Applications of single-cell RNA sequencing in drug discovery and development

Autor: Bram Van de Sande, Joon Sang Lee, Euphemia Mutasa-Gottgens, Bart Naughton, Wendi Bacon, Jonathan Manning, Yong Wang, Jack Pollard, Melissa Mendez, Jon Hill, Namit Kumar, Xiaohong Cao, Xiao Chen, Mugdha Khaladkar, Ji Wen, Andrew Leach, Edgardo Ferran

Publikováno v: Nature Reviews Drug Discovery.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31cd66fe3809ffa66fed677963c2e917
https://doi.org/10.1038/s41573-023-00688-4

Metagenomics approach for Polymyxa betae genome assembly enables comparative analysis towards deciphering the intracellular parasitic lifestyle of the plasmodiophorids

Autor: Alain Decroës, Gipsi Lima-Mendez, Lorna Richardson, Jun-Min Li, Robert D. Finn, Anne Legrève, Euphemia Mutasa-Gottgens, Mathieu Mahillon, Claude Bragard

Publikováno v: Genomics, Vol. 114, no.1, p. 9-22 (2022)
Decroës, A, Li, J M, Richardson, L, Mutasa-Gottgens, E, Lima-Mendez, G, Mahillon, M, Bragard, C, Finn, R D & Legrève, A 2022, ' Metagenomics approach for Polymyxa betae genome assembly enables comparative analysis towards deciphering the intracellular parasitic lifestyle of the plasmodiophorids ', Genomics, vol. 114, no. 1, pp. 9-22 . https://doi.org/10.1016/j.ygeno.2021.11.018

Genomic knowledge of the tree of life is biased to specific groups of organisms. For example, only six full genomes are currently available in the rhizaria clade. Here, we have applied metagenomic techniques enabling the assembly of the genome of Pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8cba06c07da8529803c0c54bc8e8af
https://pubmed.ncbi.nlm.nih.gov/34798282

Development of a recombinant antibody ELISA test for the detection of Polymyxa betae and its use in resistance screening

Autor: Euphemia Mutasa-Gottgens, M. C. Luterbacher, D.M. Chwarszczynska, C. S. Kingsnorth, M. J. C. Asher, Gary Keane

Publikováno v: Plant Pathology. 52:673-680

An ELISA test was developed for the quantitative detection of the obligate parasite Polymyxa betae, the vector of Beet necrotic yellow vein virus (BNYVV), in infected sugarbeet roots. The test used monoclonal and polyclonal antibodies raised to a rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b49aae564533a2f05bc67408446ae695
https://doi.org/10.1111/j.1365-3059.2003.00928.x

Development of new quantitative physiological and molecular breeding parameters based on the sugar-beet vernalization intensity model

Autor: Peter Hedden, Helen F. Holmes, Tansy Y. P. Chia, Euphemia Mutasa-Gottgens, Tinashe Chiurugwi, Aiming Qi

SUMMARYSugar-beet crops, Beta vulgaris spp. vulgaris (L), suffer from premature bolting and flowering as a consequence of prolonged exposure to cold conditions (vernalization). This reduces crop yield and quality and could be avoided if bolting-resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb05b85772c26adf1113f5cfd712407

Bolting and flowering control in sugar beet: relationships and effects of gibberellin, the bolting gene B and vernalization

Autor: Andrea Jennings, Aiming Qi, Uwe Hohmann, Wenying Zhang, Euphemia Mutasa-Gottgens, Peter Hedden, Andreas E. Müller, Gretel Schulze-Buxloh

Publikováno v: AoB Plants

Using a co-dominant genotypic PCR marker we show for the first time that, in sugar beet, the GA and B-gene pathways are independent for bolt initiation. We show that vernalization permits GA-dependant stem elongation and that the B-allele influences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6915da6163cc43512ea4277096da13
http://europepmc.org/articles/PMC3000703