EFICÁCIA E TOXICIDADE DE TENOFOVIR (TDF) E ENTRICITABINA (FTC) PARA INFECÇÕES LEVE A MODERADA PELO SARS-COV-2

Autor: Erico Antonio Gomes de Arruda, Roberto da Justa Pires Neto, Melissa Soares Medeiros, Alexandre Havt, Aldo Angelo Moreira Lima, Eurico de Arruda Neto, Daniel Sampaio Rodrigues, Kaique Abraão Luz Alves, Norberto Peporine Lopes, José Quirino da Silva Filho, Pedro Jorge Caldas Magalhães, Fabiana Maria da Silva Nascimento, Armênio Aguiar dos Santos, Ana Karolina dos Santos, Terezinha Freire França, Luciana França da Silva, Kátia Maria Lima Nogueira, Herlice Veras Do Nascimento, Francisco de Sousa Junior, Charles Roberto Sousa de Melo, Charliene Sousa de Melo, José Amadeus Sousa, Maria Jacinilda Rodrigues Pereira, João Victor Cosmo Machado, Renan Lobo Cavalcanti, Marenilda Justa da Silva, Francisca Mônica da Silva Nascimento, Dayane Feitosa Guedes de Melo, Lucia de Fátima Alves, Maria Luzia Sousa de Melo, Rosania Maria de Paula Silva, Liana Perdigão Melo Viana, Denise Girão Limaverde Lima, Lyvia Maria Vasconcelos Carneiro Magalhães

Publikováno v: Brazilian Journal of Infectious Diseases, Vol 26, Iss , Pp 102026- (2022)

Introdução: Vários fármacos têm sido avaliados para o tratamento da COVID-19, mas somente o antiviral remdesivir foi registrado nos órgãos regulatórios dos principais países desenvolvidos para esse fim. TDF e FTC demonstraram atividade contr

Externí odkaz: https://doaj.org/article/790821b242144b75885b69f7399f5e1c

Acute Chikungunya Infection Induces Vascular Dysfunction by Directly Disrupting Redox Signaling in Endothelial Cells

Autor: José Teles de Oliveira-Neto, Juliano de P. Souza, Daniel Rodrigues, Mirele R. Machado, Juliano V. Alves, Paula R. Barros, Alecsander F. Bressan, Josiane F. Silva, Tiago J. Costa, Rafael M. Costa, Daniella Bonaventura, Eurico de Arruda-Neto, Rita C. Tostes, Emiliana P. Abrão

Publikováno v: Cells, Vol 13, Iss 21, p 1770 (2024)

Chikungunya virus (CHIKV) infection is characterized by febrile illness, severe joint pain, myalgia, and cardiovascular complications. Given that CHIKV stimulates reactive oxygen species (ROS) and pro- and anti-inflammatory cytokines, events that dis

Externí odkaz: https://doaj.org/article/62f4c2cda7ac4704b065d4d037d0cbed

Drug repurposing to face Covid-19: Celastrol, a potential leading drug capable of inhibiting SARS-CoV-2 replication and induced inflammation

Autor: Martin K. Amstalden, Suzelei C. França, Eurico de Arruda Neto, Ronaldo B. Martins, Carlos Alessandro Fuzo, Thais Martins de Lima, Juliano de Paula Souza, Thais Fernanda de Campos Fraga-Silva, Lúcia Helena Faccioli, Thais Canassa-DeLeo, Marcelo Dias-Baruffi, Vânia Luiza Deperon Bonato

The global emergence of Covid-19 has caused huge human casualties. Clinical manifestations of the disease vary from asymptomatic to lethal, and the symptomatic form can be associated with cytokine storm and non-homeostatic inflammatory response. In f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eebd937f1dbd38fc4381652cfa42d5e
https://doi.org/10.1101/2021.04.20.439992

SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

Autor: Bruna Manuella Souza Silva, Jaqueline Aline Gerhardt, Iêda Maria Pereira de Sousa, Aline Gazzola Fragnani Valenca, Alessandro S. Farias, M. C. Martini, Maria Ercilia de Paula Castilho Stefano, Vanessa Bettini, Eurico de Arruda Neto, Marjorie Cornejo Pontelli, Paulo Louzada-Junior, Amaro Nunes Duarte-Neto, Guilherme Podolski-Gondim, Bradley J. Smith, Clarissa L. Yasuda, Marina K. M. Alvim, Solange Maria Gonçalves, Marcelo A. Mori, Thais Mauad, Raissa G. Ludwig, Mateus Henrique Nogueira, Elessandra Dias da Rocha, Natália Brunetti Silva, Isadora Marques Paiva, Daniel A. Toledo-Teixeira, André Schwambach Vieira, Ana Campos Codo, Patrícia Brito Rodrigues, Lucas Alves Tavares, José Roberto da Silva Junior, Adriano Sebollela, Fernando Q. Cunha, Niele D. Mendes, Guilherme Ludwig, Gustavo Gastão Davanzo, Stevens K. Rehen, André Saraiva Leão Marcelo Antunes, Glaucia M. Almeida, Verônica M. Saia-Cereda, Daniel Martins-de-Souza, Julia Forato, Lucas Scardua Silva, Egidi Mayara Silva Firmino, Stéfanie Primon Muraro, Bruno Marcel Silva de Melo, Rosa Maria Mendes Viana, Ronaldo B. Martins, Marco Aurélio Ramirez Vinolo, Pedro M. Moraes-Vieira, Ícaro Maia Santos de Castro, Carolina Brandao-Teles, Helder I. Nakaya, Guilherme Reis-de-Oliveira, Lívia Liviane Damião, ítalo Karmann Aventurato, Li Siyuan, Fernando Cendes, Marcelo Volpon Santos, Pierina Lorencini Parise, Carolina Demarchi Munhoz, Pedro Henrique Vendramini, Mariana Rabelo de Brito, Sabrina Setembre Batah, José C. Alves-Filho, Fernanda Crunfli, Gabriel Palermo Ruiz, Victor Corasolla Carregari, Giuliana S. Zuccoli, Flávio P. Veras, Paulo Hilário Nascimento Saldiva, Licia C. Silva-Costa, Maira N. Benatti, Luiz Henrique Lopes da Silva, Gabriela Fabiano de Souza, Rafaela M. Guimarães, Brunno Machado de Campos, Rafael Batista João, Thiago M. Cunha, Luiz Fernando Ferraz da Silva, Thiago L. Knittel, Luciano Neder, José Luiz Proença Modena, André Damasio, Marisa Dolhnikoff, Renê Donizeti Ribeiro de Oliveira, Alexandre Todorovic Fabro, Mariene R. Amorim

COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms and are associated with altered cerebr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::735d528fb70ac15463da1a095d30ab2c
https://doi.org/10.21203/rs.3.rs-104944/v1

IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection

Autor: M. C. Prates, Davi Casale Aragon, Carolina Augusta Arantes Portugal, Ana Paula de Carvalho Panzeri Carlotti, Fernando Q. Cunha, Eurico de Arruda Neto, Italo A. Castro, Ronaldo B. Martins, Bruna Lais Santos de Jesus, Ricardo de Souza Cardoso, José Carlos Farias Alves Filho, Talita Bianca Gagliardi, Marcus Vinicius Gomes da Silva

Publikováno v: Cytokine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Highlights • An exacerbated activation of IL-33/ST2 axis was associated with severity of viral ALRI. • Detectable NPA IL-33 and sST-2 levels were risk factors for mechanical ventilation. • An increment in NPA sST2 levels was associated with lon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386dc6b78227a0c2377d0dc6166ad982
https://doi.org/10.1016/j.cyto.2019.154965