten thousand boronic acids are commerciall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918557a44b0283090ac5fd0b00e7927f
https://doi.org/10.26434/chemrxiv-2023-gr155
https://doi.org/10.26434/chemrxiv-2023-gr155
Autor:
Anita Schlierf, Eva Altmann, Jean Quancard, Anne B. Jefferson, René Assenberg, Martin Renatus, Matthew Jones, Ulrich Hassiepen, Michael Schaefer, Michael Kiffe, Andreas Weiss, Christian Wiesmann, Richard Sedrani, Jörg Eder, Bruno Martoglio
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Dysregulation of protein degradation by the ubiquitin-proteasome system is a feature commonly associated with cancer. Here, the authors develop an orally available small molecule that inhibits CSN5, the proteolytic subunit of the COP9 signalosome, an
Externí odkaz:
https://doaj.org/article/6813730e8c8647398b624ca609051b9b
Publikováno v:
European journal of medicinal chemistry. 238
Analysis of structure-activity data from a large corpus of medicinal chemistry literature identified a set of ring replacements that have a significant chance of improved biological activity. A database of these replacements for 245 common heterocycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556905189cd013ffb5bf8ae3c7f1623e
https://pubmed.ncbi.nlm.nih.gov/35635950
https://pubmed.ncbi.nlm.nih.gov/35635950
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9969a4c36550186a210fdfae8c1af415
https://doi.org/10.1021/acs.jmedchem.0c01245
https://doi.org/10.1021/acs.jmedchem.0c01245
Publikováno v:
Bioorganic & Medicinal Chemistry. 81:117194
Structures of the large majority of bioactive molecules are composed of several rings that are decorated by substituents and connected by linkers. While numerous cheminformatics studies focusing on rings and substituents are available, practically no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e308ff9e953368cb2b1a88a09216f4c
https://doi.org/10.1016/j.bmc.2023.117194
https://doi.org/10.1016/j.bmc.2023.117194
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c9148f487b1a8d48b0cb731fa2d9337
https://pubmed.ncbi.nlm.nih.gov/33252239
https://pubmed.ncbi.nlm.nih.gov/33252239
Publikováno v:
Journal of medicinal chemistry. 63(15)
The concept of functional groups (FGs), sets of connected atoms that can determine the intrinsic reactivity of the parent molecule and in part are responsible for the overall properties of the molecule, form a foundation within modern medicinal chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34e2173bdac1057839a44378b541cde
https://pubmed.ncbi.nlm.nih.gov/32663408
https://pubmed.ncbi.nlm.nih.gov/32663408
Autor:
Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein
Publikováno v:
Journal of medicinal chemistry. 63(15)
The serine protease Factor XI (FXI) is a prominent drug target as it holds promise to deliver efficacious anti-coagulation without an enhanced risk of major bleeds. Several efforts have been described targeting the active form of the enzyme, FXIa. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ad110af1ecb6144e75a9298044b57
https://pubmed.ncbi.nlm.nih.gov/32551603
https://pubmed.ncbi.nlm.nih.gov/32551603